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Preparation method and application of antiviral extract of yin-nourishing Yinqiao (honeysuckle flower and fructus forsythiae) decoction prescription

A technology of Yinqiao decoction and its extract, which is applied in the field of preparation of Yinqiao decoction traditional Chinese medicine extract, can solve the problems of taking, inconvenient to carry, unsuitable for processing, large dosage, etc., and achieve reduced and stable hygroscopicity Increased performance and large adsorption capacity

Inactive Publication Date: 2017-07-25
江苏海王健康生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Traditionally, the preparation process and taking method of this prescription are mainly water decoction: and the traditional water extraction process has no parameters, so it can be seen that the traditional process is rough, and it is inconvenient to take and carry, and the dosage is large, and it is not suitable for processing into Other dosage forms

Method used

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  • Preparation method and application of antiviral extract of yin-nourishing Yinqiao (honeysuckle flower and fructus forsythiae) decoction prescription
  • Preparation method and application of antiviral extract of yin-nourishing Yinqiao (honeysuckle flower and fructus forsythiae) decoction prescription

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Example 1 Preparation of Traditional Chinese Medicine Extract of "Yinqiao Decoction" by Water Extraction Method

[0038] Method 1: Take honeysuckle, forsythia, bamboo leaves, raw licorice, Ophiopogon japonicus, and rehmannia glutinosa as raw materials, and extract the raw materials with water as a solvent. The weight ratio of each raw material is honeysuckle: forsythia: bamboo leaves: raw Licorice: Ophiopogon japonicus: Rehmannia glutinosa (Xishengdi) = 5:3:2:1:4:4; select the above-mentioned medicinal materials, and weigh 50 kg honeysuckle, 30 kg forsythia and 20 kg bamboo leaves. 10 kg of raw licorice, 40 kg of Ophiopogon japonicus, 40 kg of rehmannia glutinosa, 1.9 tons of water, soaked for 20 minutes, heated and extracted 3 times (the first time is 1 hour, the second time is 45 minutes, and the third time is 30 minutes, each extraction time starts after boiling Calculate), combine the extracts, concentrate the obtained extracts until the volume of the extracts is 3 tim...

Embodiment 2

[0041] Example 2 Preparation of Traditional Chinese Medicine Extract of "Yinqiao Decoction" by Alcohol Extraction Method

[0042] Method 1: Take honeysuckle, forsythia, bamboo leaves, raw licorice, Ophiopogon japonicus, and rehmannia glutinosa as raw materials, and extract the raw materials with 65% ethanol as a solvent. The weight ratio of each raw material is honeysuckle: forsythia: bamboo leaves : Raw licorice: Ophiopogon japonicus: Rehmannia glutinosa (Xishengdi) = 5:3:2:1:4:4; the above-mentioned medicinal materials are cleanly selected, and 50 kg of honeysuckle, 30 kg of forsythia and 20 of bamboo leaves are weighed in proportion. Kg, 10 kg of raw licorice, 40 kg of Ophiopogon japonicus, 40 kg of rehmannia glutinosa, 1.9 tons of 65% ethanol soaked for 20 minutes, heated and refluxed for extraction 2 times, 1 hour each time (the reflux extraction time for each time starts after boiling), extract Combine, stand for 24 hours, filter to take the supernatant, concentrate the sup...

Embodiment 3

[0045] Example 3 Preparation of Traditional Chinese Medicine Extract of "Yinqiao Decoction" by Water Extraction and Alcohol Precipitation

[0046] Method 1: Take honeysuckle, forsythia, bamboo leaves, raw licorice, Ophiopogon japonicus, and rehmannia glutinosa as raw materials, and extract the raw materials with water as a solvent. The weight ratio of each raw material is honeysuckle: forsythia: bamboo leaves: raw Licorice: Ophiopogon japonicus: Rehmannia glutinosa (Xishengdi) = 5:3:2:1:4:4; select the above-mentioned medicinal materials, and weigh 50 kg honeysuckle, 30 kg forsythia and 20 kg bamboo leaves. 10 kilograms of raw licorice, 40 kilograms of Ophiopogon japonicus, 40 kilograms of rehmannia glutinosa, add 1.9 tons: ton of water soaked for 20 minutes, heated and extracted 3 times (the first time is 1 hour, the second time is 45 minutes, and the third time is 30 minutes. The extraction time is from Start the calculation after boiling), combine the extracts, concentrate the...

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Abstract

The invention provides a preparation method and an application of an antiviral traditional Chinese medicine extract of a Yinqiao (honeysuckle flower and fructus forsythiae) decoction prescription. According to the invention, five preparation methods are provided, namely 1) a water extraction method, 2) an alcohol extraction method, 3) a water extraction and alcohol precipitation method, 4) a method combining water extraction and macroporous resin purification, and 5) a method combining alcohol extraction and macroporous resin purification. The invention is derived from a classic ancient prescription, namely 'Yinqiao Decoction' prescription prescribed within Chapter Middle-jiao of No.2 Volume in Differentiation on Febrile Diseases of WU Jutong who is a great master of febrile diseases in Qing dynasty; on the basis of the prescription, process optimization is conducted on the extract, various traditional Chinese medicinal preparations are prepared and major ingredients of active parts are defined. The traditional Chinese medicine extract of the Yinqiao decoction provided by the invention is in the form of an oral preparation. The prepared product (the traditional Chinese medicine extract) is detected, and a conclusion that the traditional Chinese medicine extract of the Yinqiao decoction is high in content of active ingredients is obtained.

Description

Technical field [0001] The invention relates to a preparation method and application of a traditional Chinese medicine extract of Yinqiao Decoction, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Influenza virus, referred to as influenza virus, is an RNA virus that causes influenza in humans and animals. In terms of taxonomy, influenza virus belongs to the Orthomyxoviridae family. It causes acute upper respiratory tract infections and is quickly moved by air. The spread of, there are often periodic pandemics around the world. Influenza virus can cause severe symptoms such as pneumonia or heart and lung failure in elderly or children with weakened immune system and some patients with immune disorders. Traditional Chinese medicine has significant advantages in the treatment of influenza. From the extensive screening of modern pharmacology of traditional prescriptions, Yinqiao Decoction has a significant anti-influenza effect. [00...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P31/16A61P29/00
Inventor 严启新曾琪吕杰刘丹刘霞刘程程蔡凡
Owner 江苏海王健康生物科技有限公司
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