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A kind of timolol maleate medicinal composition and preparation method thereof

A technology of timolol maleate and composition, applied in the field of timolol maleate medicinal composition and preparation thereof, can solve the problems of cardiotoxicity, side effects, unfavorable use by infants and young children, decreased effect and the like

Active Publication Date: 2018-05-15
SHANGHAI AUSON PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral timolol has potential cardiotoxic side effects and adverse reactions, and the compliance of patients with young infantile hemangiomas is not good
Eye drops and eye drops are inconvenient for skin application due to their fluidity, and the effect will be reduced, and the application of eye drops can easily cause a decrease in intraocular pressure
[0006] Chinese patents CN201510497475.0 and CN201610297190.7 disclose the prescription and preparation method of timolol maleate gel, but the preparations contain percutaneous penetration enhancers, which will cause excessive blood drug concentration and cause systemic adverse effects reaction, not conducive to use in infants and young children
Chinese patents CN201610427628.9 and CN201610701993.4 conducted experiments on mice and observed clinical effects on children respectively, but lacked specific pharmacokinetic data and no clear guiding significance for clinical medication

Method used

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  • A kind of timolol maleate medicinal composition and preparation method thereof
  • A kind of timolol maleate medicinal composition and preparation method thereof
  • A kind of timolol maleate medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Prescription 1

[0076]

[0077] For the preparation method, refer to the preparation method in the summary of the invention. The value of n is 1.

Embodiment 2

[0079] Prescription 2

[0080]

[0081]

[0082] For the preparation method, refer to the preparation method in the summary of the invention. The value of n is 1.

Embodiment 3

[0084] Prescription 3

[0085]

[0086] For the preparation method, refer to the preparation method in the summary of the invention. The value of n is 1.

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PUM

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Abstract

The invention belongs to the field of preparations and relates to a timolol maleate pharmaceutical composition and a preparation method thereof. The timolol maleate pharmaceutical composition contains timolol maleate, Carbopol, triethanolamine, propylene glycol, ethylparaben and water. The pharmaceutical composition has the advantages of good biocompatibility, easiness in coating, no greasiness and the like, and the use compliance of a patient is greatly improved; the timolol maleate pharmaceutical composition can directly act on a focus of infection, and the local drug concentration is increased, so that the drug effect is furthest exerted, and the untoward effect of the whole body caused due to oral medication or intravenous medication is avoided; and the pharmaceutical composition is suitable for industrial large-scale production, is used for treating hemangioma and is particularly suitable for treating superficial type infantile hemangioma.

Description

technical field [0001] The invention belongs to the field of preparations, and in particular relates to a timolol maleate medicinal composition and a preparation method thereof. technical background [0002] Infantile hemangiomas (IH) are a common benign proliferative tumor of vascular endothelial cells. It mainly occurs in the head and neck of infants and young children, and the location is relatively superficial. The incidence rate in newborns in my country is 2.5% to 12%. Due to the special location of the lesion, it often involves important organs. In severe cases, it can endanger the lives of patients. The family members have brought enormous physical pain and mental pressure. [0003] There are many ways to treat hemangioma, traditionally systemic drug therapy is the first choice. Corticosteroids, interferon, and vincristine have all been used in the treatment of infantile hemangioma, but these drugs have complications of varying degrees, which limit their clinical ap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/5377A61K47/32A61K47/10A61P35/00
CPCA61K9/06A61K31/5377A61K47/10A61K47/32
Inventor 卢恩先李守峰马红岩李朋朋
Owner SHANGHAI AUSON PHARM CO LTD
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