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Application of single nucleotide polymorphism rs2305740 in il12rb1 gene in detecting tuberculosis susceptibility

A single nucleotide polymorphism, tuberculosis technology, applied in the field of biomedicine, can solve the problem of unclear risk relationship of tuberculosis

Active Publication Date: 2019-08-23
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Mycobacterium tuberculosis SNP research has made remarkable achievements in methodology and genomics, the relationship between many SNPs and the risk of tuberculosis infection is still poorly understood, especially the relationship between the IL12RB1 gene SNP and the risk of tuberculosis. The relationship is still unclear

Method used

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  • Application of single nucleotide polymorphism rs2305740 in il12rb1 gene in detecting tuberculosis susceptibility
  • Application of single nucleotide polymorphism rs2305740 in il12rb1 gene in detecting tuberculosis susceptibility
  • Application of single nucleotide polymorphism rs2305740 in il12rb1 gene in detecting tuberculosis susceptibility

Examples

Experimental program
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Embodiment 1

[0039] Example 1. Application of IL12RB1 Gene Single Nucleotide Polymorphism rs2305740 in Detection of Tuberculosis Susceptibility

[0040] 1. Patients and groups

[0041] The case-control study involved in the present invention selects 2039 cases of confirmed cases admitted to the No. 309 Hospital of the People's Liberation Army altogether, and is divided into two groups: (1) tuberculosis group: patients who are admitted to the Institute of Tuberculosis of the whole army are clinically treated by imaging studies, experiments 1032 cases of active tuberculosis patients were confirmed by laboratory examination and anti-tuberculosis treatment, including 605 males and 427 females, with an average age of (39.30±19.29) years old. Including pulmonary tuberculosis, tuberculous pleurisy, tuberculous pericarditis, tuberculous meningitis, tuberculous peritonitis, urinary system tuberculosis, bone and joint tuberculosis, lymph node tuberculosis, etc. (2) Non-tuberculosis control group: 1...

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Abstract

The invention discloses application of IL12RB1 gene single nucleotide polymorphism (SNP) rs2305740 in detecting tuberculosis susceptibility. The application provided by the invention is the application of a substance for detecting rs2305740 site in preparing products for evaluation or auxiliary evaluation of the tuberculosis risk of a to-be-tested patient, or in preparing products for diagnosis or auxiliary diagnosis of tuberculosis of a to-be-tested patient. The inventor of the invention finds, through a case-control study in Chinese Han population, a significant relationship between the gene polymorphism of IL12RB1 gene SNP-rs2305740 sites and tuberculosis resistance. The population with IL12RB1-rs2305740GG genotype and GGGAG diplotype has lower risk of tuberculosis in Mycobacterium tuberculosis infection. The invention provides new insight for the association between inflammation and immune related gene SNP and tuberculosis susceptibility, and has a significant value in screening tuberculosis susceptibility genes and preventing tuberculosis.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of IL12RB1 gene single nucleotide polymorphism rs2305740 in the detection of tuberculosis susceptibility, in particular to the application of IL12RB1 gene single nucleotide polymorphism rs2305740 locus marker in crowd susceptibility to tuberculosis Applications in screening and assessment. Background technique [0002] Tuberculosis (Tuberculosis, TB) is a global disease that seriously threatens human health, and it has become one of the three major infectious diseases killers of human beings. The World Health Organization's global tuberculosis report pointed out that about 1 / 3 of the people are infected by Mycobacterium tuberculosis, and only 10% of the infected people get sick. This means that whether tuberculosis infection occurs is closely related to the interaction between host and pathogen, environment, genetics and so on. Recently, many studies have demonstrated th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
Inventor 吴雪琼张俊仙龚文平安慧茹阳幼荣梁艳
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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