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Intestinal environment-improving agent

A technology for improving agent and internal environment, which is applied in the direction of digestive system, urinary system diseases, nervous system diseases, etc. It can solve the problems such as the number of hard-to-residence and hard-to-live bacteria, and achieve the effect of reducing spoilage products and improving the excellent intestinal environment Effect

Inactive Publication Date: 2017-12-29
TAISHO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, probiotics (probiotics) containing live bacterial preparations of the genus Bifidobacterium, food, etc. are also known. However, before the genus Bifidobacterium reaches the large intestine, it is killed in gastric acid and bile acid, so it is difficult to enter the intestinal tract. maintain the number of live bacteria ingested
In addition, live bacteria administered externally are temporarily fixed in the intestines, but it is difficult to permanently reside in the intestines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0090] Granules containing the following ingredients were manufactured.

[0091] (prescription)

[0092] Ingredient Compound [I] 10mg

[0093] Lactose 700mg

[0094] Corn starch 274mg

[0095] the HPC-L 16mg

[0096] 1000mg.

[0097] (preparation method)

[0098]Compound [I] and lactose were passed through a 60-mesh sieve. Pass the cornstarch through a 120-mesh sieve. Mix them with a V-blender. Add low-viscosity hydroxypropyl cellulose (HPC-L) aqueous solution to the mixed powder, stir, granulate (extrusion granulation aperture 0.5-1mm), and then dry. The obtained dry granules are sieved with a vibrating sieve (12 / 60 mesh) to obtain granules.

preparation example 2

[0100] A powder for capsule filling containing the following ingredients is produced.

[0101] Ingredient Compound [I] 10mg

[0102] Lactose 79mg

[0103] Corn starch 10mg

[0104] the Magnesium stearate 1mg

[0105] 100mg.

[0106] (preparation method)

[0107] Compound [I] and lactose were passed through a 60-mesh sieve. Pass the cornstarch through a 120-mesh sieve. They are mixed with magnesium stearate with a V-blender. Fill 10 times powder 100mg into No. 5 hard gelatin capsules.

preparation example 3

[0109] Granules for capsule filling containing the following ingredients are produced.

[0110] Ingredient Compound [I] 15mg

[0111] Lactose 90mg

[0112] Corn starch 42mg

[0113] the HPC-L 3mg

[0114] 150mg.

[0115] (preparation method)

[0116] Compound [I] and lactose were passed through a 60-mesh sieve. Pass the cornstarch through a 120-mesh sieve. These were mixed with a V-type mixer. Add low-viscosity hydroxypropyl cellulose (HPC-L) aqueous solution to the mixed powder, stir, granulate, and then dry. The obtained dried granules were sieved with a vibrating sieve (12 / 60 mesh), sized, and 150 mg thereof were filled into No. 4 hard gelatin capsules.

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PUM

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Abstract

Provided are an intestinal environment-improving agent containing as an active ingredient a compound represented by formula [I] or a pharmaceutically acceptable salt thereof, and a novel medicine useful in the prevention or treatment of conditions such as hepatic encephalopathy and uremia.

Description

technical field [0001] The present invention relates to drugs useful for improving intestinal environment. In more detail, it relates to a drug useful for improvement of intestinal environment, treatment of hepatic encephalopathy, etc., treatment of uremia, and the like. Background technique [0002] The number of bacteria constituting the human intestinal flora is estimated to be more than 100 trillion, and there are about 1,000 species in terms of species. Each person is composed of 200 to 300 species, forming an intestinal flora and living in symbiosis with humans. In recent years, the relationship between intestinal bacteria and diseases has attracted attention, and not only the relationship with digestive system diseases, but also the relationship with various diseases such as allergies, diabetes, obesity, and depression has been reported (Non-Patent Documents 1 and 2) . [0003] The intestinal flora is composed of 3 types of intestinal bacteria: beneficial bacteria (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/351A61P1/16A61P25/00A61P13/00
CPCA61K31/351A61P1/16A61P1/00A61P25/00A61P13/12
Inventor 井尾房代山本大辅山本浩二
Owner TAISHO PHARMACEUTICAL CO LTD
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