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Aesculetin with anti-oxidative and anti-aging activity as well as preparation method and application

An anti-aging technology, used in organic chemistry, skin care preparations, anti-toxic agents, etc., can solve problems such as genetic deformity, skin aging, skin function decline, etc., to achieve stable product performance and delay skin cells. Aging, high content effect

Inactive Publication Date: 2017-12-22
FOSHAN SANSHUI DISTRICT JIAHUA CHEM RES INST GENERAL PARTNERSHIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, due to the influence of internal factors such as age, diet and living habits, it leads to the decline of skin function and genetic abnormalities, which makes the skin more prone to aging.

Method used

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  • Aesculetin with anti-oxidative and anti-aging activity as well as preparation method and application
  • Aesculetin with anti-oxidative and anti-aging activity as well as preparation method and application
  • Aesculetin with anti-oxidative and anti-aging activity as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of acetaminophen with anti-oxidation and anti-aging activity, comprising the following preparation steps:

[0025] (1) The remaining residue after water extraction of Qinpi is dried, sterilized by ultraviolet radiation for 30 minutes, and taken out;

[0026] (2) With 3% Geotrichum candidum as fermentation bacteria, 0.5% glucose as fermentation aid, 32°C constant temperature ventilation as fermentation condition, fermentation time is 5 hours, and 8 times of weight parts of distilled water are added to the sterilized Qinpi residue Carry out fermentation, and after the fermentation is finished, take out the sample, dry and pulverize, pass through a 30-mesh sieve to obtain the fermented Qinpi residue powder;

[0027] (3) Add n-butane to the fermented Qinpi residue powder according to the material-to-liquid ratio of 1:25 to carry out reflux extraction for 3 times, each time for 45 minutes, combine the extracts, filter, recover the organic extractant unde...

Embodiment 2

[0030] A preparation method of acetaminophen with anti-oxidation and anti-aging activity, comprising the following preparation steps:

[0031] (1) The remaining residue after water extraction of Qinpi is dried, sterilized by ultraviolet radiation for 30 minutes, and taken out;

[0032] (2) With the sterilized bark residue, use 2% Geotrichum candidum as fermentation bacteria, 0.2% glucose as fermentation aid, 32°C constant temperature and ventilation as fermentation conditions, fermentation time is 4 hours, add 8 times the weight of distilled water Carry out fermentation, and after the fermentation is finished, take out the sample, dry and pulverize, pass through a 30-mesh sieve to obtain the fermented Qinpi residue powder;

[0033] (3) Add n-butane to the fermented Qinpi residue powder according to the material-to-liquid ratio of 1:20 to carry out reflux extraction for 3 times, each time for 30 minutes, combine the extracts, filter, recover the organic extractant under reduced...

Embodiment 3

[0036] A preparation method of acetaminophen with anti-oxidation and anti-aging activity, comprising the following preparation steps:

[0037] (1) The remaining residue after water extraction of Qinpi is dried, sterilized by ultraviolet radiation for 30 minutes, and taken out;

[0038] (2) With the sterilized bark residue, use 4% Geotrichum candidum as fermentation bacteria, 1% glucose as fermentation aid, 32°C constant temperature and ventilation as fermentation conditions, fermentation time is 6 hours, add 8 times the weight of distilled water Carry out fermentation, and after the fermentation is finished, take out the sample, dry and pulverize, pass through a 30-mesh sieve to obtain the fermented Qinpi residue powder;

[0039] (3) Add n-butane to the fermented Qinpi residue powder according to the solid-to-liquid ratio of 1:30 to carry out reflux extraction for 3 times, each time for 60 minutes, combine the extracts, filter, recover the organic extractant under reduced pres...

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Abstract

The invention discloses aesculetin with anti-oxidative and anti-aging activity as well as a preparation method and an application of aesculetin. The preparation method comprises preparation steps as follows: (1), cortex fraxini residues are dried, sterilized for 30 min under ultraviolet irradiation and taken out; (2), distilled water which is 8 times the sterilized cortex fraxini residues in parts by weight is added to the sterilized cortex fraxini residues for fermentation, after fermentation, a sample is taken out, dried, smashed and screened by a 30-mesh sieve, and fermented cortex fraxini residue powder is obtained; (3), an organic extracting agent is added to the fermented cortex fraxini residue powder for reflux extraction, extracting solutions are combined, a combined solution is filtered, and the organic extracting agent is subjected to reduced-pressure recovering and concentrated into thick paste; (4), distilled water is added to the thick paste for dilution, heating dissolution is performed, an obtained solution is filtered while still hot, and a filtrate is separated, purified and decolorized and then is subjected to reduced-pressure concentration and freeze drying finally. Aesculetin has a function of eliminating oxygen free radicals, has a protecting effect on cell DNA oxidative damage caused by lipid peroxide and can effectively delay skin cell senescence.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a tercetine with anti-oxidation and anti-aging activities, a preparation method and an application thereof. Background technique [0002] The skin is very vulnerable to damage due to direct contact with the external environment and being affected by various factors such as oxidation, dryness and ultraviolet rays. At the same time, due to the influence of internal factors such as age, diet and living habits, skin function declines and genetic abnormalities lead to aging of the skin. One of the most important factors of skin aging is skin photoaging caused by long-term exposure to ultraviolet radiation. Photoaging of the skin is due to the increase of free radicals in the skin, which can damage the biofilm, promote the increase and amorphization of elastin fibers, and the significant reduction of collagen fibers and the increase of glucosaminoglycans and other skin aging phenomena. Fight...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16A61K8/49A61Q19/08A61Q17/04A61P39/06
CPCC07D311/16A61K8/498A61Q17/04A61Q19/08
Inventor 不公告发明人
Owner FOSHAN SANSHUI DISTRICT JIAHUA CHEM RES INST GENERAL PARTNERSHIP
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