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Folate-conjugated-and-targeted nanocomposite particle, and preparation method and application thereof

A technology of nanocomposite particles and coupled folic acid, which can be used in preparations for in vivo experiments, medical preparations with non-active ingredients, wave energy or particle radiation treatment materials, etc., which can solve the side effects of cytotoxicity and cannot completely remove cancer cells To achieve good magnetic response effect, excellent CT imaging effect, and mild reaction conditions

Active Publication Date: 2017-07-21
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing cancer treatment methods mainly include surgery, chemotherapy and radiation therapy, etc., but these methods cannot completely eliminate cancer cells and cause serious side effects on normal tissues and cells of the body

Method used

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  • Folate-conjugated-and-targeted nanocomposite particle, and preparation method and application thereof
  • Folate-conjugated-and-targeted nanocomposite particle, and preparation method and application thereof
  • Folate-conjugated-and-targeted nanocomposite particle, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] In this embodiment PS@CS@Au-Fe 3 o 4 -FA / ICG nanocomposite particles, the nanoparticle with composite structure uses polystyrene as the core, chitosan as the shell, and the outer surface is coated with gold nanoparticles and Fe 3 o 4 The nanoparticles are then grafted with the targeting agent folic acid, and finally loaded with a certain amount of ICG.

[0052] In this embodiment PS@CS@Au-Fe 3 o 4 - The ICG loading rate in the FA / ICG nanocomposite particles is 15%, and the particle size of the nanocomposite particles is 260 nm.

[0053] In this embodiment PS@CS@Au-Fe 3 o 4 -The preparation method of FA / ICG nanocomposite particle comprises the following steps:

[0054] (1) Preparation of polystyrene (PS) microspheres: Take 10 mL and 1 mL of styrene and acrylic acid distilled under reduced pressure and add them to 90 mL of deionized water, place them in a 250 mL three-necked round-bottomed flask, and deoxidize the reactants After treatment, the flask was placed in...

Embodiment 2

[0069] This example is basically the same as Example 1, except that the amount of glutaraldehyde added in this example is 2.0 mL.

Embodiment 3

[0071] This example is basically the same as Example 1, except that the concentration of glutaraldehyde added in this example is 5.0%.

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Abstract

The invention relates to a folate-conjugated-and-targeted nanocomposite particle, and a preparation method and application thereof. The nanocomposite particle uses polystyrene as a core and chitosan as a shell; the external surface of the shell is coated with Au nanoparticles and Fe3O4 nanoparticles, grafted with a targeting reagent folate and loaded with a photo-thermal reagent indocyanine green; and the nanocomposite particle is used as an infrared photo-thermal reagent, a drug carrier, a CT imaging contrast agent, a magnetic resonance imaging contrast agent or a fluorescence imaging contrast agent. Compared with the prior art, the invention has the advantage that the folate-conjugated-and-targeted nanocomposite particle prepared in the invention has good application prospects in CT imaging, magnetic resonance imaging, fluorescence imaging and photo-thermal treatment, can realize targeted delivery of the photo-thermal reagent to a tumor site, effectively kills cancer cells while reducing toxic and side effect on normal tissue and cells, further improves treatment effect and has great potential in promotion of accurate diagnosis and improvement of photo-thermal treatment (PTT) effect on cancers.

Description

technical field [0001] The invention belongs to the technical field of anticancer drug carriers, and relates to a nanocomposite particle coupled with folic acid targeting and a preparation method and application thereof. Background technique [0002] In recent years, affected by environmental pollution and changes in people's lifestyles, cancer cases are increasing year by year, and cancer is increasingly threatening people's health. Existing cancer treatment methods mainly include surgical treatment, chemotherapy and radiotherapy, etc., but these methods cannot completely eliminate cancer cells and cause serious toxic side effects to normal tissues and cells of the body. At the same time, photothermal therapy (photothermal therapy) based on nanomaterials and nanotechnology has attracted widespread attention. Photothermal materials can convert near-infrared light into thermal effects, which can improve treatment efficiency without causing side effects, which has given birth ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/32A61K47/36A61K47/02A61K47/22A61K41/00A61K49/00A61K49/18A61K49/04
CPCA61K41/0042A61K41/0052A61K49/0002A61K49/0093A61K49/04A61K49/1887A61K9/5115A61K9/5123A61K9/5138A61K9/5161
Inventor 王烨颖刘锡建陆杰
Owner SHANGHAI UNIV OF ENG SCI
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