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Medical purpose of phellamurin in amur corktree leaves in lung cancer prevention aspect

A technology of cork leaves and phellodendron, which is applied in the application field of phellodendron in the preparation of anti-lung cancer drugs, and achieves good application prospects and effects of reducing adverse effects

Inactive Publication Date: 2017-09-26
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature disclosing the anti-lung cancer application of Phellodendron

Method used

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  • Medical purpose of phellamurin in amur corktree leaves in lung cancer prevention aspect
  • Medical purpose of phellamurin in amur corktree leaves in lung cancer prevention aspect
  • Medical purpose of phellamurin in amur corktree leaves in lung cancer prevention aspect

Examples

Experimental program
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Embodiment 1

[0041] 1. Cell culture

[0042] A549 cells were cultured in DMEM high-glucose medium containing 10% (v / v) fetal bovine serum at 37°C, 5% CO 2 , cultivated in a saturated humidity incubator. According to different experimental requirements, they were cultured in 96-well plate and 6-well plate respectively.

[0043] 2. Drug Treatment of Cells

[0044] The cells were treated with 250 μM, 1000 μM and 2000 μM Phellodendron for 48 hours for MTT, cell cycle, apoptosis, SOD, MDA, GSH, caspase 3 activity and western blot detection. The cells were treated with 2000μM Phellodendron for 6h, 12h and 24h, respectively, for the detection of mitochondrial membrane potential.

[0045] 3. Related Results

[0046] (1) Phellodendron can inhibit the proliferation of A549 cells.

[0047] MTT colorimetry is a common method for detecting cell viability. Since cell viability is positively correlated with cell number, MTT method is also commonly used to detect cell proliferation. Such as figure...

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Abstract

The invention discloses a medical purpose of phellamurin in amur corktree leaves in an anti-lung-cancer aspect, and particularly relates to application of phellamurin to preparation of anti-lung-cancer medicine, and discloses a novel medical purpose. The reference is provided for the application of the natural product of phellamurin to the anti-lung-cancer field. Good application prospects are realized. Meanwhile, the amur corktree leaves are utilized; the adverse influence of the self allelopathic effect on the environment is also reduced; the positive effect is achieved on protecting the amur corktree populations.

Description

technical field [0001] The invention discloses the medical use of phellodendron in the leaves of Phellodendron amurense for anti-lung cancer, in particular relates to the application of phellodendron in the preparation of anti-lung cancer drugs, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Cancer refers to malignant tumors and is the second leading cause of death in the world. There are many causes of cancer. Years of epidemiological research and experimental and clinical observations have found that environment and behavior have an important impact on the occurrence of human cancer. It is estimated that more than 80% of cancers are related to environmental factors. Various environmental and genetic carcinogens may cause non-lethal DNA damage in a synergistic or sequential manner, thereby activating proto-oncogenes or inactivating tumor suppressor genes, coupled with changes in apoptosis regulatory genes and DNA ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00A61P11/00
CPCA61K31/7048A61K36/756
Inventor 张桂荣郭鹤云刘欢欢
Owner JILIN UNIV
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