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Preparation method and application of 'baicalin-berberine' compound

A technology of berberine and baicalin, which is applied in the field of preparation of "baicalin-berberine" complex, which can solve the problems of strong stimulation, berberine toxicity, limiting the development and clinical application of berberine oral preparations, etc. Achieve rapid onset, excellent release in vitro, and good anti-inflammatory activity

Inactive Publication Date: 2017-07-21
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Berberine has a toxic and strongly irritating bitter taste, which severely limits the development and clinical application of berberine oral preparations

Method used

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  • Preparation method and application of 'baicalin-berberine' compound
  • Preparation method and application of 'baicalin-berberine' compound
  • Preparation method and application of 'baicalin-berberine' compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take 0.5 g of baicalin and 0.25 g of berberine, disperse them with distilled water (6 mL) respectively, put them into dialysis bags (MW, 8000-14000), place them in a beaker filled with 300 mL of distilled water, seal them, and store them at 80 °C Heating under magnetic stirring for 4 h, letting cool to room temperature, centrifuging (4000 rpm, 10 min), separating the supernatant and the precipitate, adding a small amount of distilled water to wash the precipitate repeatedly 2 to 3 times, and drying to obtain "Baicalin-Berberis base" complex.

[0041] The above-mentioned compound was measured as sample 1, and the specific parameters are shown in Table 1.

Embodiment 2

[0043] Take 0.5 g of baicalin and 0.5 g of berberine, disperse them with distilled water (6 mL) respectively, put them into dialysis bags (MW, 8000~14000), place them in a beaker filled with 300 mL of distilled water, seal them, and store them at 80 °C Heating under magnetic stirring for 4 h, letting cool to room temperature, centrifuging (4000 rpm, 10 min), separating the supernatant and the precipitate, adding a small amount of distilled water to wash the precipitate repeatedly 2 to 3 times, and drying to obtain "Baicalin-Berberis base" complex.

[0044] The above-mentioned compound was measured as sample 2, and the specific parameters are shown in Table 1.

Embodiment 3

[0046] Take 0.5 g of baicalin and 1.0 g of berberine, disperse them with distilled water (6 mL) respectively, put them into dialysis bags (MW, 8000~14000), place them in a beaker filled with 300 mL of distilled water, seal them, and store them at 80 °C Heating under magnetic stirring for 4 h, letting cool to room temperature, centrifuging (4000 rpm, 10 min), separating the supernatant and the precipitate, adding a small amount of distilled water to wash the precipitate repeatedly 2 to 3 times, and drying to obtain "Baicalin-Berberis base" complex.

[0047] The above-mentioned compound was measured as sample 3, and the specific parameters are shown in Table 1.

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Abstract

The invention relates to a preparation method and application of a 'baicalin-berberine' compound. First, baicalin and berberine are prepared into a yellow floccule through a heating method, and the 'baicalin-berberine' compound is obtained through centrifugation and drying. The compound is uniform in color and luster and lower in toxicity. Compared with a crude drug (berberine) and a physical blend, the compound can remarkably mask the bitter taste of the berberine. The better anti-inflammatory activity better than that of the crude drug can be shown in an acute ulcerative colitis (UC) model mouse induced by 4% dextran sodium sulfate (DSS).

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and medicines, and relates to a preparation method and application of a "baicalin-berberine" compound. Background technique [0002] "Scutellaria baicalensis-Huanglian" is a classic medicine pair for clearing away heat and dampness. The two medicines are both bitter and cold medicines. When taken from the Yangming Large Intestine Meridian, they can both clear away heat and dampness, relieve fire and detoxify; the combination of the two medicines can synergistically increase the The effect can make the two play the best curative effect. After the compatibility of the two medicines, it is clinically used for acute enteritis, bacillary dysentery, acute gastritis, chronic atrophic gastritis, toothache, diabetes, etc. The compatibility of Scutellaria baicalensis and Coptis chinensis accounts for a large proportion in traditional Chinese medicine prescriptions. The most prominent co...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/4375A61P29/00
CPCA61K31/4375A61K31/7048A61K2300/00
Inventor 王文苹孙磊雷艳丽隋宏雷亚亚张霞冯军
Owner NINGXIA MEDICAL UNIV
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