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Hyaluronic acid sterilization contraception gel and preparation method

A technology of hyaluronic acid and gel, which is applied in the direction of pharmaceutical formulations, local antibacterial agents, and medical preparations with non-active ingredients, etc., can solve problems such as rupture, affect the balance of the body, and lower body resistance, and reduce reproductive tract infections and inflammatory response, restore self-cleaning and self-cleaning ability, and inhibit the effect of inflammatory stimulation

Inactive Publication Date: 2017-12-01
海盾医美科技(杭州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been reported that if such drugs are used extensively, for a long time and in large quantities, at the usual concentration of vaginal contraceptive preparations, such drugs may cause damage and rupture of the vaginal and cervical epithelial mucosa, and cause pathogens such as Candida albicans and Staphylococcus aureus. Microbial invasion creates opportunities, so not only does it not have the function of contraception, but it is more likely to cause reproductive tract infection and inflammation; at the same time, this type of drug will also destroy the living environment of normal vaginal flora and affect the balance of the body, resulting in low body resistance and inflammation. The loss outweighs the gain

Method used

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  • Hyaluronic acid sterilization contraception gel and preparation method
  • Hyaluronic acid sterilization contraception gel and preparation method
  • Hyaluronic acid sterilization contraception gel and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0081] 1. Formula (weight ratio)

[0082]

[0083]

[0084] 2. Preparation method

[0085] a. Dissolve hyaluronic acid in 50g of sodium salt solution at 38°C, stir at 1500r / min for 3.4h, adjust pH to 5.5, add deionized water to 100 and mix evenly to prepare a 6.0% hyaluronic acid solution, Save for later use;

[0086] b. Take 400 grams of plant conditioner Fructus Cnidii, 300 grams of Gynostemma pentaphyllum, 100 grams of Stephania vine, and 200 grams of sage, mix and grind them into 1000 grams of coarse powder, add 10 times the amount of water, boil for 2 hours, filter, and add the filter residue 8 times the amount of water, boiled for 1 hour, and filtered; add 8 times the amount of water to the filter residue, boiled for 1 hour, filtered, the filtrates were combined, and concentrated under reduced pressure at 50 ° C to a clear liquid with a relative density of 1.0 g / ml. paste, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, recov...

Embodiment 3

[0091] 1. Formula (weight ratio)

[0092]

[0093] 2. Preparation method

[0094] a. Dissolve hyaluronic acid in 50g of sodium salt solution at 40°C, stir at 3000r / min for 4h, adjust pH to 5.5, add deionized water to 100 and mix evenly to prepare 8.0% hyaluronic acid solution, store spare;

[0095]b. Take 500 grams of plant conditioner Fructus Cnidii, 300 grams of Gynostemma pentaphyllum, 100 grams of Stephania vine, and 200 grams of sage, mix and grind them into 1000 grams of coarse powder, add 10 times the amount of water, boil for 2 hours, filter, and add the filter residue 8 times the amount of water, boiled for 1 hour, and filtered; add 8 times the amount of water to the filter residue, boiled for 1 hour, filtered, the filtrates were combined, and concentrated under reduced pressure at 50 ° C to a clear liquid with a relative density of 1.0 g / ml. paste, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, recover the ethanol from the ...

Embodiment 7

[0127] 1. Formula (weight ratio)

[0128]

[0129] 4. Preparation method

[0130] a. Dissolve hyaluronic acid in 50g of sodium salt solution at 35°C, stir at 1000r / min for 3h, adjust pH to 5.5, add deionized water to 100 and mix evenly to prepare a 5.0% hyaluronic acid solution, store spare;

[0131] b. Take 400 grams of plant conditioner Fructus Cnidii, 400 grams of Gynostemma pentaphyllum, 100 grams of Stephania vine, and 100 grams of sage, mix and grind them into 1000 grams of coarse powder, add 10 times the amount of water, boil for 2 hours, filter, and add the filter residue 8 times the amount of water, boiled for 1 hour, and filtered; add 8 times the amount of water to the filter residue, boiled for 1 hour, filtered, the filtrates were combined, and concentrated under reduced pressure at 50 ° C to a clear liquid with a relative density of 1.0 g / ml. paste, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, recover the ethanol from t...

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Abstract

The invention discloses hyaluronic acid sterilization contraception gel which is characterized by containing the following components in parts by weight: 0.2-5.0% of hyaluronic acid, 5.0-20.0% of a plant regulator, 0.02-0.2% of an external contraception medicine, 1.0-20.0% of a moistening agent, 0.5-5.0% of a thickening agent and 49.9-93.28% of a filling agent. The hyaluronic acid sterilization contraception gel disclosed by the invention contains the hyaluronic acid, the plant regulator and the external contraception medicine, has the effects of sterilization and contraception, is further capable of effectively nourishing private parts and relieving side effects of similar medicines, and is a novel, efficient and safe external contraception method.

Description

technical field [0001] The invention belongs to the technical field of formulation of pharmaceutical preparations, in particular to a contraceptive gel mainly using hyaluronic acid and a preparation method thereof. Background technique [0002] At present, oral contraceptives and external contraceptives are the main contraceptive methods today. Among them, oral contraceptives have high-efficiency and good contraceptive effects, and are used by many people, but the side effects of oral contraceptives are also very obvious, and there are many contraindications. The most widely used external contraceptives at home and abroad are mainly nonoxynol-9, alkanol ether, menthol ether, etc. Their contraceptive effects have been fully affirmed clinically, and they have played a major role in the world's family planning. role. However, it has been reported that if such drugs are used extensively, for a long time and in large quantities, at the usual concentration of vaginal contracepti...

Claims

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Application Information

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IPC IPC(8): A61K36/59A61K31/085A61K9/06A61K47/36A61P15/18A61P15/02A61P31/02
CPCA61K9/0034A61K9/06A61K31/085A61K36/234A61K36/424A61K36/537A61K36/59A61K47/36A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 贺晓军侯如标
Owner 海盾医美科技(杭州)有限公司
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