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A traditional Chinese medicine composition with anti-lung cancer activity and its preparation method and application

A composition and anti-lung cancer technology are applied in the directions of drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., which can solve the problems of large dosage, many impurity components, slow onset of effect, etc. The ratio is scientific and reasonable, and the effect of fast absorption

Active Publication Date: 2018-04-03
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

However, the current reported antineoplastic drugs have a large dosage, many impurities, and slow onset of action.

Method used

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  • A traditional Chinese medicine composition with anti-lung cancer activity and its preparation method and application
  • A traditional Chinese medicine composition with anti-lung cancer activity and its preparation method and application
  • A traditional Chinese medicine composition with anti-lung cancer activity and its preparation method and application

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preparation example Construction

[0039] 2. the preparation method of the Chinese medicine composition with anti-lung cancer activity of the present invention, it may further comprise the steps:

[0040] (1) Take 20 grams of Hedyotis diffusa, 15 grams of Shanzi mushroom, 15 grams of cat's claw, 10 grams of fried Puhuang by weight, add 75% ethanol of 10 times the volume of the total medicinal material weight, and reflux or continuously reflux Extract 3 times, 2 hours each time, combine the extracts, concentrate under reduced pressure at 50-70 degrees Celsius, and get the concentrate on a macroporous adsorption resin column, first elute with water, and then successively wash with ethanol with a volume concentration of 20%-70%. Take off; collect the ethanol eluate with a combined volume concentration of 60%, and concentrate to obtain the extract;

[0041] (2) Take 12 grams of Adenophora radix and 10 grams of Ophiopogon japonicus in parts by weight, add water 10 times the weight of the total medicinal materials, s...

Embodiment 6

[0077] The clinical trial results of the Chinese medicine composition with anti-lung cancer activity provided by the present invention show that: 40 patients with lung cancer chemotherapy were treated with the Chinese medicine composition with anti-lung cancer activity (Example 1 of the present invention) provided by the present invention. According to clinical observations, the clinical symptoms of tumor patients who took the compound Chinese medicine composition provided by the invention were significantly improved, the quality of life of lung cancer patients was improved, and the toxic and side effects caused by chemotherapy were significantly reduced, indicating that the Chinese medicine provided by the invention has anti-lung cancer activity. The traditional Chinese medicine composition has the effect of protecting and improving the immune function, and has a protective effect on peripheral blood, and the effective rate of clinical observation is 80.2%.

[0078] According ...

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Abstract

The invention discloses a traditional Chinese medicine composition with anti-lung cancer activity, its preparation method and its application. The traditional Chinese medicine compound composition consists of 12-36 parts of Radix Adenophora, 10-30 parts of Ophiopogon japonicus, and 20-60 parts of Hedyotis diffusa. 15-45 parts of Shanzi mushroom, 15-45 parts of cat's claw, and 10-30 parts of fried cattail. Pharmacological experiments and clinical experiments show that the traditional Chinese medicine composition with anti-lung cancer activity provided by the present invention has a scientific and reasonable proportion, has anti-cancer and detoxification effects, reduces phlegm and blood stasis, nourishes qi and nourishes yin, and has strong killing effect on lung cancer cells. It can also promote the production of tumor necrosis factor, improve the immunity of tumor patients, and has high safety and low toxic and side effects. The preparation method provided by the invention has stable quality, high content of extracted active ingredients, strong operability, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine composition with anti-lung cancer activity and its preparation method and application. Background technique [0002] Tumor has become the number one killer threatening human survival in the 21st century, with an average of more than 6 million people dying of various tumor diseases every year. China is one of the countries with high incidence of cancer in the world, and it shows a rapid growth trend every year. [0003] With the increasingly serious environmental pollution, air pollution is an important pollution, and air pollution leads to a high incidence of lung cancer. Clinically, the current drugs for the treatment of tumors including lung cancer are mainly chemical drugs, but due to the high toxicity of chemotherapy drugs, while killing tumor cells, they also non-selectively kill the body's own immune cells such as white blood cells and lympho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P35/00
Inventor 程海波周仲瑛沈卫星李柳孙东东徐长亮谭佳妮沈政洁吴东东
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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