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Preparing method of carboxymethyl chitosan/graphene oxide/poly(N-isopropylacrylamide) nanocomposite hydrogel

A technology of isopropylacrylamide and carboxymethyl chitosan, which is applied in the field of preparation of carboxymethyl chitosan/graphene oxide/polymer nanocomposite hydrogel, can solve the problem of harsh conditions and technical problems of composite hydrogel. Complexity and other issues, to achieve the effect of improved mechanical properties, simple preparation method, and good biocompatibility

Active Publication Date: 2018-01-05
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the problems of harsh conditions and complex processes for preparing composite hydrogels in the prior art, and provide a carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel Glue preparation method

Method used

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Embodiment 1

[0034] A preparation method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel, the steps are as follows:

[0035] (1) At 16°C, carboxymethyl chitosan with a viscosity average molecular weight of 350,000 and a degree of substitution of 0.7 was added to the 2-morpholine ethanesulfonic acid solution of graphene oxide and stirred at a rate of 150 rpm for 12 h, wherein the oxidized The lateral size of the graphene sheet is 0.2um, the thickness is 0.8nm, the pH value of the 2-morpholineethanesulfonic acid solution is 4, and the concentration of graphene oxide in the 2-morpholineethanesulfonic acid solution of graphene oxide is 0.0001 g / mL, then added N-isopropylacrylamide monomer and photoinitiator 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, and stirred at 150rpm for 2h to obtain carboxyl Methyl chitosan / graphene oxide / N-isopropylacrylamide dispersion, the mass ratio of carboxymethyl chitosan, graphene oxide, N-isopropylacrylamide ...

Embodiment 2

[0047] A preparation method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel, the steps are as follows:

[0048] (1) At 20°C, carboxymethyl chitosan with a viscosity average molecular weight of 500,000 and a degree of substitution of 0.95 was added to the phosphate buffer solution of graphene oxide and stirred at a speed of 400 rpm for 24 hours, wherein the graphene oxide sheets were The lateral dimension of the layer is 1.5um, the thickness is 1.1nm, the pH value of the phosphate buffer is 6, the concentration of graphene oxide in the phosphate buffer of graphene oxide is 0.0006g / mL, and then N-isopropylpropene is added. Amide monomer and photoinitiator 1-hydroxycyclohexyl phenyl ketone / benzophenone, wherein the mass ratio of 1-hydroxycyclohexyl phenyl ketone to benzophenone is 1:1, and stirring at a speed of 400 rpm 5h to obtain carboxymethyl chitosan / graphene oxide / N-isopropylacrylamide dispersion, mass ratio of carboxymethyl chito...

Embodiment 3

[0060] A preparation method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel, the steps are as follows:

[0061] (1) At 18°C, carboxymethyl chitosan with a viscosity average molecular weight of 400,000 and a degree of substitution of 0.825 was added to the 2-morpholine ethanesulfonic acid solution of graphene oxide and stirred at a rate of 275 rpm for 18 h. The lateral size of the graphene sheet is 0.86um, the thickness is 0.95nm, the pH value of the 2-morpholineethanesulfonic acid solution is 5, and the concentration of graphene oxide in the 2-morpholineethanesulfonic acid solution of graphene oxide is 0.00035 g / mL, then added N-isopropylacrylamide monomer and photoinitiator 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, and stirred at 275rpm for 3.5h to obtain Carboxymethyl chitosan / graphene oxide / N-isopropylacrylamide dispersion, the mass ratio of carboxymethyl chitosan, graphene oxide, N-isopropylacrylamide monomer and phot...

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Abstract

The invention relates to a preparing method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel. In preparation, the method includes the steps of conducting even mixing to obtain carboxymethyl chitosan / graphene oxide / N-isopropylacrylamide dispersion liquid containing photoinitiator, adding an activating agent to obtain a mixed solution, making the mixed solution react under the room temperature and nitrogen protection conditions to obtain carboxymethyl chitosan / graphene oxide crosslinked and cured hydrogel, and finally conducting ultraviolet irradiationto obtain the carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel. The finally prepared nanocomposite hydrogel has the pH / temperature dual-response characteristic, has the water content of 80-92%, the maximum compressive strength of 0.6-0.8 MPa and the fracture strain of 75-85%, has the advantage of good biocompatibility, and has potential application value inthe fields of drug release, molecular devices and the like.

Description

technical field [0001] The invention belongs to the field of polymer materials and relates to a preparation method of carboxymethyl chitosan / graphene oxide / poly(N-isopropylacrylamide) nanocomposite hydrogel. Background technique [0002] Hydrogel is a kind of material made of a kind of hydrophilic cross-linked polymer three-dimensional network structure that can absorb a large amount of water and is insoluble in water. Due to its excellent biomimetic properties and biocompatibility, It has a wide range of applications in biomedical fields such as drug release, tissue engineering, and wound dressings. According to the different responses of hydrogels to external stimuli, they can be divided into two categories: traditional hydrogels and smart hydrogels. Among them, traditional hydrogels are insensitive to external responses, while smart hydrogels can sense the external environment. Subtle changes in ions, such as changes in temperature, pH, light, electric field, magnetic fi...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L33/24C08K3/04C08F120/54C08F220/54C08F222/38C08F2/48C08J3/075C08J3/28C08J3/24
Inventor 于俊荣陈阳胡祖明王彦诸静宋逸文
Owner DONGHUA UNIV
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