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Method for preparing anticoagulant composite coating

A composite coating and anti-coagulation technology, which is applied in coatings, pharmaceutical formulations, surgery, etc., can solve the problems of anti-coagulation effects, high cost, and difficulty in meeting clinical requirements, and achieve prolongation of thromboplastin time, Excellent biocompatibility, excellent anticoagulant effect

Inactive Publication Date: 2017-12-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bulk modification is more complicated, difficult to implement, and costly. The anticoagulant effect is easily affected during the processing and molding process, and it is difficult to meet clinical requirements.

Method used

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  • Method for preparing anticoagulant composite coating
  • Method for preparing anticoagulant composite coating
  • Method for preparing anticoagulant composite coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A method for modifying PVC sheet with anticoagulant composite coating, the specific steps are as follows:

[0030] Dissolve 50mg of polyvinyl alcohol 1788 in 5ml of deionized water and dissolve in a constant temperature water bath at 50°C, add 25mg of polyvinylpyrrolidone under stirring conditions, and add 2.5mg of heparin sodium when it is completely dissolved; add 5mg of chitosan into 5ml of deionized water, Add 50-100ul of glacial acetic acid dropwise under stirring until the solution is clear. After uniformly mixing the above two solutions, 200-500 ul of glutaraldehyde solution with a concentration of 2.5% by mass was added dropwise under the condition of stirring, and then 10 mg of glycerin was added and stirred evenly to obtain an anticoagulant and anticoagulant composite coating. Clean the PVC sheet with a size of 2 × 2 (cm) with medical alcohol, vacuum dry it with 1% silane coupling agent N-(β-aminoethyl)-γ-aminopropyltrimethoxy After immersing in the base sila...

Embodiment 2

[0032] A method for modifying PVC sheet with anticoagulant composite coating, the specific steps are as follows:

[0033] Dissolve 100mg of polyvinyl alcohol 1788 in 5ml of deionized water and dissolve in a constant temperature water bath at 50°C, add 50mg of polyvinylpyrrolidone under stirring conditions, and add 5mg of heparin sodium when it is completely dissolved; add 25mg of chitosan into 5ml of deionized water, Add 100-200ul of glacial acetic acid dropwise under stirring until the solution is clear. After uniformly mixing the above two solutions, add 200-500 ul of glutaraldehyde solution with a mass percent concentration of 2.5% dropwise under stirring conditions, and then add 25 mg of glycerin and stir evenly to obtain an anticoagulant and anticoagulant composite coating. Clean the PVC sheet with a size of 2 × 2 (cm) with medical alcohol, vacuum dry it with 1% silane coupling agent N-(β-aminoethyl)-γ-aminopropyltrimethoxy After immersing in the base silane solution for...

Embodiment 3

[0035] A method for modifying PVC sheet with anticoagulant composite coating, the specific steps are as follows:

[0036] Dissolve 200mg of polyvinyl alcohol 1788 in 5ml of deionized water and dissolve in a constant temperature water bath at 50°C, add 100mg of polyvinylpyrrolidone under stirring conditions, and add 5mg of heparin sodium when it is completely dissolved; add 30mg of chitosan into 5ml of deionized water, Add 100-200ul of glacial acetic acid dropwise under stirring until the solution is clear. After uniformly mixing the above two solutions, add 200-500 ul of glutaraldehyde solution with a mass percent concentration of 2.5% dropwise under stirring conditions, and then add 20 mg of glycerin and stir evenly to obtain an anticoagulant and anticoagulant composite coating. Clean the PVC sheet with a size of 2 × 2 (cm) with medical alcohol, vacuum dry it with 1% silane coupling agent N-(β-aminoethyl)-γ-aminopropyltrimethoxy After immersing in the base silane solution fo...

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Abstract

The invention discloses a method for preparing an anticoagulant composite coating. The method for preparing the anticoagulant composite coating comprises the steps of first using a coupling agent to process the surface of a pre-processed biomedical base material to obtain a hydrophilic surface, using a specific anticoagulant composite coating to modify the biomedical base material, and obtaining a biomedical material having good anticoagulation property after drying. Studies have shown that the biomedical material modified by the anticoagulant composite coating is greatly improved in hydrophilicity and shows excellent biocompatibility. The modified material can not only maintain its original physical and mechanical properties, but also greatly extend activated partial thromboplastin time (APTT) in the coagulation test to show excellent anticoagulant properties.

Description

technical field [0001] The invention belongs to the technical field of anticoagulant materials, and relates to a method for preparing an anticoagulant composite coating, in particular to a method for modifying a biomedical substrate by using a specific anticoagulant composite coating. Background technique [0002] Biomedical materials refer to non-living materials that are used to contact living tissues and achieve certain functions for the purpose of treating diseases. Biomedical materials interact with biological systems to diagnose, repair or replace tissues in living bodies, Organs or their functions are closely related to human life and health. [0003] When biomedical materials need to be in contact with blood, not only biomedical materials are required to have good physical and chemical properties, but also biomedical materials are required to have good blood compatibility without hemolysis, coagulation, and thrombus. Anticoagulant biomedical materials are an importa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/00A61L31/16
CPCA61L31/00A61L31/042A61L31/048A61L31/16A61L2300/42A61L2400/18A61L2420/06C08L29/04C08L39/06C08L5/08C08L5/10
Inventor 王秀芬杨阳
Owner BEIJING UNIV OF CHEM TECH
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