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Girald acanthopanax bark extract, preparation method and application

A kind of Acanthopanax bark and extract technology, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of unfavorable industrial production cost, large amount of excipients, low content of active ingredients, etc., and achieve good anti-inflammatory effect pain, excellent effect

Inactive Publication Date: 2017-02-22
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the total glycosides of the Radix Radix Cortex is excellent in effect, the content of active ingredients in its extract is low. If it is prepared into a prescription, the amount of excipients will be large, which is not conducive to the saving of industrial production costs, and its dosage is relatively large. , inconvenient for patients to use

Method used

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  • Girald acanthopanax bark extract, preparation method and application
  • Girald acanthopanax bark extract, preparation method and application
  • Girald acanthopanax bark extract, preparation method and application

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Effect test

Embodiment 1

[0029] Embodiment 1 The preparation of the Radix Acanthopanax bark extract of the present invention

[0030] 1. Preparation method

[0031] Weigh 4 kg of Radix Acanthopanax Radix, soak in water overnight, add 15 times the amount of water to decoct 3 times (the decoction time is 30 minutes), combine the decoction, heat and evaporate to a small volume (concentrate to 5000ml), The precipitate was filtered off, and the supernatant was passed through a D101 macroporous resin column (the amount of macroporous resin was 4kg, the inner diameter was 15cm, and the length of the column was 70cm), and the impurities were washed away with 2 times column volume (BV) distilled water, and then 2BV60% ethanol solution was used for elution. The eluted part is collected, ethanol is recovered, and the concentrate is spray-dried at 60° C. to obtain a yellow-brown powder, which is the extract of the Radix Acanthus Radix of the present invention.

[0032] 2. Fingerprint analysis

[0033] 2.1 Analy...

Embodiment 2

[0041] Embodiment 2 The preparation of the Radix Acanthopanax bark extract of the present invention

[0042] 1. Preparation method

[0043] Weigh 4 kg of Radix syringae medicinal material, soak in water overnight, add 15 times the amount of water to decoct 3 times (decoction time is 30min), combine the decoction, heat and evaporate to a small volume (concentrate to 5000ml), filter To remove the precipitate, the supernatant was passed through a D101 macroporous resin column (the amount of macroporous resin was 4kg, the inner diameter was 15cm, and the length of the column was 70cm), and the impurity was washed away with 2 times column volume (BV) distilled water, then 3BV40% ethanol solution was eluted, and collected The ethanol is recovered from the eluted part, and the concentrate is spray-dried at 60° C. to obtain a yellow-brown powder, which is the extract of the Radix Acanthus Radix of the present invention.

[0044] 2. Fingerprint analysis

[0045] 2.1 Analysis method ...

Embodiment 3

[0049] Embodiment 3 The preparation of the Radix Acanthopanax bark extract of the present invention

[0050] 1. Preparation method

[0051] Weigh 4 kg of Radix syringae medicinal material, soak in water overnight, add 15 times the amount of water to decoct 3 times (decoction time is 30min), combine the decoction, heat and evaporate to a small volume (concentrate to 5000ml), filter To remove the precipitate, the supernatant was passed through a D101 macroporous resin column (the amount of macroporous resin was 4kg, the inner diameter was 15cm, and the length of the column was 70cm), and the impurity was washed away with 2 times column volume (BV) distilled water, and then 3BV20% ethanol solution was eluted, and collected The ethanol is recovered from the eluted part, and the concentrate is spray-dried at 60° C. to obtain a yellow-brown powder, which is the extract of the Radix Acanthus Radix of the present invention.

[0052] 2. Fingerprint analysis

[0053] 2.1 Analysis method...

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Abstract

The invention discloses a girald acanthopanax bark extract which is an extract of girald acanthopanax barks. An HPLC (high performance liquid chromatography) fingerprint spectrum of the girald acanthopanax bark extract is as shown in a figure 2, a figure 3 or a figure 4, chromatography conditions of the HPLC fingerprint spectrum are that chromatographic columns: octadecylsilane chemically bonded silica serves as filling agents; detecting wavelength: the detecting wavelength is 207nm; flowing phases: 0.3% of sodium dihydrogen phosphate water solution serves as a flowing phase A, and acetonitrile serves as a flowing phase B. The girald acanthopanax bark extract has excellent functions of resisting inflammation and easing pain and is excellent in effect and application prospect.

Description

technical field [0001] The invention relates to an extract of the bark of the five-fingered root and its preparation method and application. Background technique [0002] Acanthopanax, first recorded in "Shen Nong's Materia Medica", "The Classic" records: "a jackal lacquer", which is the earliest synonym of Acanthopanax. "Bielu of Famous Doctors" contains: "A Jackal Festival". "Tu Jing Materia Medica" contains: "Brewing wine and drinking it can cure wind numbness and limb spasms." "Compendium of Materia Medica" says: "Wujia cures rheumatism and impotence, strengthens muscles and bones, and its merits are profound." It can be seen that all the herbal medicines of the past dynasties have used Wujiapi as a good medicine for treating rheumatic arthralgia, and it has the effect of nourishing and strengthening. The medicinal base of Radix Acanthopanax in China originally comes from the stem bark or root bark of various plants of the genus Acanthopanax. [0003] The bark of Aca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P29/00A61P19/02
CPCA61K36/254A61K2236/331A61K2236/55
Inventor 古锐钟世红
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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