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Medicine composition for improving safety of compound rhizoma corydalis decumbentis injection solution

A technology of composition and injection, which is applied in the field of medicine, achieves good safety, reduces the chance and risk of adverse reactions, and has high safety effects

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium benzoate is also added to the domestically produced compound summer-free injection as a co-solvent, facing the same problem

Method used

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  • Medicine composition for improving safety of compound rhizoma corydalis decumbentis injection solution
  • Medicine composition for improving safety of compound rhizoma corydalis decumbentis injection solution
  • Medicine composition for improving safety of compound rhizoma corydalis decumbentis injection solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016] Preparation method: add water to decoct snow lotus and snow lotus twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Yinlan is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative densi...

Embodiment 2

[0018]

[0019] Preparation method: add water to decoct snow lotus and snow lotus twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Yinlan is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative densi...

Embodiment 3

[0021]

[0022] Preparation method: add water to decoct snow lotus and snow lotus twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the liquid medicine is ready for use; Yinlan is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative densi...

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Abstract

The invention discloses a medicine composition for improving the safety of a compound rhizoma corydalis decumbentis injection solution. The medicine composition is mainly prepared from a rhizoma corydalis decumbentis extract, a flos saussureae involucratae extract, a herba cephalantherae erectae extract and an enteric coated acrylic resin. According to the medicine composition provided by the invention, a cosolvent with better safety and a more obvious dissolution-promotion effect is adopted to replace a cosolvent sodium benzoate with potential safety hazard and probability of affecting product quality in the compound rhizoma corydalis decumbentis injection solution, the safety of the enteric coated acrylic resin is higher than the safety of the sodium benzoate, the dosage of the enteric coated acrylic resin is lower than the dosage of the sodium benzoate, the probability and the risk of side effects happened by the medicine are reduced, and the safety of clinical medication is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for improving the safety of compound summer injection. Background technique [0002] The standard of the compound summer-free injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine), and the raw materials are summer-free, snow lotus, and Yinlan, which belong to the traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound Xiawu injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K47/32A61K36/898A61P15/00A61P29/00A61P19/04
CPCA61K9/08A61K9/0019A61K9/19A61K36/285A61K36/66A61K36/898A61K47/32
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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