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Method for preparing imitative mussel functionalized fracture adhesive

An adhesive and functionalization technology, which is applied in the preparation of fracture adhesives and mussel-like functional fracture adhesives, can solve problems such as poor viscosity, and achieve reduced rigidity, good adhesiveness, and high Biosecurity Effects

Active Publication Date: 2018-01-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the defects and deficiencies in the prior art, the present invention provides a method for preparing a mussel-like functional fracture adhesive, which overcomes the defect that the bone adhesive in the prior art has poor viscosity in a humid environment

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0027] The preparation method of the imitation mussel functionalized fracture adhesive of the present invention uses catechol-containing structural polymer, hydroxyapatite and chitosan as raw materials, wherein hydroxyapatite is a surface active material, which It has similar chemical composition and structure to biological hard tissue, has good biological activity and compatibility, has no stimulation and repulsion to the tissue after being implanted in the human body, and can form a strong chemical combination with bone, and is used as a bone defect repair tool. The filling material provides a scaffold for the formation of new bone and plays the role of bone conduction. It is an ideal hard tissue replacement material; chitosan can be absorbed by the human body and is suitable as a carrier for slow-release and controlled-release preparations. Make the hydroxyapatite particles easy to shape while reducing the material rigidity.

[0028] And the raw materials for preparing poly...

Embodiment 1

[0037] In this embodiment, direct condensation reaction is used to obtain polyethylene glycol acrylate solids by combining 15 g of polyethylene glycol and 45 g of acrylic acid chloride under the conditions of polymerization inhibitor hydroquinone and catalyst p-toluenesulfonic acid. Then the above solid was dissolved with ethanol, reacted with 90 g of dopamine hydrochloride to generate polymer containing catechol structure, ie white polyethylene glycol acrylate dopamine solid.

[0038] Weigh 20g chitosan, add 100mL mass fraction of 5% acetic acid solution, heat up to 60°C, stir evenly to form an acetic acid solution of chitosan; then weigh 5g hydroxyapatite and add it to the acetic acid solution of chitosan in the step , under the condition of maintaining 60° C., stirring for 15 minutes to dissolve all the hydroxyapatite in the acetic acid solution of chitosan to obtain a mixed solution, which was centrifuged to remove air bubbles for later use.

[0039] In parts by weight, we...

Embodiment 2

[0041] In this embodiment, direct condensation reaction was used to obtain polyethylene glycol acrylate solids by combining 17.5 g of polyethylene glycol and 52.5 g of acrylic acid chloride under the conditions of polymerization inhibitor hydroquinone and catalyst p-toluenesulfonic acid. Then above-mentioned solid is dissolved with ethanol, reacts with 95g dopamine hydrochloride to generate polymer containing catechol structure, namely white polyethylene glycol acrylate dopamine solid.

[0042] Weigh 30g of chitosan, add 150mL mass fraction of 5% acetic acid solution, heat up to 65°C, stir to form an acetic acid solution of chitosan; then weigh 7.5g of hydroxyapatite and add it to the acetic acid solution of chitosan in the step In the process, under the condition of maintaining 65°C, stir for 20 minutes to dissolve all the hydroxyapatite in the acetic acid solution of chitosan to obtain a mixed solution, which is centrifuged to remove air bubbles for later use.

[0043]In par...

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Abstract

The invention discloses a method for preparing an imitative mussel functionalized fracture adhesive. The method adopts a catechol-containing structural polymer, hydroxyapatite and chitosan as raw materials, the catechol-containing structural polymer is prepared from polyethylene glycol, chloroacrylic acid and a catechol-containing structural compound, and the catechol-containing structural compound is dopamine hydrochloride. The method comprises the following steps: carrying out a condensation reaction on the polyethylene glycol and the chloroacrylic acid; dissolving the obtained condensationproduct, and reacting the condensation product with the dopamine hydrochloride to generate the catechol-containing structural polymer; weighing the chitosan, and adding the chitosan into an acetic acid solution to form an acetic acid solution of chitosan; weighing the hydroxyapatite, and adding the hydroxyapatite into the acetic acid solution of chitosan to obtain a mixed solution; and weighing the catechol-containing structural polymer and the mixed solution, and stirring and mixing the catechol-containing structural polymer and the mixed solution to obtain the adhesive. The adhesive has extremely strong adhesive property, plays a full role in bone adhesion under the wet conditions in the physiological environment, and also has very good adhesive property, high bio-safety, and good bone defect filling performance.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and relates to a preparation method of a fracture adhesive, in particular to a preparation method of a mussel-like functional fracture adhesive. Background technique [0002] There are usually two methods of clinical treatment of fractures: external fixation and surgical treatment. External fixation is an indirect fixation. After a long period of fixation, it is easy to cause limb muscle atrophy, osteoporosis and other problems; while internal fixation is likely to cause osteoporosis or cause internal Fixation is loose, and once infection occurs, metal foreign objects will seriously hinder the healing of wounds and fractures, especially for comminuted fractures, it is more difficult to fix, and poor results will cause a series of sequelae. With the advancement of medicine, the clinical requirements for the effect of surgical techniques and auxiliary materials are getting higher and h...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/04A61L24/02A61L24/00A61L27/58A61L27/50A61L27/20A61L27/18A61L27/12
Inventor 雷伟冯亚非相庚胡晓帆陆奕兆王林
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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