Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition for suppressing muscular fatty change

A technology of muscle fat and composition, which is applied in the field of composition for inhibiting muscle fat formation, can solve the problem of no inhibition of muscle satellite cell differentiation, and achieve the effect of improving muscle mass, high safety, and improving muscle strength

Inactive Publication Date: 2018-01-02
SUNTORY HLDG LTD
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, no components that inhibit the differentiation of muscle satellite cells into adipocyte-like cells have been found so far

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition for suppressing muscular fatty change
  • Composition for suppressing muscular fatty change
  • Composition for suppressing muscular fatty change

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Example 1: Fat accumulation inhibitory effect by quercetin

[0081] (1) Isolation of muscle satellite cells

[0082] The gastrocnemius, soleus, tibialis anterior, extensor digitorum longus, and quadriceps muscles were extracted from 10- to 14-week-old Fischer344 rats under anesthesia and chopped. The tissue was enzymatically decomposed with protease (Sigma-Aldrich), and then centrifuged to obtain a precipitate. The obtained precipitate was suspended in modified Eagle medium (DMEM) containing 10% fetal horse serum, and seeded on 8-well microscope slides (BD Thermo Scientific Company) as muscle satellite cells to become 5 × 10 4 ~7×10 4 cells / mL.

[0083] (2) Induction of differentiation into adipocyte-like cells

[0084] The isolated muscle satellite cells were cultured with F-10 (GIBCO) containing 20% ​​bovine serum for 72 hours. Thereafter, the cells were cultured for 72 hours in an adipogenic induction medium (Lonza) containing 0.1% DMSO (control), 5 µM quercetin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention addresses the problem of providing: a novel composition for suppressing muscular fatty change, which contains a component that can be ingested safely for a long period; and others. It is found that quercetin or a glycoside thereof can suppress the process of the differentiation of a muscle satellite cell into an adipocyte-like cell. In the present invention, quercetin or a glycoside thereof is used in a composition for suppressing muscular fatty change and the like.

Description

technical field [0001] The present invention relates to a composition for inhibiting muscle fat formation containing quercetin or a glycoside thereof. In addition, the present invention relates to a composition for inhibiting muscle fat formation, a composition for improving muscle mass, a composition for improving muscle strength, a composition for inhibiting muscle atrophy, and a composition for improving motor function, characterized in that it contains quercetin or its glycosides, and inhibit the differentiation of muscle satellite cells into adipocyte-like cells. Furthermore, the present invention also relates to the use of quercetin or its glycoside for inhibiting the differentiation process of muscle satellite cells into adipocyte-like cells and the inhibition of the differentiation process of muscle satellite cells into adipocyte-like cells using quercetin or its glycoside Methods. Background technique [0002] In a country with a high proportion of elderly people ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/7048A61P21/00A61P43/00
CPCA61K31/352A61K31/7048A61P21/00A61P43/00C07D311/30A61K31/353
Inventor 大塚祐多神崎范之町田修一
Owner SUNTORY HLDG LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com