A kind of method that catalyzes hydrocyanic acid and oxirane to synthesize 3-hydroxy propionitrile

Abstract

The complex of boron trifluoride and 1,2-pentanediol immobilized on activated alumina is used to catalyze the reaction of hydrogen cyanide and ethylene oxide to synthesize 3-hydroxypropionitrile. Utilizing this method, there is no need for a large amount of acid to neutralize the reaction mixture during the reaction, and a large amount of inorganic salts are not produced. It is a reaction with 100% atom economy. It has a short reaction route, few operating steps, and easy product separation, making it a simple and easy-to-operate reaction. ; Under low-temperature reaction conditions, there is no risk of large amounts of hydrogen cyanide overflowing in the system, and it is a safe reaction to operate.

Description

technical field [0001] The invention discloses a method for synthesizing 3-hydroxypropionitrile by catalyzing hydrocyanic acid and ethylene oxide, belonging to the field of organic synthesis and organic catalysis. Background technique [0002] Cyclophosphamide is an alkylating agent, mainly used in tumor immunity, and has obvious inhibitory effect on a variety of tumors. There are strong indications for different systemic necrotizing vasculitis, dermatomyositis, polymyositis, and scleroderma, and it is advisable to maintain the drug for a long time even after clinical remission. Clinically used in malignant lymphoma, multiple myeloma, leukemia, breast cancer, ovarian cancer, cervical cancer, prostate cancer, colon cancer, bronchial cancer, lung cancer, etc., has a certain effect. It can also be used in the treatment of rheumatoid arthritis, nephrotic syndrome in children and autoimmune diseases. An important route for the synthesis of cyclophosphamide is to add 3-aminoprop...

AI Technical Summary

Problems solved by technology

[0012] The present invention intends to solve the problem of producing a large amount of inorganic salt waste in the process of synthesizing 3-hydroxypropionitrile from ethylene oxide and hydrocyanic acid;

[0013] The present invention intends to solve the problem that the content of hydrocyanic acid in the environment may exceed the safe range in the process of synthesizing 3-hydroxypropionitrile by reacting ethylene oxide and hydrocyanic acid;

[0014] The present invention intends to solve the problem that the yield of hydrocyanic acid and oxirane is not high in the reaction of 3-hydroxypropionitrile at room temperature