Pharmaceutical composition for preventing and treating RA (rheumatoid arthritis)

A kind of composition and arthritic technology, applied in the field of Chinese patent medicine

Inactive Publication Date: 2017-12-29
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Make decoction of the above medicine and take it orally, one dose per day; CN101468136 patent application discloses 12g of Angelica, 10g of Radix Paeoniae Alba, 10g of Cortex Wujiapi, 15g of Dipsacus Radix, 8g of Huangda, 12g of Clematis, 7g of Chuanhuanglian, Akebia 5g, Epimedium 10g, Snake 3g, Scorpion 5g, Achyranthes bidentata 10g, Guizhi 12g, Myrrh 10g, Duhuo 5g, Anemarrhena 10g, Atractylodes 6g, Fangfeng 15g, Nuxychia 10g, bone fragments The traditional Chinese medicine preparation for the treatment of RA made by adding 15g; CN101601818 patent application discloses 24-66 parts of angelica, 35-75 parts of Gastrodia elata, 24-66 parts of Achyranthes bidentata, 35-75 parts of safflower, 24-66 parts of myrrh, 12 to 48 parts of frankincense, 12 to 48 parts of atractylodes rhizome, 12 to 48 parts of notopterygium, and 24 to 66 parts of lovage are medicinal preparations for the treatment of RA made of raw materials; 6-12), donkey-hide gelatin (6-12), jujube kernel (9-15), Xu Changqing (9-18), asarum (2-5), angelica (9-15), cinnamon (2-5), clove (3-8), Black Snake (5-10), White Snake (3-6), Qianghuo (9-15), Duhuo (9-15), Xungufeng (9-18), Bergamot (9-15) 18), licorice (3-9), ligusticum edulis (9-15) and myrrh (6-10), mix the above-mentioned traditional Chinese medicines according to the proportion, grind them through a 60-100 mesh sieve, and make powder according to the routine , sterilize the Chinese medicine powder that is crushed into fine powder and put it into capsules, each capsule is 0.45 grams of Chinese medicine capsules; the formation and development of rheumatoid arthritis is an extremely complicated process. However, there is still no conclusion. Therefore, it is the desire of the majority of patients to develop a traditional Chinese medicine compound prescription for the treatment of rheumatoid arthritis with simple and effective medicine.

Method used

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  • Pharmaceutical composition for preventing and treating RA (rheumatoid arthritis)
  • Pharmaceutical composition for preventing and treating RA (rheumatoid arthritis)
  • Pharmaceutical composition for preventing and treating RA (rheumatoid arthritis)

Examples

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Effect test

example 1

[0057] Example 1 (granules)

[0058] Prescription: Snakevine 30g, Rhodiola rosea 30g, Dipsacus 15g, Motherwort 15g.

[0059] Preparation method: Extract the raw material drug with water twice according to the prescription, add 10 times of water for the first time and decoct for 1 hour, add 5 times of water for the second time and decoct for 0.5 hour, then combine the decoction liquid, filter, and finally concentrate the filtrate to For the extract with a relative density of 1.41 at 60°C, first add 2 times the weight of dextrin according to the weight of the extract, dry it in vacuum at 80°C, grind it through a 65-mesh sieve to obtain a dry powder, and use 95% ethanol as a wetting agent to make a soft material. Pass through a 16-mesh sieve to granulate, dry, granulate, and pack into 10g packs.

[0060] Dosage: 20g each time, 3 times a day, take it with warm water.

example 2

[0061] Example 2 (tablet)

[0062] Prescription: Snakevine 40g, Rhodiola rosea 15g, Dipsacus 25g, Motherwort 10g.

[0063] Preparation method: Extract the raw material drug with water twice according to the prescription, add 10 times of water for the first time and decoct for 1 hour, add 5 times of water for the second time and decoct for 0.5 hour, then combine the decoction liquid, filter, and finally concentrate the filtrate to For the extract with a relative density of 1.46 at 60°C, first add 2 times the weight of dextrin according to the weight of the extract, dry it in vacuum at 80°C, grind it through a 65-mesh sieve to obtain a dry powder, and use 95% ethanol as a wetting agent to make a soft material. Granulate through a 16-mesh sieve, dry, and compress into tablets by conventional methods to make tablets.

[0064] Dosage: Take orally, 5 tablets at a time, 3 times a day.

example 3

[0065] Example 3 (capsules)

[0066] Prescription: Snakevine 20g, Rhodiola rosea 42g, Dipsacus 20g, Motherwort 8g.

[0067] Preparation method: Extract the raw material drug with water twice according to the prescription, add 10 times of water for the first time and decoct for 1 hour, add 5 times of water for the second time and decoct for 0.5 hour, then combine the decoction liquid, filter, and finally concentrate the filtrate to For the extract with a relative density of 1.45 at 60°C, first add 2 times the weight of dextrin according to the weight of the extract, dry it in vacuum at 80°C, grind it through a 65-mesh sieve to obtain a dry powder, and use 95% ethanol as a wetting agent to make a soft material. Pass through a 16-mesh sieve to granulate, dry, granulate, and pack into gelatin capsules to make capsules.

[0068] Dosage: Take orally, 5 capsules at a time, 3 times a day.

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Abstract

The invention relates to Chinese patent medicines prepared from plants, in particular to pharmaceutical composition for preventing and treating RA (rheumatoid arthritis). The pharmaceutical composition is prepared from an effective component and pharmaceutically acceptable auxiliary materials, and is characterized in that the effective component is prepared from raw materials in percentage by weight as follows: 22%-45% of celastrus orbiculatus stem, 16%-47% of herba rhodiolae, 10%-28% of radix dipsaci and 8%-28% of herba leonuri. The four medicines cooperate to have the effects of removing wind and damp, promoting blood circulation and strengthening bones and muscles and have the advantages of being easily available and moderate in cost.

Description

field of invention [0001] The invention relates to a medical preparation, in particular to a Chinese patent medicine with plants as raw materials. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune disease mainly manifested by chronic inflammatory lesions in joints and periarticular tissues, which seriously endangers human health and is a frequently-occurring and difficult disease in clinical practice. According to statistics, the incidence rate in foreign countries is about 1% to 2%, and it is as high as 5% in some regions. The incidence rate in various parts of our country is slightly different, with an average of 0.4%. Based on this incidence rate, the total number of patients in my country is as high as 4 to 5 million. It has been reported that the disability rate of RA patients who are not diagnosed and treated in time reaches 50% in two years and 70% in three years. Compared with their peers, the life expectancy of RA patients is shortened by 10-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61P19/02A61P29/00
CPCA61K36/185A61K36/37A61K36/41A61K36/533A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 林昌松刘清平徐强关彤雷旭杰刘敏莹刘明岭张明英刘丽娟陈纪藩刘艳艳李楠潘东梅姜玉宝魏赈权刘小宝王强
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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