Method for removing acetyl and coupling, adsorbing and separating D-glucosamine hydrochloride

A technology of glucosamine hydrochloride and glucosamine, which is applied in amino sugar, chemical instruments and methods, sugar derivatives, etc., can solve the problems of high energy consumption, large environmental pollution, complicated processes, etc., and achieves high extraction yield, The effect of less environmental pollution and low consumption of auxiliary materials

Active Publication Date: 2017-06-13
王惠
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to solve the technical difficulties of deacetylation of N-acetyl-D-glucosamine and separation of D-glucosamine in view of the defects of large environmental pollution, complicated process and high energy consumption in the production of D-glucosamine by the current fermentation method, Provide a simple, low-pollution, high-yield, low-cost method for preparing D-glucosamine hydrochloride

Method used

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  • Method for removing acetyl and coupling, adsorbing and separating D-glucosamine hydrochloride

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1 The method of deacetylation coupling adsorption separation D-glucosamine hydrochloride

[0026] The specific steps of the method are as follows:

[0027] 1. Heat and inactivate 200L of fermentation broth containing 98g / L of N-acetyl-D-glucosamine, filter it with a ceramic membrane with a pore size of 5nm, and dialyze the dense phase of the membrane with pure water to obtain 80.5g / L of N-acetyl-D-glucosamine. Filtrate 240L;

[0028] 2. Pump 240L ceramic membrane filtrate into the + Type strong acidic cation exchange resin (D001 strong acidic cation exchange resin produced by Jiangsu Suqing Water Treatment Engineering Group Co., Ltd.) deacetylation adsorption separation device, the reaction time of materials in the device is 240 minutes, and the reaction temperature is 90 ° C. Wash the saturated resin with pure water, and analyze the D-glucosamine (H) adsorbed in the resin with 12% hydrochloric acid. + The molar ratio to N-acetyl-D-glucosamine is 1:0.9-10)...

Embodiment 2

[0032] Example 2 The method of deacetylation coupling adsorption separation of D-glucosamine hydrochloride

[0033] The specific steps of the method are as follows:

[0034] 1. Heat and inactivate 200L of fermentation broth containing 95g / L of N-acetyl-D-glucosamine, filter it with a ceramic membrane with a pore size of 50nm, dialyze the dense phase of the membrane with pure water, and obtain a filter with a content of 80g / L. Liquid outlet 235L;

[0035] 2. Add 235L of filtrate to the electrodialysis device, and obtain 320L of desalted solution with a content of 58g / L after desalination by electrodialysis;

[0036] 3. Pump 320L of desalted liquid into the 001×7H filled with Shanghai Huazhen Technology Co., Ltd. + Type strong acid cation exchange resin deacetylation adsorption separation device, the reaction time of materials in the device is 180 minutes, and the reaction temperature is 93 ℃. Wash the saturated resin with pure water, and analyze the D-glucosamine (H) adsorbe...

Embodiment 3

[0040] Example 3 The method of deacetylation coupling adsorption separation of D-glucosamine hydrochloride

[0041] The specific steps of the method are as follows:

[0042] 1. 200L of fermentation broth containing 90g / L of N-acetyl-D-glucosamine after heat inactivation was filtered through a ceramic membrane with a pore size of 50nm, and the dense phase of the membrane was dialyzed with pure water. After merging the filtrates, use an organic roll-type membrane with a molecular weight cut-off of 3000D to filter, and dialyze the dense phase with pure water to obtain 281 L of filtrate with a content of 62 g / L;

[0043] 2. Pass 281L of the filtrate through a decolorization column filled with granular activated carbon and a cation exchange column filled with 001×7 strong acidic cation exchange resin produced by Zibo Dongda Chemical Industry Co., Ltd. to obtain 335L of decolorized and desalted liquid with a content of 51g / L ;

[0044] 3. The 335L decolorization and desalination l...

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Abstract

The invention provides a method for removing acetyl and coupling, adsorbing and separating D-glucosamine hydrochloride. The method comprises the following steps: carrying out pretreatment on a solution containing N-acetyl-D-glucosamine, and enabling the solution to pass through an acetyl removal and adsorption and separation device filled with cation exchange resin; removing the acetyl of the N-acetyl-D-glucosamine under a certain condition, and adsorbing and separating the D-glucosamine hydrochloride. According to the method provided by the invention, an advanced process of removing the acetyl of the N-acetyl-D-glucosamine and adsorbing and separating D-glucosamine to replace a traditional process of removing the acetyl by hydrochloric acid hydrolysis and concentrating and crystallizing to separate the D-glucosamine hydrochloride. The D-glucosamine hydrochloride produced by the method has the advantages of good product quality, high extraction yield, low consumption of auxiliary materials, simplicity and convenience for operation and small environment pollution.

Description

technical field [0001] The invention relates to a preparation process of D-glucosamine hydrochloride, in particular to a method for deacetylation coupling adsorption separation of D-glucosamine hydrochloride. Background technique [0002] D-glucosamine is a compound in which one hydroxyl group of glucose is replaced by an amino group. Molecular formula C 6 h 13 o 5 N, commonly known as amino sugar, referred to as amino sugar, also known as glucosamine, widely exists in nature. [0003] The chemical structural formula is: [0004] [0005] The health care and treatment effect of D-glucosamine on bones and joints was recognized by the medical circles of the United States, Europe and Japan in the 1990s, and it was successively approved as a health care product and medicine for marketing. So far, most of the bone and joint health foods listed in the world have added D-glucosamine. [0006] At present, domestic manufacturers mainly use the hydrolysis method of shrimp ski...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/06C07H1/00C07H1/06
Inventor 王惠
Owner 王惠
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