A personalized 3D printed bone tissue engineering scaffold with mosaic structure

Abstract

The invention discloses an individualized 3D (three-dimensional) printed bone tissue engineering stent with a mosaic structure. The stent is characterized in that a shape and a structure of a large area of bone defect of a jaw are rebuilt through 3D modeling. The stent comprises two parts, wherein one part is an outer outline stent used for restoring the shape and the structure of a cranio-facial bone defect, and the other part is an inner tubular stent used for promoting formation of blood vessels. The bone tissue engineering stent with the maintained shape and structure on the outer part and promoted formation of blood vessels in the inner part is formed by inoculating factors for promoting ossification, such as mesenchymal stem cells (MSCs) and / or a loaded bone morphogenetic protein (BMP), onto the outer stent, and inoculating factors for promoting the formation of the blood vessels, such as endothelial cells (ECs) and / or a loaded vascular endothelial cell growth factor (VEGF), onto the inner stent, so that stem cell proliferation, ossification differentiation, and angiopoiesis of a tissue engineering compound are facilitated, and quality and speed of osteanagenesis are improved.

Description

technical field [0001] The invention relates to a personalized 3D printing bone tissue engineering bracket with mosaic structure, in particular to a manufacturing method and application of a bracket for repairing large-area craniomaxillofacial bone defects. Background technique [0002] Large bone defects in the cranio-maxillofacial region due to trauma and tumors directly affect the patient's facial appearance and oral functions such as mastication and speech, which not only seriously damages the patient's physical and mental health, but also brings a huge burden to the social economy. Traditional bone grafting methods include autologous bone grafting, allograft or xenograft bone grafting, and artificial bone substitute materials. Autologous bone grafting is the gold standard for repairing bone defects. Generally, the patient's own ilium is used. Although its immune response is low, it will cause new trauma and potential infection to the donor site, and it is difficult to s...

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a manufacturing method and application of a personalized 3D printed cranio-maxillofacial bone tissue engineering scaffold containing a mosaic structure, aiming at solving the problem of bone tissue engineering scaffolds made in the prior art. Most of them have simple structure, fixed and single pore diameter, and simple pore communication mode, which is not conducive to bone regeneration and bone tissue vascularization.

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