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Metal salt compositions

A composition and technology of oral care, applied in drug combinations, antibacterial drugs, dentistry, etc., can solve the problems of untaught net zinc and net citrate

Active Publication Date: 2017-08-01
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this reference does not teach a specific ratio of net zinc to net citrate, a specific pH, or a combination of zinc chloride and zinc citrate

Method used

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  • Metal salt compositions
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Experimental program
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Effect test

Embodiment 1

[0086] Table 1 provides a comparison of two exemplary formulations of the invention. Soluble zinc analysis was performed as described below, and the results showed that Formulation A (pH 5.9) had a significantly higher soluble zinc content than Formulation B (pH 6.7).

[0087] Table 1

[0088]

Embodiment 2

[0090] The soluble zinc concentration of various zinc-citrate formulations was evaluated as follows. A 0.906% w / v sodium chloride solution was prepared in distilled water. Seven test samples were prepared by combining zinc oxide and zinc citrate trihydrate in a sodium chloride solution in specific ratios to achieve a zinc to citrate molar ratio of 10:1 to 1.5:1. All samples were adjusted to have a neat zinc concentration of 0.5% w / w. The samples were stirred for 2-5 days. After centrifugation, the supernatants were analyzed for soluble zinc.

[0091] The results are shown in the table below. A 2:1 ratio of zinc to citrate has been shown to produce the highest concentration of soluble zinc.

[0092] Table 2

[0093]

Embodiment 3

[0095] Zinc uptake in skin in vitro was evaluated using the following test procedure. In vitro skin (IMS Inc., Portland, ME) was cut into uniform circles between 10 and 14 mm in diameter, such as by using a cork punch. The in vitro skin circles were rinsed (entirely) 3 times with hexane for 5 minutes. Air dry to evaporate hexane. In vitro skin was soaked overnight in sterile and clarified saliva in disposable polystyrene Falcon tubes (manufacturing code 352057). 1 mL of saliva per tissue was used and the process was performed in triplicate. Saliva was aspirated and 1 mL of the 1 :2 paste slurry was added and incubated in a 37°C water bath for 2 minutes. The slurry was aspirated and rinsed 3 times with 5 mL of deionized water for 10 seconds each, using a vortexer to mix. Transfer the tissue into new polystyrene Falcon tubes (manufacturing code 352095). 1 mL of concentrated nitric acid was added to the tissue and it was incubated overnight. Tissue should dissolve completel...

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Abstract

The disclosure provides oral care compositions comprising zinc ions and citrate ions with molar ratios which unexpectedly high zinc bioavailability, together with methods of preparing and using the same.

Description

[0001] Cross references to related patent applications [0002] This application claims the benefit of priority to US Provisional Patent Application No. 62 / 092,509, filed December 16, 2014, which is hereby incorporated by reference in its entirety. Background technique [0003] The amount of a given metal salt that can be incorporated into oral care products is limited due to undesired effects on the user's sensory experience (eg, astringency, taste and mouthfeel). Zinc is a particularly difficult metal ion to incorporate into oral care compositions because the concentration at which it is effective as an antimicrobial agent is very close to the concentration at which it has an unacceptably astringent taste. [0004] These limitations on metal salt concentrations make it difficult to deliver effective amounts of metal ions to the soft and / or hard tissues of the oral cavity using oral care compositions. Embodiments of the present invention provide compositions that, inter alia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61K8/27A61Q11/00A61P1/02
CPCA61K8/27A61K8/365A61Q11/00A61K8/20A61P1/02A61P31/04A61K8/362A61K2800/92
Inventor 斯坦尼斯拉夫·亚拉茨哈什·M·特里维迪林赛·谢弗-科尔贝洛
Owner COLGATE PALMOLIVE CO
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