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Traditional Chinese medicine prescription for treating viral hepatitis B and preparation method of traditional Chinese medicine prescription

A technology of viral hepatitis and traditional Chinese medicine, applied in the direction of antiviral agents, medical formulas, medical preparations containing active ingredients, etc., can solve the problems of inability to completely remove hepatitis B virus accurately and effectively

Inactive Publication Date: 2017-07-07
姚萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is currently no specific drug that can completely eliminate HBV in clinical practice.

Method used

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  • Traditional Chinese medicine prescription for treating viral hepatitis B and preparation method of traditional Chinese medicine prescription
  • Traditional Chinese medicine prescription for treating viral hepatitis B and preparation method of traditional Chinese medicine prescription
  • Traditional Chinese medicine prescription for treating viral hepatitis B and preparation method of traditional Chinese medicine prescription

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0016] Experimental example 1 Selection of extraction solvent and rough selection of extraction method

[0017] Get the coarse powder 80 grams of Chinese medicine composition, test according to the scheme in table 1, test result is as shown in table 2:

[0018] Table 1 Different extraction schemes

[0019] Option One Decoct and extract twice, each time for 2 hours, the amount of water added is 10 times the amount of medicinal materials each time Option II Reflux extraction 2 times, 2 hours each time, add 5% ethanol to 10 times the amount of medicinal materials third solution Reflux extraction 2 times, 2 hours each time, add 40% ethanol to 10 times the amount of medicinal materials Option four Reflux extraction 2 times, 2 hours each time, add 80% ethanol to 10 times the amount of medicinal materials Option five Reflux extraction 2 times, 2 hours each time, add 95% ethanol to 10 times the amount of medicinal materials Option six ...

experiment example 2

[0023] Experimental Example 2 Investigation on Water Extraction Process of Traditional Chinese Medicine Composition

[0024] 1. The influence of the processing length of medicinal materials on the paste yield

[0025] Weigh 80g of the traditional Chinese medicine composition, soak the medicinal material with 10 times the amount of water for 30 minutes, decoct 2 times for 2 hours each time, filter, combine the filtrates, concentrate, and measure the ointment yield. The results are shown in Table 3:

[0026] Table 3 Effect of processing length of medicinal materials on ointment yield

[0027]

[0028] It can be seen from the above table 3 that the ointment yield of the coarse powder of medicinal materials is the highest, but because the medicinal liquid is difficult to filter after the coarse powder of medicinal materials is extracted, although the medicinal residues can be squeezed out mechanically during the experiment, it is not suitable for large-scale industrial producti...

experiment example 3

[0045] Experimental Example 3 Extraction Scheme Verification

[0046] According to the optimized test conditions, weigh 10,000g of the traditional Chinese medicine composition processed into a 1.0cm section, extract twice, add 8 times the amount of water for 30 minutes, decoct for 2 hours, and add 8 times the amount of water for the second time. Boil for 2 hours, after extraction, filter the extract, concentrate the filtrate, and dry under reduced pressure (temperature is 65-75°C, vacuum degree is 0.08-0.1Mpa) to measure the yield of paste, the results are shown in Table 8:

[0047] Table 8 Extraction scheme verification

[0048] group 1 2 3 average value Extract yield (%) 24.4 24.3 24.4 24.4

[0049] It can be seen from the above table 8 that it is reasonable and feasible to use the optimized test conditions to extract the traditional Chinese medicine composition.

[0050] The specific method for the determination of the cream yield described in ...

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Abstract

The invention discloses a traditional Chinese medicine prescription for treating viral hepatitis B, and belongs to the field of traditional Chinese medicinal preparations. The traditional Chinese medicinal preparation is a pharmaceutical composition of Tibetan capillaris, radices macrotomiae, chicory herb, radix bupleuri, radix gentianae, Japanese wormwood herb and cornu saigae tataricae, and in accordance with a conventional process, the pharmaceutical composition is prepared into any one of the following pharmaceutical dosage forms: tablets, capsules, granules, pills and the like. The traditional Chinese medicinal preparation for treating the viral hepatitis B provided by the invention is scientific and reasonable in compatibility. The traditional Chinese medicinal composition can obviously reduce a DHBV-DNA titer, an HBsAg level and AST and ALT activities in serum of a hepatitis B model duck; within 7 days of drug withdrawal, a recurrence phenomenon is avoided; and in addition, the composition can relieve degeneration of hepatic cells and inflammatory cell infiltration. It is indicated that the composition is obvious in effect of resisting hepatitis B virus of the duck; therefore, it is indicated that the prescription has a clinical application value.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine prescription for treating viral hepatitis B and a preparation method thereof. Background technique [0002] Hepatitis B virus (Hepatitis B virus, HBV) has been plagued by humans worldwide since its discovery in the 1960s. Although many countries have widely implemented immunization programs, according to the report of the World Health Organization (WHO), Of the 6 billion people in the world, 1 / 2 live in areas with high HBV prevalence, about 2 billion people have been proven to be infected with HBV, 300-400 million people are chronically infected with HBV, and 25%-40% of them will eventually die of liver cirrhosis and liver cancer. Among the top 10 causes of death in the world, viral hepatitis B ranks 7th, with approximately 750,000 deaths due to viral hepatitis every year (http: / / www.who.lnt / csr / disease / hepatitis / ). Compa...

Claims

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Application Information

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IPC IPC(8): A61K36/515A61P1/16A61P31/20A61K35/32
CPCA61K9/0053A61K9/08A61K35/32A61K36/233A61K36/28A61K36/282A61K36/30A61K36/51A61K36/515A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 不公告发明人
Owner 姚萍
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