Black nightshade extract, and separation and extraction method and application thereof in anti-inflammatory and analgesic drug

An extraction method and extract technology, applied in the field of natural products, can solve the problem of unclear active components and effective parts of Solanum nigrum, and achieve the effects of anti-inflammatory and analgesic effects, exact effects, and simple separation and extraction methods.

Inactive Publication Date: 2018-01-26
GUANGZHOU CITY POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of unclear active ingredients and effective parts of Solanum nigrum in the prior art, the primary purpose of the present invention is to provide a method for separating and extracting Solanum nigrum extract

Method used

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  • Black nightshade extract, and separation and extraction method and application thereof in anti-inflammatory and analgesic drug
  • Black nightshade extract, and separation and extraction method and application thereof in anti-inflammatory and analgesic drug
  • Black nightshade extract, and separation and extraction method and application thereof in anti-inflammatory and analgesic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of Solanum nigrum extract, is made by following steps:

[0024] Crush the whole plant of Solanum nigrum, pass through a 20-mesh sieve, add water to submerge the medicinal materials, heat to 100°C, extract at a constant temperature for 1 hour, extract twice, filter, combine the filtrates, concentrate into an extract (black), and become Solanum nigrum extract.

Embodiment 2

[0026] A kind of Solanum nigrum extract, is made by following steps:

[0027] The whole plant of Solanum nigrum is crushed, passed through a 40-mesh sieve, added water, ultrasonically extracted at room temperature for 30 minutes, extracted three times, filtered the water extract, combined the filtrate, and the filtrate was rotary evaporated to remove the solvent to obtain a brown-black extract, which is the Solanum nigrum extract.

Embodiment 3

[0029] A kind of Solanum nigrum extract, is made by following steps:

[0030] Crush the whole plant of Solanum nigrum without sieving, add water and heat to 60°C, decoct at constant temperature for one day, extract twice, filter, combine the filtrate, add chloroform to the filtrate for extraction, let stand, the filtrate is divided into two layers, remove the water layer, and take the chloroform layer . The chloroform was removed by rotary evaporation, and the dark green extract was obtained, which was the extract of Solanum nigrum.

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Abstract

The invention discloses a black nightshade extract, and a separation and extraction method and application of the black nightshade extract in preparation of an anti-inflammatory and analgesic drug. The separation and extraction method of the black nightshade extract comprises the following steps: smashing a black nightshade whole plant, adding water or ethanol solution, carrying out extraction a plurality of times, filtering extract, mixing filtrate, and concentrating into extract which is the black nightshade extract. An organic solvent can be added for extraction after the filtrate is mixed,then an organic solvent layer is taken and then is concentrated into extract. The black nightshade extract disclosed by the invention has the advantages that the separation and extraction method is simple, efficient and energy-saving, and the black nightshade extract has definite anti-inflammatory and analgesic effects and can be used for preparing drugs for related applications.

Description

technical field [0001] The invention belongs to the field of natural products, and in particular relates to a nightshade extract, a separation and extraction method thereof, and an application in the preparation of anti-inflammatory and analgesic drugs. Background technique [0002] Solanum nigrum (Solanum nigrum L.), is a one to perennial wild herbaceous plant, widely distributed all over the world, born in farmland, wasteland, field edge and near villages. Also known as bitter vegetable, bitter sunflower, old crow's eye, sky eggplant, black nightshade is bitter in taste, cold in nature, slightly sweet, and slightly poisonous. Return lung, kidney two warps. It has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, diuresis and swelling, relieving cough and eliminating phlegm. Indications for cold and fever, toothache, eczema, pruritus, high blood pressure, chronic bronchitis, acute nephritis, urinary tract infection, cance...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P29/00A61P31/04
Inventor 贾强王英江津津张越华胡玉枚曹艳丽刘念龙燕萍
Owner GUANGZHOU CITY POLYTECHNIC
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