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3D printing doxofylline orally disintegrating tablets and preparation method thereof

A doxofylline, 3D printing technology, applied in the direction of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of long disintegration time, inability to meet emergency patients, etc. Low toxicity and side effects of drugs, personalized printing, and great curative effect

Active Publication Date: 2018-02-09
江苏互竑生物医学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the existing doxofylline ordinary tablets on the market take a long time to disintegrate, which cannot meet the needs of emergency patients; in addition, atomized inhalation of doxofylline solution can quickly take effect, but it needs to use atomization equipment and cannot be used at any time. Meet patient needs anywhere

Method used

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  • 3D printing doxofylline orally disintegrating tablets and preparation method thereof
  • 3D printing doxofylline orally disintegrating tablets and preparation method thereof
  • 3D printing doxofylline orally disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The prescription is as follows:

[0029]

[0030] 3D printing parameters are as follows:

[0031]

[0032]

[0033] The preparation method is as follows:

[0034] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer.

[0035] (2) Calculated by weight percentage, mix doxofylline (50%), sucrose (39%), povidone K30 (10%), and micronized silica gel (1%) evenly in proportion, and load it into 3D printing as a medicine powder In the powder box of the rapid prototyping machine.

[0036] (3) Put 1% povidone K30-50% ethanol solution into the ink cartridge.

[0037] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print doxofylline orally disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.3mm on the powder bed, and then prints the no...

Embodiment 2

[0042] The prescription is as follows:

[0043]

[0044] 3D printing parameters are as follows:

[0045]

[0046]

[0047] The preparation method is as follows:

[0048] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer.

[0049] (2) Calculated by weight percentage, doxofylline (52%), sucrose (30%), low-substituted hydroxypropyl methylcellulose (5%), povidone K30 (10%), micropowder silica gel ( 1%) and sucralose (2%) are uniformly mixed in proportion, and packed into the powder box of the 3D printing rapid prototyping machine as a medicinal powder.

[0050] (3) Put 50% ethanol solution into the cartridge.

[0051] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print doxofylline orally disintegrating tablets: the powder spreading device first spreads a layer of powder with a thick...

Embodiment 3

[0056] The prescription is as follows:

[0057]

[0058] 3D printing parameters are as follows:

[0059]

[0060] The preparation method is as follows:

[0061] (1) According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system of the 3D printer.

[0062] (2) Calculated by weight percentage, doxofylline (57%), sucrose (20%), croscarmellose sodium starch (10%), povidone K30 (10%), micronized silica gel (1%) ), stevioside (2%) are mixed evenly in proportion, and packed in the powder box of 3D printing rapid prototyping machine as medicine powder.

[0063] (3) Put 1% povidone K30-50% ethanol solution into the ink cartridge.

[0064] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print doxofylline orally disintegrating tablets: the powder spreading device first spreads a layer of powder with a thickness of 0.2mm on the p...

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Abstract

The invention discloses 3D printing doxofylline orally disintegrating tablets which are mainly prepared from, by mass, 40-60% of doxofylline, 20-40% of filling agent, 0-10% of disintegrating agent, 2-10% of binder, 0.1-1.0% of micropowder silica gel and 0-2% of corrigent by adopting 3D printing technology. The invention further discloses a preparation method of the doxofylline orally disintegrating tablets. The doxofylline orally disintegrating tablets are high in drug release speed, can improve drug taking compliance of patients and is especially convenient for old people, children and peoplehaving trouble in swallowing to take.

Description

technical field [0001] The invention relates to a doxofylline orally disintegrating tablet, in particular to a 3D printed doxofylline orally disintegrating tablet. The invention also relates to a preparation method of the doxofylline orally disintegrating tablet. Background technique [0002] Three-dimensional printing technology (three dimension printing, 3DP) is a rapid prototyping technology based on digital models. The core idea of ​​3D printing first originated in the United States at the end of the 19th century, and it was not until the late 1980s that it was developed by the Massachusetts Institute of Technology. 3D printing technology is to design and construct a three-dimensional model on computer software based on the CAD model or CT data of the object. It can quickly and accurately manufacture objects with special shapes or complex internal structures. [0003] 3D printing technology was initially used in the fields of manufacturing, aerospace and industrial de...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/32A61K47/38A61K47/36A61K31/522A61P11/06
CPCA61K9/0056A61K9/2027A61K9/2054A61K9/2059A61K9/2095A61K31/522
Inventor 郑易
Owner 江苏互竑生物医学有限公司
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