Method for recovering phenylacetic acid from benzylpenicillin potassium lysis solution

A technology of penicillin potassium and lysate, which is applied in chemical instruments and methods, separation/purification of carboxylic acid compounds, preparation of carboxylate, etc. It can solve the problems of difficult viscous liquid, increase the pressure of environmental protection treatment, etc., and achieve high product quality , Realize the effect of resource utilization

Active Publication Date: 2017-11-24
INNER MONGOLIA CHANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using concentrated sulfuric acid to remove impurities and water multi-stage extraction can effectively separate phenylacetic acid from colored impurities, but in the process of separation, viscous liquid that is difficult to handle will be produced, which will increase the pressure of environmental protection treatment

Method used

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  • Method for recovering phenylacetic acid from benzylpenicillin potassium lysis solution
  • Method for recovering phenylacetic acid from benzylpenicillin potassium lysis solution
  • Method for recovering phenylacetic acid from benzylpenicillin potassium lysis solution

Examples

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Effect test

Embodiment 1

[0036] Embodiment 1 of the present invention reclaims the method for phenylacetic acid from penicillin potassium lysate

[0037] (1) Penicillin potassium lysate extraction

[0038] Take 1L of penicillin potassium lysate, measure its phenylacetic acid concentration by HPLC to be 27.69g / L, lower its temperature to 5°C, and add 500mL of organic solvent toluene for extraction to the penicillin potassium lyse, add 30 % hydrochloric acid, adjust the pH of the feed liquid to be 0.92, stir for 5 min, pour the mixed feed liquid into a separatory funnel and let stand for phase separation to obtain 510 mL of organic phase, which is set aside;

[0039] (2) Decolorization

[0040] Add 5.1 g of activated carbon to the organic phase obtained in step (1), stir for 30 min, and filter with suction to obtain the decolorized organic phase for subsequent use;

[0041] (3) Alkalization

[0042] Adding a mass concentration of 7% sodium hydroxide solution to the decolorized organic phase obtained ...

Embodiment 2

[0053] Embodiment 2 of the present invention reclaims the method for phenylacetic acid from penicillin potassium lysate

[0054] (1) Penicillin potassium lysate extraction

[0055] Get 1L penicillin potassium lysate, measure its phenylacetic acid concentration with HPLC to be 27.69g / L, its temperature is down to 15 ℃, under stirring, add 500mL extraction organic solvent dichloromethane in this penicillin potassium lyse, Add 30% hydrochloric acid, adjust the pH of the feed solution to 0.8, stir for 10 minutes, pour the mixed feed solution into a separatory funnel and let it stand for phase separation to obtain 510 mL of organic phase, which is set aside;

[0056] (2) Decolorization

[0057] Add 5.1 g of activated carbon to the organic phase obtained in step (1), stir for 60 min, and filter with suction to obtain the decolorized organic phase, which is set aside;

[0058] (3) Alkalization

[0059] In the organic phase after the decolorization of step (2) gained, add the sodiu...

Embodiment 3

[0070] Embodiment 3 The method of reclaiming phenylacetic acid from penicillin potassium lysate according to the present invention

[0071] (1) Penicillin potassium lysate extraction

[0072] Take 1L of penicillin potassium lysate, measure its phenylacetic acid concentration by HPLC to be 27.69g / L, lower its temperature to 15°C, add 500mL of organic solvent MIBK for extraction to the penicillin potassium lyse, add 20 % hydrochloric acid, adjust the pH of the feed liquid to be 1.5, stir for 10 min, pour the mixed feed liquid into a separatory funnel and let stand for phase separation to obtain 515 mL of organic phase, which is set aside;

[0073] (2) Decolorization

[0074] Add 5.15g gac to the organic phase obtained in step (1), stir for 30min, and suction filter to obtain the decolorized organic phase, which is set aside;

[0075] (3) Alkalization

[0076] In the organic phase after the decolorization of step (2) gained, add the sodium hydroxide solution that mass concentr...

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Abstract

The invention relates to a method for recovering phenylacetic acid from a benzylpenicillin potassium lysis solution and belongs to the technical field of pharmacy. The method for recovering the phenylacetic acid from the benzylpenicillin potassium lysis solution comprises the steps that the benzylpenicillin potassium lysis solution is extracted through an organic solvent; an organic phase is decolored through an activated carbon and alkalized through a sodium hydroxide solution; and the obtained alkalized water phase is oxidized with hydrogen peroxide and decolored with activated carbon so that a sodium phenylacetate aqueous solution with a light color can be obtained, the sodium phenylacetate aqueous solution is acidized and crystallized through concentrated sulfuric acid, washed with cold water and dried, and phenylacetic acid is obtained. The obtained phenylacetic acid product is high in quality, no waste difficult to deal with is generated in the recovering process, and the method is suitable for large-scale application.

Description

technical field [0001] The invention relates to a method for recovering phenylacetic acid, in particular to a method for recovering phenylacetic acid from a penicillin potassium lysate, and belongs to the technical field of pharmacy. Background technique [0002] Penicillin potassium is cleaved into 6-APA and phenylacetic acid under the action of penicillin G acylase. Phenylacetic acid is a by-product in the production of 6-APA and a precursor in the fermentation of penicillin. How to effectively recover the phenylacetic acid produced during the production of 6-APA and apply it to the fermentation of penicillin is a problem faced by penicillin production enterprises. A lot of research has been done in China on the recovery of phenylacetic acid from 6-APA production wastewater. There are three main recovery processes, which will be described below through specific literature. [0003] Chinese patent (Application No.: 201010519414.7) reports that phenylacetic acid wastewater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/02C07C57/32
CPCC07C51/02C07C51/412C07C51/42C07C57/32
Inventor 陈英新眭谦陈顺记郭建王继明韩贺东
Owner INNER MONGOLIA CHANGSHENG PHARMA
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