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A core-shell molecularly imprinted polymer capable of identifying erythrosine and its preparation method

A technology of molecular imprinting and polymers, applied in separation methods, alkali metal compounds, chemical instruments and methods, etc., to achieve the effects of overcoming slow kinetics, overcoming mass transfer, and fast and accurate specific recognition

Inactive Publication Date: 2019-04-05
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the advantages and characteristics of molecularly imprinted polymers, if it is used as an adsorbent in the detection of erythrosin, the recovery rate of erythrosine will be greatly improved, and there is no information about erythrosine molecularly imprinted polymers. Related articles of research significance

Method used

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  • A core-shell molecularly imprinted polymer capable of identifying erythrosine and its preparation method
  • A core-shell molecularly imprinted polymer capable of identifying erythrosine and its preparation method
  • A core-shell molecularly imprinted polymer capable of identifying erythrosine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] Example 1: Amination modification of silica surface

[0028] Accurately weigh 1g of solid sodium hydroxide, add 100mL of ultrapure water to dissolve it, and configure it into a sodium hydroxide aqueous solution with a concentration of 0.25 moL / L; accurately measure 6.18mL of hydrochloric acid, add 93.82mL of ultrapure water to dilute, and configure it to a concentration of 2moL / L of hydrochloric acid aqueous solution.

[0029] (1) Activation of silica: accurately weigh 10g of silica microspheres into a 250mL round-bottomed flask, add 100mL NaOH (0.25 moL / L), place it on a magnetic stirrer and stir at room temperature for 30 min. It was eluted with ultrapure water; the alkali-treated silica was then refluxed with 100 mL of 2 moL / L Hcl at 90°C for 8 h. After the reflux, it was eluted with ultrapure water to neutrality and dried.

[0030] (2) Aminated silica surface: Weigh 10 g of activated silica into a 250 mL round bottom flask, add 100 mL of toluene, and then add 5 mL of 3-a...

example 2

[0031] Example 2: Preparation of erythrosin molecularly imprinted polymer and non-molecularly imprinted polymer

[0032] Accurately weigh 0.2375mmoL of erythrosine and dissolve it in 50 mL methanol:water=4:1 (v / v), and add functional 4-VP (0.95mmoL) to the solution, stir and incubate for 2 h at room temperature, then Add surface-modified silica (1g), cross-linking agent EGDMA (4.75mmoL), initiator AIBN (0.014 g) in sequence, mix well with ultrasound, then put into a round bottom flask, magnetically stir at room temperature for 10 minutes, and then add to the top Install a three-way glass tube and pass in nitrogen (60min) to remove oxygen.

[0033] Place the airtight container containing the above reaction solution on a magnetic stirrer, adjust the appropriate speed to continue stirring, heat it in an oil bath at 70°C, take it out after reacting for 24 hours, and polymerize the reaction solution to prepare erythrosine molecularly imprinted polymer ( MIP). During the reaction, the t...

example 3

[0035] Example 3: Adsorption kinetics experiment

[0036] Accurately weigh 7.2 mg of erythrosine solid sample, dissolve it in 12 mL of ultrapure water, mix well with ultrasound, and prepare an aqueous solution of erythrosine with a concentration of 600 μg / mL. Take 10 4mL centrifuge tubes and label them with serial numbers, and then weigh 10 mg of the prepared MIP microspheres and NIP microsphere solids and place them in them, 5 tubes for each of the two types of microspheres. Add 1 mL of 600 μg / mL erythrosine aqueous solution to each centrifuge tube, mix with ultrasound, and then stand for adsorption at room temperature. Take samples when the adsorption time is 5, 15, 30, 45, 60 min, centrifuge to take the supernatant, measure its absorbance at 533nm with an ultraviolet-visible spectrophotometer (Uv-vis), and calculate by the formula (1) Its adsorption capacity (Q), observe the change rule of its adsorption capacity with adsorption time.

[0037]

[0038] Among them, Q is the ads...

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Abstract

The invention relates to a core-shell type molecularly imprinted polymer capable of recognizing erythrosine and a preparation method, which belong to the technical field of molecularly imprinted function materials, and concretely relates to a polymer material with a specific recognition function on the artificially synthesized pigment erythrosine prepared based on a molecularly imprinted technology. Amino-modified silicon dioxide is adopted as a core, an erythrosine pigment molecule is adopted as a template, and a layer of imprinted layer is used for coating the surface thereof. The core-shell type molecularly imprinted polymer capable of recognizing the erythrosine and the preparation method provided by the invention have the advantages that imprinted loci are located on the surface of the polymer, the template is easy to elute from the polymer, the defects of dynamics slow and mass transfer during an adsorption / desorption process are overcome, the specific recognition can be quickly and accurately carried out on the erythrosine, the operation step can be simplified, the usage amount of a solvent is reduced, and the recovery rate is improved.

Description

Technical field [0001] The invention belongs to the technical field of molecular imprinting functional materials, and is a polymer material prepared based on molecular imprinting technology that has a specific recognition function for synthetic pigment erythrosine, and can be specifically identified and separated by erythrosine. Background technique [0002] As a synthetic pigment, erythrosin is often used in foods to improve its sensory properties due to its strong coloring power, good stability and low cost. For most synthetic food colorants, it is not a nutrient and cannot be absorbed by the human body, and its preparation often uses benzene and toluene as raw materials, undergoes a series of sulfonation and nitration reactions, and may be mixed during the synthesis process. Heavy metals such as arsenic and lead, if abused, pose a huge threat to consumers' health. my country has clear standards and limits for the use of food colorants. At present, according to the provisions...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/20C08F226/06C08J9/28C08L33/08C08K9/02C08K9/06C08K7/18B01J20/26B01J20/28B01J20/30B01D15/38
CPCB01D15/3852B01J20/268B01J20/28021C08F220/20C08J9/28C08J2333/08C08K7/18C08K9/02C08K9/06C08F226/06C08L33/08
Inventor 谢卫红刘静静张瑞严恒
Owner HUBEI UNIV OF TECH
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