Complete chemical synthesis for lasso polypeptide

Abstract

The invention relates to a complete chemical synthesis method for realizing lasso polypeptide and analogues thereof through the support of multiple anchor points. The support of multiple anchor points is preferably selected from a cryptand-ion liquid compound. The trend of a polypeptide chain is controlled through the limitation and guiding of the connecting point, so as to form a topological lasso structure. The synthesis method provided by the invention is easily automated; the marketing of the lasso polypeptide drugs becomes possible; the complete chemical synthesis of the lasso polypeptide and analogues thereof is firstly realized; the domestic and overseas blank of the chemical synthesis of the lasso polypeptide at present can be filled up; the method has significance in chemically synthesizing the polypeptide and researching and developing the polypeptide drug.

Description

[0001] Technical field: [0002] The invention relates to the technical field of biochemical synthesis, in particular to a synthesis method of lasso polypeptide and its analogues. This synthetic method uses multi-anchor compound support to realize the first chemical total synthesis of lasso polypeptide or lasso polypeptide analogues, which can be used to synthesize lasso cyclic peptides and their analogues that are difficult to synthesize by traditional chemical methods or biological methods, and has great impact on peptide chemistry. development is important. [0003] Background technique: [0004] Lasso peptides are a class of natural peptide molecules with a topological lasso configuration. Named for its lasso-like configuration, it usually contains an N-terminal peptide ring connected by an isopeptide bond, and a C-terminal peptide chain tail is extended from the peptide ring through a peptide bond connection; the peptide chain tail turns from itself through the peptide l...

AI Technical Summary

Problems solved by technology

This situation has resulted in poor controllability and unautomation of the synthesis of lasso polypeptides, which is not conducive to the screening and modification of drug research and development, and the cost of marketization and the difficulty of popularization have increased sharply

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