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Bock greenbrier rhizome soft capsule and its preparation method

A technology of soft capsules and King Kong, which is applied in capsule delivery, microcapsules, pharmaceutical formulations, etc. It can solve problems such as inability to withstand high temperature, light, unstable properties of extracts, and inability to mask taste, etc., to achieve good appearance and stable products. Good sex and remarkable effect

Inactive Publication Date: 2017-12-01
ZHEJIANG ASEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extract of King Kongteng has a special smell of traditional Chinese medicine, and the properties of the extract are unstable and cannot withstand high temperature, light, etc., making it into tablets or solutions cannot cover up its taste, and the tablet is often slow due to the dissolution rate of the drug. However, it affects the full absorption of the drug; although the syrup-based liquid preparation is convenient to take, it has disadvantages such as inconvenient transportation and storage and high packaging costs.

Method used

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  • Bock greenbrier rhizome soft capsule and its preparation method
  • Bock greenbrier rhizome soft capsule and its preparation method
  • Bock greenbrier rhizome soft capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] King Kong vine 7500g corn oil and beeswax total 500g

[0039] [Technology] Squeeze and crush the Chinese herbal raw material King Kong vine, add water to decoct twice, add 7-10 times of water for 1-2 hours for the first time, add 6-9 times of water for 1-2 hours for the second time, combine Decoction, filter, concentrate the filtrate to a relative density of 1.2-1.3 (80°C), let cool, add ethanol, stand still, filter, recover the ethanol from the filtrate and concentrate, spray dry, add corn oil, appropriate amount of beeswax, mix well to prepare Into 1000 softgels.

Embodiment 2

[0041] King Kong vine 5000g soybean oil and beeswax total 500g

[0042] Its preparation method is as follows:

[0043] Squeeze and crush the Chinese herbal raw material King Kong vine, add water and decoct twice, add 7 times of water for the first time and decoct for 1 hour, add 6 times of water for the second time and decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate to relative density 1.2-1.3 (80°C), let cool, add ethanol, stand still, filter, recover ethanol from the filtrate and concentrate, spray dry, add soybean oil and appropriate amount of beeswax, mix well to prepare 1000 soft capsules.

Embodiment 3

[0045] King Kong vine 7500g corn oil and beeswax total 250g

[0046] Its preparation method is as follows:

[0047] Add water to decoct Rattan Vajras, the raw material of traditional Chinese medicine, twice, add 8 times of water for 2 hours for the first time, add 7 times of water for 2 hours for the second time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.2-1.3 (70°C), let cool, add ethanol, stand still, filter, recover ethanol from the filtrate and concentrate, spray dry, add corn oil, appropriate amount of beeswax and mix to prepare 1000 soft capsules.

[0048] The pharmaceutical research results of the soft capsule product provided by the invention are as follows:

[0049] 1. Long-term stability of Jingangteng Soft Capsules

[0050] Brown iron oxide is an edible pigment with light-shielding effect. Adding it into the capsule skin can help shade, prevent the photodecomposition of the drug, improve the stability of the drug, and e...

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Abstract

The invention relates to a bock greenbrier rhizome soft capsule and its preparation method, belongs to the technical field of traditional Chinese medicine. The bock greenbrier rhizome soft capsule is prepared by taking bock greenbrier rhizome water extractive as medicinal composition, matching ingredient solvent matrix and beewax to form content, and taking brown ferric oxide as main component of an external capsule cover. The soft capsule is featured by fast disintegration speed, high bioavailability and good product stability. Meanwhile, the preparation method of the water extractive can improve the content of effective component diosgenin; therefore, the drug effect of the soft capsule is more significant.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation capable of clearing heat and detoxification, reducing swelling and dispelling stagnation, and can be used for adnexitis and adnexal inflammatory mass. The preparation is made from raw materials of jingangteng traditional Chinese medicine and medicinal auxiliary materials. Background technique [0002] King Kongteng ("Chinese herbal medicine commonly used in Tibet"), also known as sarsaparilla, iron water chestnut, magalle, sinew and bone pillar, red light fruit, cold rice head, iron thorn Ling, diamond root, is the rhizome of Liliaceae Smilax chinensis. It mainly contains diosgenin, methyl fiber diosgenin, diosgenin, prosapogenin of diosgenin, kaempferol, smilaxin, oleanolic acid, etc. It has the effects of expelling wind, promoting blood circulation and detoxification. [0003] The theory of traditional Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61K9/48A61K47/44A61K47/02A61P15/00
CPCA61K9/4808A61K9/4816A61K9/4825A61K9/5015A61K36/896A61K36/90A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 邓金明吴海英王炯
Owner ZHEJIANG ASEN PHARMA
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