Application of black phosphorus nanosheet

Abstract

The invention discloses a black phosphorus nano material for treating Alzheimer's disease, wherein a black phosphorus nanosheet is prepared from black phosphorus powder by an ultrasonic liquid peeling process. Moreover, the invention also discloses a preparation method and application of the nano material. According to the invention, the black phosphorus nanosheet for treating Alzheimer's disease can be used as a nano acquirer for effectively and selectively acquiring Cu<2+>, so as to reduce generation of active oxygen in cells and protect the cells from the toxicity related to non-dynamic balance of the Cu<2+>. According to the black phosphorus nanosheet medicine for treating Alzheimer's disease disclosed by the invention, the blood-brain barrier permeability can be improved through a photothermal effect, the shortcomings that a small-molecule compound or polypeptide cannot pass through blood-brain barrier and is unstable are overcome, and the efficacy is improved. The nanomaterial has the advantages of simple preparation process, no additional drug load, high stability and high biocompatibility, and thus has excellent biosecurity when used for treating Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of preparation of medical materials; in particular, it relates to the application of black phosphorus nanosheets in the preparation of nanomedicine for treating Alzheimer's disease. Background technique [0002] Black phosphorus, as a new type of layered material, is called phosphorene because of its crystal structure similar to graphene, and has received extensive attention in the past few years. It is a honeycomb wrinkled structure, and the van der Waals force between layers is relatively weak, and single-layer nanosheets can be obtained by ultrasonic stripping. Unlike graphene, the energy bandgap of black phosphorus nanosheets (BP) is related to its thickness. The energy bandgap of bulk BP is about 0.3eV, while that of single-layer BP nanosheets is 2.0eV. In addition, because BP nanosheets have high electron mobility, planar anisotropy, and can absorb wavelengths from ultraviolet to the entire visible range, they ...

AI Technical Summary

Problems solved by technology

However, the neuroprotective molecules that have been developed that integrate metal chelating and antioxidant properties cannot cross the blood-brain barrier (BBB); while liposomes, nanovesicles, polymer nano However, due to the laborious drug loading and cumbersome preparation process, their clinical application is limited.

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