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A kind of calcium phosphate bone cement embedding drug-loaded siliceous body and its preparation method and application

A technology of calcium phosphate bone cement and siliceous body, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of drug release rate reduction, improve injectability, improve biocompatibility, and simple preparation method Effect

Active Publication Date: 2019-12-27
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have demonstrated that as the degree of Si-O-Si condensation increases, the drug release rate decreases

Method used

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  • A kind of calcium phosphate bone cement embedding drug-loaded siliceous body and its preparation method and application
  • A kind of calcium phosphate bone cement embedding drug-loaded siliceous body and its preparation method and application
  • A kind of calcium phosphate bone cement embedding drug-loaded siliceous body and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 1000:1 paclitaxel@silica body to the solution, and then add 0.5% gelatin , and continued to mill in a ball mill for 15 minutes, and obtained a powder after rotary evaporation of the obtained solution. Among them, alpha-tricalcium phosphate: paclitaxel@silica body=1000:1

[0039] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0040] The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 11 min by referring to the standard ASTM C191.

Embodiment 2

[0042] Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 500:1 paclitaxel@silica body to the solution, and then add 0.5% gelatin , and continued to mill in a ball mill for 15 minutes, and obtained a powder after rotary evaporation of the obtained solution. Among them, alpha-tricalcium phosphate: paclitaxel@silica body=500:1

[0043] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0044] The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5g / mL, and the initial setting time was determined to be 15 minutes by referring to the standard ASTM C191.

Embodiment 3

[0046]Disperse alpha-tricalcium phosphate in absolute ethanol to form a 40g / L solution, mix at 400rpm for liquid phase grinding for 4h, then add 200:1 paclitaxel@silica body to the solution, and then add 0.5% gelatin , and continued to mill in a ball mill for 15 minutes, and obtained a powder after rotary evaporation of the obtained solution. Among them, alpha-tricalcium phosphate: paclitaxel@silica body = 200:1

[0047] Take by weighing 0.1g phosphorylated chitosan, 0.15g gelatin, 0.1g hydroxypropyl methylcellulose, dissolve in 19.65g sodium hydrogen phosphate solution, prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose bone cement solidification solution.

[0048] The bone cement powder and curing liquid were mixed at a solid-liquid ratio of 2-2.5 g / mL, and the initial setting time was determined to be 16 min by referring to the standard ASTM C191.

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Abstract

The invention relates to medicine-loaded siliceous body embedded calcium phosphate bone cement and a preparation method and application thereof. The preparation method comprises the following steps: mixing a self-curing component and a heating nanomaterial to obtain modified bone cement solid powder, wherein an alpha-tricalcium phosphate material plays embedding and carrying roles and a paclitaxel@siliceous body plays an anti-cancer role; with sodium phosphate as a main body and phosphorylated chitosan, hydroxypropyl methyl cellulose and gelatin as modifiers, preparing a neutral bone cement curing solution which improves injectability of a formula; mixing the bone cement solid powder and the curing solution, wherein a main component hydroxyapatite of a cured product is added and the paclitaxel@siliceous body has very good degradability in a living body. The preparation method is simple and convenient, used raw materials are simple, and the preparation method is suitable for mass production; the develop medicine-loaded novel formula improves the biocompatibility of the original bone cement; through addition of the paclitaxel@siliceous body with a thermotherapeutic effect, the injectability of the medicine-loaded siliceous body embedded calcium phosphate bone cement is improved.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a drug-loaded siliceous body calcium phosphate bone cement and its preparation method and application. [0002] technical background [0003] Bone tumor is a tumor that occurs in bone or its subsidiary tissues (blood vessels, nerves, bone marrow, etc.), and is a common disease. Like other tissues in the body, its exact cause is unknown. Tumors are divided into benign tumors and malignant tumors. Benign tumors are easy to remove, generally do not metastasize or recur, and only squeeze and block organs and tissues. Malignant tumors destroy the structure and function of tissues and organs, together with necrosis, bleeding and infection, which seriously threaten human life. Bone tumors or tumor-like lesions are mainly surgical curettage or resection. Tumor surgery strives to be thorough to avoid recurrence or malignant transformation. After surgical resecti...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/54A61L27/12A61L27/20A61L27/22
CPCA61L27/12A61L27/20A61L27/222A61L27/50A61L27/54A61L2300/216A61L2300/416A61L2300/604A61L2400/06A61L2430/02C08L5/08C08L1/284
Inventor 何丹农严一楠刘训伟杨迪诚王萍祝闪闪孙钢金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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