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Method for extracting and purifying cannabidiol from China-hemp

A technology of cannabidiol and hemp, which is applied in the field of plant component extraction and purification, can solve the problems of damaging the environment, affecting product safety, and low extraction yield of cannabidiol, so as to improve the extraction rate, reduce the cost of separation and purification, and purify short time effect

Active Publication Date: 2017-11-10
DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2) In the existing cannabidiol extraction and purification process, a large amount of organic solvents, such as n-hexane, dichloromethane, chloroform, methanol, etc., are used. The use of organic solvents will not only damage the environment and affect the safety of the product; The extraction yield of cannabidiol is not high

Method used

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  • Method for extracting and purifying cannabidiol from China-hemp
  • Method for extracting and purifying cannabidiol from China-hemp
  • Method for extracting and purifying cannabidiol from China-hemp

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1: In this embodiment, the steps of extracting and purifying cannabidiol from hemp are as follows:

[0033] Step 1: Harvest hemp flowers and leaves at the mature stage, dry the hemp flowers and leaves at 40° C. for 3 hours to make the water content less than 5%, and crush the hemp flowers and leaves after removing the moisture for use.

[0034] Step 2: Put 100g of crushed hemp flower leaves into a 1L extraction kettle for extraction, supercritical CO 2 The fluid extraction operation process is liquid CO 2 →High pressure pump→extraction kettle (entering supercritical state)→separation kettle Ⅰ→separation kettle Ⅱ→circulation. CO during extraction 2 The fluid flow rate is 20L / h, the temperature of the extraction kettle is 45°C, the extraction pressure is 30MPa, the pressure of the separation kettle Ⅰ and the separation kettle Ⅱ are both 6MPa, and the separation temperature is room temperature. During the extraction process, absolute ethanol is used as the ent...

Embodiment 2

[0048] Example 2: In this example, the steps of extracting and purifying cannabidiol from hemp are as follows:

[0049] Step 1: Harvest hemp flowers and leaves at the mature stage, dry the hemp flowers and leaves at 50° C. for 2 hours to make the water content less than 5%, and crush the hemp flowers and leaves after removing the moisture for use.

[0050] Step 2: Put 100g of crushed hemp flower leaves into a 1L extraction kettle for extraction. During the extraction process, CO 2 The fluid flow rate is 20L / h, the temperature of the extraction kettle is 45°C, the extraction pressure is 30MPa, the pressure of the separation kettle Ⅰ and the separation kettle Ⅱ are both 6MPa, and the separation temperature is room temperature. During the extraction process, absolute ethanol is used as the entrainer. The amount of water and ethanol is 500mL, and the extraction time is 3h to obtain cannabidiol extract.

[0051] Dissolving the cannabidiol extract in absolute ethanol to obtain a ca...

Embodiment 3

[0055] Embodiment 3: The steps of the method for extracting and purifying cannabidiol from hemp in this embodiment are as follows:

[0056] Step 1: Harvest hemp flowers and leaves at the mature stage, dry the hemp flowers and leaves at 30° C. for 4 hours to make the water content less than 5%, and crush the hemp flowers and leaves after removing the moisture for use.

[0057] Step 2: Put 100g of crushed hemp flower leaves into a 1L extraction kettle for extraction. During the extraction process, CO 2 The fluid flow rate is 20L / h, the temperature of the extraction kettle is 45°C, the extraction pressure is 30MPa, the pressure of the separation kettle Ⅰ and the separation kettle Ⅱ are both 6MPa, and the separation temperature is room temperature. During the extraction process, absolute ethanol is used as the entrainer. The amount of water and ethanol is 500mL, and the extraction time is 3h to obtain cannabidiol extract.

[0058] Dissolving the cannabidiol extract in absolute et...

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Abstract

The invention belongs to the technical field of extraction and purification of plant ingredients and particularly relates to a method for extracting and purifying cannabidiol from China-hemp. In the method, an ingredient of cannabidiol is extracted from floral leaves in a mature period of the China-hemp according to a supercritical CO2 extraction technique, a cannabidiol extract is further purified by macroporous adsorbent resin and a rapid purification system, a cannabidiol content of an obtained product is 98% or higher, and the cannabidiol product does not contain a psychotoxic ingredient tetrahydrocannabinol. According to the method, a chemical organic solvent is not used in an extraction process, so that the method is environment-friendly and is low in toxicity and high in efficiency; the loss of cannabidiol in an adsorption elution process is reduced in a purification process, so that the impurity ingredients such as tetrahydrocannabinol and the like are effectively removed, and the use of an organic regent is decreased, so that the purification cost is lowered, and the environmental pollution is reduced. The product is high in yield and purity, and the requirement for development of a value-added product of the China-hemp, in particular to the market requirement of the active ingredient of the cannabidiol product in the China-hemp, can be met, and especially, the cannabidiol product has the great application advantage in the pharmaceutical field.

Description

technical field [0001] The invention belongs to the technical field of extracting and purifying plant components, and in particular relates to a method for extracting and purifying cannabidiol from hemp. Background technique [0002] Hemp belongs to Magnoliopsida, Urticales, Cannabinaceae, Cannabis, Cannabis sativa L., an annual herb. The active components of the hemp plant include cannabinoids and non-cannabinoids, among which the number and active components of the cannabinoids are more. Cannabinoids mainly include Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN) and Cannabigerol (CBG). [0003] The hemp plant is very versatile and can be used in textiles, papermaking, rope making and other fields. In particular, studies in recent years have shown that hemp also has extremely good medicinal value, and cannabinoid compounds are the material basis for its medicinal effects, and are unique active ingredients in hemp plants. Among them, cannabidiol (CBD) and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/70C07C37/72C07C37/82C07C39/23
CPCC07C37/685C07C37/70C07C37/72C07C37/82C07C39/23Y02P20/54
Inventor 高宝昌孙宇峰赫大新石雨张旭田媛崔宝玉
Owner DAQING BRANCH OF HEILONGJIANG ACAD OF SCI
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