Method for constructing engineering arterial blood vessel in vivo by taking melt-spinning fiber as skeleton

Abstract

The invention provides a method for constructing engineering arterial blood vessel in vivo by taking melt-spinning fiber as a skeleton. The method comprises the following steps: firstly preparing a melt spinning and medical silica gel tube composite mandrel, and then preparing the in-vivo engineering arterial blood vessel taking melt-spinning fiber as a skeleton by taking subcutaneous part of an animal as a bioreactor; the specific steps are as follows: 1) preparing the melt spinning and medical silica gel tube composite mandrel; 2) preparing the in-vivo engineering arterial blood vessel taking melt-spinning fiber as a skeleton by taking subcutaneous part of an animal as a bioreactor; and 3) performing in-situ transplanting of the in-vivo engineering arterial blood vessel so as to replace lesion blood vessels. The method has the advantages that the in-vivo engineering arterial blood vessel has good biocompatibility, all the components are originated from autologous tissues, and therefore, the artificial blood vessel is non-toxic, free from immunogenicity, and incapable of causing inflammation; due to the existence of melt spinning fiber, the prepared in-vivo engineering blood vessel has good mechanical strength, tenacity and compliance, and is suitable for surgical sewing operation.

Description

technical field [0001] The invention relates to a preparation method of an artificial blood vessel, in particular to a method for constructing an engineered arterial blood vessel in vivo with melt-spun fibers as a skeleton. Background technique [0002] Cardiovascular disease and peripheral vascular disease are among the diseases with the highest morbidity and mortality worldwide. It is estimated that by 2030, there will be as many as 23.3 million deaths related to cardiovascular disease. When the blood vessels are less narrow, treatments include angioplasty and stenting. But for highly narrowed or even blocked blood vessels, vessel bypass surgery is necessary, which has reached about 400,000 cases per year in the United States alone. Autologous blood vessels, the gold standard for vascular grafts, such as the saphenous vein and internal mammary artery, are commonly used in arterial bypass surgery. However, the use of autologous blood vessels requires a second operation, ...

AI Technical Summary

Problems solved by technology

However, traditional biological tubes (made by implanting medical silicone tubes in the abdominal cavity or subcutaneously of animals) have thin walls, weak mechanical properties, and cannot support the tubular shape, which limits the application of biological tubes. Therefore, it is imminent to improve the mechanical properties of traditional biological tubes.

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