A traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and its preparation method

A composition and arthritic technology are applied in the field of traditional Chinese medicine compositions for preventing and treating rheumatoid arthritis and the field of preparation thereof, which can solve the problems of long treatment time and slow effect, achieve less harsh process conditions, reduce slow absorption and irregularity, The effect of facilitating the promotion of the application

Active Publication Date: 2020-11-24
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional Chinese medicine external preparations for the treatment of RA are ointment and patch at present, the treatment time is long, the effect is slow, and the side effects of allergies and rashes will occur

Method used

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  • A traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and its preparation method
  • A traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and its preparation method
  • A traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Weigh 6 grams of Eucommia ulmoides, 6 grams of Morus vulgaris, 7 grams of Weilingxian, 6 grams of Salvia miltiorrhiza, 5 grams of Earth Dragon, 8 grams of Habitat, 6 grams of Papaya, 6 grams of Snake Snake, 5 grams of Panax notoginseng, 5 grams of Solanum, 5 grams of safflower, 6 grams of white peony, 6 grams of spatholobi, 7 grams of angelica, 3 grams of centipede.

[0052] Step 2. Preparation of alcohol extract

[0053] Add the weighed peony root, Eucommia ulmoides, Weilingxian, Morus sylvestris, Salvia miltiorrhiza, Panax notoginseng, Safflower, and Safflower to 75% ethanol, then reflux and extract 3 times at 90°C to obtain an alcohol extract, and reflux 75% ethanol for 3 times The amount of addition is: the first time is 8 times the total mass of white peony, Eucommia ulmoides, Weilingxian, Morus sylvestris, Salvia miltiorrhiza, Panax notoginseng, Radix sylvestris, and safflower, the second time is 8 times the total mass of the above , The third time is 6 times the sum ...

Embodiment 2

[0061] 1. Investigation of the therapeutic activity of the traditional Chinese medicine composition of the present invention.

[0062] 1) Animal grouping and adjuvant arthritis rat model construction.

[0063] After 2 weeks of adaptive feeding, 10 SD rats were randomly selected as the normal control group, and the rest were used for model building. After fasting for 12 hours, except the normal control group, the rest of the rats were placed in cold water at 4°C-8°C with a water surface height of 2 cm. After 30 minutes, they were taken out. The body of the rat was dried by an electric fan, and the rat’s right hind foot pad Intradermal injection of Freund’s complete adjuvant 0.1 ml / mouse, rats in the normal group were injected with an equal volume of normal saline for 2 consecutive days. On the 9th day after the inflammation, the rats developed secondary arthritis symptoms (non-inflammatory and joint swelling of both forelimbs), listlessness, and loose hair in the left hind foot, in...

Embodiment 3

[0081] Comparison of the therapeutic effects of different dosage forms on cotton ball granuloma in adjuvant arthritis rats.

[0082] The inventor conducted a comparative study on the therapeutic effect of the gel and ointment of the Chinese medicine composition of the present invention on the treatment of adjuvant arthritis rats with cotton ball granuloma.

[0083] The components in Example 1 were pulverized, sieved with 120 mesh, and the fine powder was mixed and added with yellow wine, and stirred into a paste to obtain a paste mixture, wherein each 100 g paste mixture contained 30 g of traditional Chinese medicine composition. The obtained mixture is uniformly smeared on the plaster to obtain the plaster of the present invention.

[0084] 40 rats were randomly divided into normal control group, model control group, Chinese medicine gel group and traditional plaster group. The method of building adjuvant arthritis rat model and the method of administration are the same as above. ...

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 5-7 parts of eucommia ulmoides, 5-7 parts of loranthus parasiticus, 6-8 parts of radix clematidis, 5-7 parts of salviae miltiorrhizae, 4-6 parts of earthworm, 7-9 parts of radix rehmanniae recen, 5-7 parts of pawpaw, 5-7 parts of zaocys dhumnade, 4-6 parts of pseudo-ginseng, 4-6 parts of radix angelicae pubescentis, 4-6 parts of safflower carthamus, 5-7 parts of radix paeoniae alba, 5-7 parts of spatholobus suberctu, 6-8 parts of angelica sinensis and 2.5-3.5 parts of centipedes. The traditional Chinese medicine composition can be used for effectively treating rheumatoid arthritis inshort treatment time. A gel-type preparation prepared from the traditional Chinese medicine composition has a better treatment effect than that of conventional paste and patch, and can act on skin, mucous membranes and tracts, so that first pass elimination caused by oral administration can be avoided, and slow and irregular absorption and other defects and adverse response, such as allergy and rash, generated in the applying process in traditional paste can be relieved. The traditional Chinese medicine composition has the advantages of being convenient and comfortable in use, good in biocompatibility, non-strict in process condition and the like, is suitable for production condition of traditional Chinese medicinal compound preparations, is convenient for popularization and application, and can be used as first choice for improving traditional external preparations of traditional Chinese medicines.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and specifically relates to a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, multi-system, inflammatory autoimmune disease mainly involving peripheral joints. Its clinical manifestations are pain, swelling, and decreased function of the affected joints. The pathology is chronic synovitis, which erodes cartilage and bone and destroys joints. The patient’s muscles, myelin sheaths, and bursae can also be invaded, and multiple organs and systems such as skin, breathing, blood, nerves, kidneys, heart, and eyes can also be affected. The commonly used drugs for treatment are traditionally divided into non-steroidal anti-inflammatory drugs, anti-rheumatic drugs to improve the condition, glucocorticoids, and immunomodulators. [0003] Rheuma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/06A61P19/02A61P29/00A61K35/648A61K35/62A61K35/583
CPCA61K9/0014A61K9/06A61K35/583A61K35/62A61K35/648A61K36/185A61K36/232A61K36/258A61K36/286A61K36/46A61K36/486A61K36/537A61K36/65A61K36/71A61K36/716A61K36/732A61K36/804A61K47/32A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 徐志立袁子民张明波康廷国陶新知王素娟梁晗业
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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