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Preparation method of bacterium-sensitive intelligent antibacterial coating and application

An antibacterial coating, intelligent technology, applied in the field of intelligent antibacterial coating and its application in orthopedic implants, and the preparation of antibacterial coating, can solve the problem of not taking into account the problem of bacterial drug resistance, and achieve the reduction of bacterial Possibility of drug resistance, increased sensitivity, and wide-ranging bactericidal effects

Active Publication Date: 2018-01-19
JIANGSU GUGELANSHAN PROTECTIVE FACILITIES CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the antibacterial materials prepared above are all single-stimuli-responsive antibacterial materials, and the problem of bacterial drug resistance is not considered.

Method used

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  • Preparation method of bacterium-sensitive intelligent antibacterial coating and application
  • Preparation method of bacterium-sensitive intelligent antibacterial coating and application
  • Preparation method of bacterium-sensitive intelligent antibacterial coating and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Bacteria-sensitive intelligent antibacterial coating of the present invention, the steps are as follows:

[0042] 1. Preparation of Mesoporous Silica Films

[0043] First, configure the precursor solution: 80 μL of tetraethyl orthosilicate, 0.16 g of cetyltrimethylammonium bromide, 30 mL of ethanol, 70 mL of deionized water, 10 μL of ammonia water; secondly, 316L stainless steel (1×0.5cm 2 ) immersed in the precursor solution at 60°C for 15 days; finally, the sample was taken out, washed with an ethanol solution containing HCl (0.83mL 37wt% hydrochloric acid dissolved in 100mL ethanol), deionized water, and dried to obtain a silica film.

[0044] 2. Modification of Mesoporous Silica Film Surface with Functional Groups

[0045] Preparation of amino-modified film: Place the dried silica film on a copper grid in a flask, immerse in anhydrous toluene (5 mL), add aminopropyltriethoxysilane (20 μL / cm 2 , cm in the present invention 2 is the area of ​​stainless steel), he...

Embodiment 2

[0055] Bacteria-sensitive intelligent antibacterial coating of the present invention, the steps are as follows:

[0056] 1. Preparation of Mesoporous Silica Films

[0057] First, configure the precursor solution: 80 μL of tetraethyl orthosilicate, 0.16 g of cetyltrimethylammonium bromide, 30 mL of ethanol, 70 mL of deionized water, 10 μL of ammonia water; secondly, 316L stainless steel (1×0.5cm 2 ) was immersed in the precursor solution at 58°C for 20 days; finally, the sample was taken out, washed with an ethanol solution containing HCl (0.83mL 37wt% hydrochloric acid dissolved in 100mL ethanol), deionized water, and dried to obtain a silica film.

[0058] 2. Modification of Mesoporous Silica Film Surface with Functional Groups

[0059] Preparation of amino-modified film: Place the dried silica film on a copper grid in a flask, immerse in anhydrous toluene (5 mL), add aminopropyltriethoxysilane (20 μL / cm 2 ), heated to reflux, and stirred for 24 h. After the reaction, the...

Embodiment 3

[0069] Bacteria-sensitive intelligent antibacterial coating of the present invention, the steps are as follows:

[0070] 1. Preparation of Mesoporous Silica Films

[0071] First, configure the precursor solution: 80 μL of tetraethyl orthosilicate, 0.16 g of cetyltrimethylammonium bromide, 30 mL of ethanol, 70 mL of deionized water, 10 μL of ammonia water; secondly, 316L stainless steel (1×0.5cm 2 ) immersed in the precursor solution at 62°C for 15 days; finally, the sample was taken out, washed with an ethanol solution containing HCl (0.83mL 37wt% hydrochloric acid dissolved in 100mL ethanol), deionized water, and dried to obtain a silica film.

[0072] 2. Modification of Mesoporous Silica Film Surface with Functional Groups

[0073] Preparation of amino-modified film: Place the dried silica film on a copper grid in a flask, immerse in anhydrous toluene (5 mL), add aminopropyltriethoxysilane (20 μL / cm 2 ), heated to reflux, and stirred for 24 h. After the reaction, the sam...

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Abstract

The invention discloses a preparation method of a bacterium-sensitive intelligent antibacterial coating and an application, and belongs to the field of composite antibacterial materials. The preparation method comprises the steps as follows: firstly, a mesoporous silica film with two-dimensional pore channels perpendicular to a substrate is synthesized; then, organic functional modification is performed on the surface of the silica film; finally, the modified film and macrocyclic molecules form a nano-valve, and antibacterial drugs are encapsulated. When a host is infected with bacteria, the bacteria secrete a series of pathogenic factors to form special bacterial infection microenvironments, the special microenvironments are used as stimulating factors to prompt a drug-loading nano-container to release a drug, and selective delivery of antibiotics is achieved. With adoption of the strategy, selectivity and efficacy of the antibiotics can be increased significantly, toxic and side effects of the drug are reduced, the infection site is maintained at a higher drug concentration, and antibiotic resistance is overcome.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial coating, in particular to a bacteria-sensitive intelligent antibacterial coating and its application in orthopedic implants, belonging to the field of composite antibacterial materials. Background technique [0002] In daily life, bacteria are everywhere. For a long time, microorganisms such as bacteria as pathogenic bacteria have had a great impact on human life and health, not only endangering people's health, but even life in serious cases; on the other hand, microorganisms can also cause some materials to deteriorate, decompose, damage and cause serious economic losses. Implants in the body have been known to cause infections as far back as the fourteenth century, and until now, medical devices and devices implanted in the body such as urinary catheters, pacemakers, and knee and hip implants have ) still seriously affects the health of human beings. It will not only adversely affec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/34A61L27/30C08B37/16C01B33/12
Inventor 傅佳骏王婷朱发海朱青泽卢静
Owner JIANGSU GUGELANSHAN PROTECTIVE FACILITIES CO LTD
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