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Preparation method of jellyfish protein composite biological glass tissue repair material

A bioglass and tissue repair technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as poor mechanical properties and poor drug adhesion, and achieve the effect of improving mechanical properties, good porosity, and improving medical properties

Inactive Publication Date: 2017-09-15
HEFEI CHUANGWO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in view of the existence of its amorphous silicon skeleton, bioglass still presents an amorphous form, poor mechanical properties, and poor drug adhesion, and its application in biomedical materials remains to be further developed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of jellyfish protein composite biological glass tissue repair material, comprising the following steps:

[0022] Step 1: Clean the umbrella of fresh jellyfish with running water, cut it into pieces, put it into a beaker, add 10 times the volume of 0.1M sodium hydroxide solution, stir for 3 days, and wash until neutral; then add 10 times the volume of 0.5mol / L acetic acid solution, stirred for 2 days, washed until neutral, dissolved the jellyfish in 8 times the volume of 0.5M acetic acid solution, added 1% pepsin by mass percentage, stirred and extracted at 5°C for 3 days, and centrifuged at 10,000rpm ×1h, take out the supernatant, the supernatant is the pepsin solubilized crude collagen solution, add NaCl to the crude solution to a concentration of 0.9M, stir overnight, centrifuge at 10000rpm×15min, take out the precipitate and dissolve it in 6 times the volume 0.5M acetic acid, transferred to a dialysis bag for dialysis for 2 days, centrifuged at ...

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PUM

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Abstract

The invention relates to a preparation method of a jellyfish protein composite biological glass tissue repair material, and belongs to the field of biomedical materials, wherein the preparation method comprises preparing jellyfish protein, preparing a fibroin solution, preparing a biological glass solution, and carrying out electrospinning to prepare the repair material. According to the present invention, the jellyfish protein can improve the arrangement and the distribution of the collagen fibers, the fibroin can improve the mechanical property of the material, and the biological glass can improve the medical property of the material; and the prepared jellyfish protein composite biological glass tissue repair material has advantages of good mechanical property, good tissue repair performance and good drug adhesion.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a method for preparing a jellyfish protein composite biological glass tissue repair material. Background technique [0002] Since the discovery of bioglass, people have paid more attention to the influence of bioglass components on biological activity. The rise of nanotechnology has made people realize that structure also has an important impact on biological activity, and more attention has been paid to the effect of size effect and microscopic fine structure on the structure and performance of materials. The nano-bioglass and mesoporous bioglass developed and designed from the nano-scale have attracted the attention of scholars at home and abroad. Bioglass can activate cell genes, help to enhance cell proliferation and differentiation, and has osteoinductive and osteoconductive effects. However, in view of the existence of its amorphous silicon skeleton, bioglass still pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/54A61L27/58A61L27/50
CPCA61L27/46A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/112A61L2300/252A61L2300/412A61L2300/604A61L2430/02C08L89/00C08L89/06
Inventor 王吉鹏
Owner HEFEI CHUANGWO TECH CO LTD
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