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Liquid metal drug system as well as preparation method and delivery and release method thereof

A liquid metal and drug technology, applied in the directions of drug delivery, drug formulation, drug combination, etc., can solve problems such as large volume, and achieve the effects of delivery and release, simple method, good carrying and protection.

Inactive Publication Date: 2017-09-08
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these stimulation modalities require bulky and specialized external equipment

Method used

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  • Liquid metal drug system as well as preparation method and delivery and release method thereof
  • Liquid metal drug system as well as preparation method and delivery and release method thereof
  • Liquid metal drug system as well as preparation method and delivery and release method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Preparation of Liquid Metal and Drug Substances: Liquid Metal 2 for Gallium Indium Alloy Ga 24.5 In, drug substances include doxorubicin liposomes, doxorubicin-HPMA, doxorubicin pluronic micelles, doxorubicin-HPMA-galactosamine, and the like.

[0040] Its preparation method, refer to figure 1 , including the following steps:

[0041] S1: Take liquid metal 2 - gallium indium alloy Ga 24.5In and doxorubicin liposomes for the treatment of breast cancer, etc., pour 10g of liquid metal 2 and 1g of drug particles 1 into different beakers;

[0042] S2: Use an electromagnetic stirrer to stir the mixed liquid metal and breast cancer drug powder, so that the outer skin of the liquid metal is continuously oxidized and then adheres more breast cancer drug powder. The stirring speed is 350r / min, and the stirring time is 90min , the stirring temperature is 40°C;

[0043] S3: After the stirring is completed, use a straw to transfer the prepared liquid metal coated with the breast ...

Embodiment 2

[0047] A drug delivery and release method in liquid metal for the treatment of liver cancer, referring to figure 2 and image 3 , including the following steps:

[0048] S1: Preparation of drug-coated liquid metal: the liquid metal is pure gallium Ga, and the drug is nano-scale particles for treating liver cancer. Put it in a certain concentration of physiological solution or a solution similar to the composition of human body fluids;

[0049] S2: Take a drop of tiny liquid metal ball coated with liver cancer drugs, put it in Hank’s solution which is similar to the composition of human body fluid, add fixed electrodes at both ends of the solution, and apply 10V voltage at the same time. The drug-coated liquid metal can advance at a certain speed in the solution to achieve liquid metal drug delivery, such as figure 2 As shown, in the blood vessel 4, go forward in the direction of the arrow, and 5 is the red blood cell in the blood;

[0050] S3: Take a drop of tiny liquid ...

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Abstract

The invention provides a liquid metal drug system. The liquid metal drug system comprises liquid metal and drug powder coating the outer surface of a liquid metal droplet. The invention also provides a preparation method of the liquid metal drug system. The preparation method comprises the following steps: adding the liquid metal into a glass breaker, then adding a drug in a corresponding ratio, stirring at a certain rotating speed by adopting a stirrer at a certain temperature, oxidizing the liquid metal in the air so as to form an oxidized film, and coating the drug powder on the oxidized film; putting the liquid metal coated with the drug into a Hank's solution or HCl solution similar to ingredients of a physiological solution and human body fluid, inserting electrodes at the two ends of the solution, and introducing a certain voltage, so that the liquid metal micro droplet coated with the drug can freely move forward, and drug delivery of the liquid metal is realized; and when a negative electrode is in contact with the liquid metal coated with the drug and after electrical stimulation is carried out, slowly releasing the drug by the liquid metal. The liquid metal drug system provided by the invention can conveniently, rapidly and efficiently realize loading, delivery and release of the liquid metal drug.

Description

technical field [0001] The invention belongs to the technical field of drug delivery, in particular to a liquid metal drug system and its preparation, delivery and release methods. Background technique [0002] Cancer is the number one disease killer in nature. Chemical drug therapy is an important treatment method, but it will produce various side effects, and has low targeting and low utilization rate. Drug delivery system (DDS) can overcome the shortcomings of the above-mentioned chemical drug treatment, so it has always been the research focus of industry and academia. The development of new technologies for low-cost and high-efficiency drug delivery has great social value and broad market prospects . [0003] There are various material systems for loading drugs. The existing researches include liposomes, polymer micelles, dendrimers, proteins, cells, bacteria, graphene, mesoporous silicon, hydrogels, carbon nanometers, drug Patches, drug delivery chips, and various na...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/02A61P35/00
CPCA61K9/0009A61K9/1676A61K47/02
Inventor 梁书婷刘静
Owner TSINGHUA UNIV
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