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Temperature-sensitive medical chitosan derivative preparation and preparation method thereof

A chitosan derivative and temperature-sensitive technology, applied in the field of medicine and health, can solve the problems of increased burden on doctors and patients, shortened product action time, increased use frequency, etc., and achieves good histocompatibility and good hemostasis. , the effect of reducing the number of uses

Inactive Publication Date: 2017-08-11
惠众国际医疗器械(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the use of chitosan, carboxymethyl chitosan or hyaluronic acid as the main raw material, and the gel products used for the above-mentioned purposes, all of them will flow in human tissues after being applied to the human body, which is not easy to retain, and the resulting The loss or absorption is too fast, which shortens the action time of the product and increases the number of times of use, which increases the burden on doctors and patients

Method used

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  • Temperature-sensitive medical chitosan derivative preparation and preparation method thereof
  • Temperature-sensitive medical chitosan derivative preparation and preparation method thereof
  • Temperature-sensitive medical chitosan derivative preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Step 1: Chitosan product purification

[0037] Weigh a certain amount of chitosan crude product, dissolve it in 1% hydrochloric acid according to the ratio of 1g: 50mL, filter to remove insoluble matter, add dropwise 1mol / L sodium hydroxide solution until it is slightly alkaline, obtain a precipitate, wash with purified water To neutrality, use ethanol solution to desalt and dehydrate, and obtain purified chitosan after drying.

[0038] Step 2: Preparation of hydroxybutyl chitosan

[0039] Disperse the purified chitosan powder in the ratio of 1g: 10mL in 50% aqueous sodium hydroxide solution for alkalization treatment, and heat treatment for 24 hours under nitrogen protection at a temperature of 50°C. Filter off excess lye, disperse the remaining solids in the aqueous solution of isopropanol at a ratio of 1g: 20mL, then add 1,2-epoxybutylene at a ratio of chitosan 1g: 20mL, react for 1 hour, and Heat at 70°C for 18 hours. After cooling, adjust the pH value to neutral...

Embodiment 2

[0049]Step 1: Chitosan product purification

[0050] Same as Step 1 in Example 1.

[0051] Step 2: Preparation of hydroxybutyl chitosan

[0052] Disperse the purified chitosan powder in the ratio of 1 g: 10 mL in 50% potassium hydroxide aqueous solution for alkalization treatment, and heat treatment for 24 hours under nitrogen protection at a temperature of 40° C. Filter off the excess lye, disperse the remaining solids into isopropanol aqueous solution at a ratio of 1g:20mL, then add a certain volume of 1,2-epoxybutane, react for 1 hour, and heat at 60°C for 24 hours. After cooling, adjust the pH value to neutral, filter out the insoluble matter, add ethanol, centrifuge and dry to obtain the hydroxybutyl chitosan product.

[0053] Step 3: Preparation of hydroxybutyl chitosan solution

[0054] Under aseptic processing conditions, the content of hydroxybutyl chitosan is 30.0 mg / mL, the content of sodium chloride is 7.0 mg / mL, the content of disodium hydrogen phosphate is 2.0...

Embodiment 3

[0063] Step 1: Chitosan product purification

[0064] Same as Step 1 in Example 1.

[0065] Step 2: Preparation of hydroxybutyl chitosan

[0066] Disperse the purified chitosan powder in the ratio of 1g: 10mL in 50% aqueous sodium hydroxide solution for alkalization treatment, and heat treatment for 24 hours under nitrogen protection at a temperature of 50°C. Filter off excess lye, disperse the remaining solids in the aqueous solution of isopropanol at a ratio of 1g: 20mL, then add 1,2-epoxybutylene at a ratio of chitosan 1g: 20mL, react for 1 hour, and Heat at 55°C for 24 hours. After cooling, adjust the pH value to neutral, filter out the insoluble matter, add ethanol, centrifuge and dry to obtain the hydroxybutyl chitosan product.

[0067] Step 3: Preparation of hydroxybutyl chitosan solution

[0068] Under aseptic processing conditions, the content of hydroxybutyl chitosan is 25.0mg / mL, the content of sodium chloride is 8.0mg / mL, the content of disodium hydrogen phosph...

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Abstract

The invention belongs to the technical field of medicine and hygiene, and in particular relates to a temperature-sensitive medical chitosan derivative preparation and a preparation method of the temperature-sensitive medical chitosan derivative preparation. The main ingredient, namely, chitosan derivative in the preparation is hydroxybutyl chitosan. The product has the temperature sensitivity, and has good effects of bleeding stopping, adhesion preventing, drug sustained release, and prevention and treatment for osteoarthritis. The preparation method of the temperature-sensitive medical chitosan derivative preparation has the advantages that large-scale production can be realized, high-pressure steam sterilization or filtration sterilization can be realized, and viruses, immunogenicity and the like can be removed.

Description

technical field [0001] The invention belongs to the technical field of medicine and sanitation, and specifically relates to a temperature-sensitive medical chitosan derivative preparation and a preparation method thereof. The chitosan derivative in the preparation is mainly composed of hydroxybutyl chitosan. Background technique [0002] Chitosan is the only multifunctional cationic electrolyte existing in nature. Chitosan has excellent properties such as good biocompatibility, biodegradability, low toxicity, biosorption, antibacterial, antitumor activity, etc., so it has been widely used in biomedicine, tissue engineering, drug controlled release, Agriculture, food, water treatment and paper making and other fields. However, the hydrogen bonds between chitosan molecules are relatively strong, so that there is a compact crystallization region in the polymer, which is insoluble in common solvents and can only be dissolved in some acidic media. High crystallinity, poor solub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L31/04A61L31/02A61L31/14A61L31/16A61K47/36
CPCA61K47/36A61L26/0004A61L26/0023A61L26/0061A61L26/0066A61L31/028A61L31/042A61L31/14A61L31/16A61L2300/232A61L2300/41A61L2300/412A61L2300/424A61L2400/04C08L5/08
Inventor 孙陆军郭文广闫瑞国潘海江
Owner 惠众国际医疗器械(北京)有限公司
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