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Medicine composition for improving safety of compound humifuse euphorbia herb injection solution

The technology of Dijin grass and its composition is applied in the field of medicine, which can solve the problems of accelerating the pH value of the liquid medicine, the drop of the pH value of the solution, and the easy rancidity of glycerin, and achieves the advantages of improving safety, low dosage, and obvious dissolution-assisting effect Effect

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and glycerol is easy to become rancid, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Medicine composition for improving safety of compound humifuse euphorbia herb injection solution
  • Medicine composition for improving safety of compound humifuse euphorbia herb injection solution
  • Medicine composition for improving safety of compound humifuse euphorbia herb injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016] Preparation method: decoct Dijincao and Bailiangjin with water twice, 2 hours each time, combine the decoction, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make The ethanol content is 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is decompressed Concentrate to a relative density of about 1.15 (80°C), and prepare the liquid medicine for later use; decoct chicken bone grass twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C) , let it cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20 (80°C), add ethanol to make the ...

Embodiment 2

[0018]

[0019] Preparation method: decoct Dijincao and Bailiangjin with water twice, 2 hours each time, combine the decoction, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make The ethanol content is 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is decompressed Concentrate to a relative density of about 1.15 (80°C), and prepare the liquid medicine for later use; decoct chicken bone grass twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C) , let it cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20 (80°C), add ethanol to make the ...

Embodiment 3

[0021]

[0022] Preparation method: decoct Dijincao and Bailiangjin with water twice, 2 hours each time, combine the decoction, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make The ethanol content is 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is decompressed Concentrate to a relative density of about 1.15 (80°C), and prepare the liquid medicine for later use; decoct chicken bone grass twice, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (80°C) , let it cool, add ethanol to make the ethanol content 65%, let it stand overnight, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20 (80°C), add ethanol to make the ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for improving the safety of compound dijincao injection. The pharmaceutical composition is a pharmaceutical composition for injection mainly made of Dijincao extract, Bailiangjin extract, Jigucao extract and hydroxypropyl acrylate. In the present invention, the co-solvent with better safety and more obvious solubilizing effect is used to replace the co-solvent glycerin in the compound Dijincao injection, which has potential safety hazards and affects product quality, and the safety of hydroxypropyl acrylate is higher than that of glycerol Moreover, the dosage is lower, which reduces the probability and risk of adverse drug reactions and improves the safety of clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition for improving the safety of compound dijincao injection. Background technique [0002] The standard of compound Dijincao injection is recorded in the drug standard issued by the Ministry of Health (Chinese medicine prescription preparation). The raw materials are Dijincao, Bailiangjin and Jigucao, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Dijincao Injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/14A61K47/26A61K36/48A61P15/00A61P29/00
CPCA61K9/08A61K36/185A61K36/47A61K36/48A61K47/14A61K47/26A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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