Application of galanin to preparation of reagent for preventing cerebral ischemic stroke

A technology of ischemic stroke and galanin, which is applied in the field of medicine and can solve the problems of lack of systematic research

Inactive Publication Date: 2017-06-23
BEIJING INST FOR BRAIN DISORDERS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is a lack of systematic research on its role in ischemic stroke and its possible mechanisms

Method used

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  • Application of galanin to preparation of reagent for preventing cerebral ischemic stroke
  • Application of galanin to preparation of reagent for preventing cerebral ischemic stroke
  • Application of galanin to preparation of reagent for preventing cerebral ischemic stroke

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Embodiment Construction

[0031] The implementation of the present invention will be described in detail below in conjunction with the accompanying drawings and examples, so as to fully understand and implement the process of how to apply technical means to solve technical problems and achieve technical effects in the present invention. It should be noted that, as long as there is no conflict, each embodiment and each feature in each embodiment of the present invention can be combined with each other, and the formed technical solutions are all within the protection scope of the present invention.

[0032] The purpose of the present invention is to explore the role of galanin in ischemic stroke and its possible molecular mechanism by using the whole MCAO model of ischemic stroke in mice. This will further enrich people's understanding of cerebral ischemia / hypoxic injury and adaptation mechanisms, and provide experimental evidence for the clinical prevention and treatment of ischemic stroke.

[0033] The...

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Abstract

The invention discloses application of galanin to preparation of a reagent for preventing cerebral ischemic stroke. The application is characterized in that in the reagent, galanin (GAL) or a galanin receptor (GalR1) is used as the effective constituent, and the reagent is injected into a lateral ventricle of an ischemic cerebral hemisphere when a brain stroke occurs suddenly or during cerebral ischemia surgery, so that the reagent can penetrate through the blood-brain barrier to directly act on ischemic brain tissue. By the adoption of the technical scheme, GAL is single in constituent and definite in effect as a short peptide, can be artificially synthesized easily, and has the advantage of being low in production cost.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of galanin in preventing ischemic stroke. Background technique [0002] Ischemia / hypoxia is a pathophysiological state characterized by insufficient oxygen / glucose supply in the whole or part of the body, which leads to the occurrence of some related diseases, such as asphyxia, altitude sickness, stroke, myocardial infarction, and tumor cell metastasis. Among these diseases, stroke has the highest morbidity and mortality. So far, the treatment of ischemic stroke mainly stays in early thrombolysis and rehabilitation. Although major research breakthroughs have significantly improved the therapeutic effect of stroke, especially in extending the thrombolytic window, the results are not satisfactory. In order to improve the curative effect, people began to shift the research focus to the endogenous protective function of the cells themselves, such as the mechanism of isch...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P9/10
CPCA61K38/1709A61K9/0085A61K38/177
Inventor 徐志卿李筠
Owner BEIJING INST FOR BRAIN DISORDERS
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