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A kind of bone repair scaffold and preparation method thereof

A technology of bone repair and bone glue, applied in the fields of processing and manufacturing, medical science, prosthesis, etc., can solve the problems of insufficient bone cell induction performance, inconsistent bone defect shape, tissue irritation, etc., and achieve good bone cell induction activity and good biological phase. Capacitance, the effect of huge specific surface area

Active Publication Date: 2020-01-14
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, synthetic artificial bone has a wide range of sources, but usually has the following disadvantages: (1) The biocompatibility is not superior. The materials used in the existing synthetic artificial bone are mainly mineral materials (such as calcium phosphate, hydroxyapatite) and biodegradable Polymers, etc., although artificial bone can gradually decompose with the growth of autologous bone tissue, there are still shortcomings such as the mismatch between the degradation rate of artificial bone and the growth of autologous bone, and the degradation products during the decomposition process stimulate the tissue; (2 ) bone cell induction performance is insufficient, because the bone repair material is non-autologous tissue, there will be a certain tissue reaction after implantation, which will affect the crawling growth of cells; and the research results show that various cytokines such as autologous Collagen, protein and other factors work together, pure mineral materials, synthetic materials or only adding a growth factor method cannot well simulate the osteogenic activity of autologous bone tissue and promote bone repair; (3) and clinical The shape of the actual bone defect in the wound is inconsistent, which makes it difficult for the bone filler to fit well with the autologous tissue. There is a large gap between the filler and the autologous bone during application, resulting in excessive collagen cells generated in the wound bone tissue and affecting the survival of the bone tissue.
[0004] Bone grafting can fill the bone cavity and accelerate the healing of bone defects. As the "gold standard" of bone filling technology, autologous bone grafting has been widely recognized by clinicians. For example, when the bone defect has a special shape, it is often necessary to cut and shape the removed bone, resulting in waste of removed bone

Method used

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  • A kind of bone repair scaffold and preparation method thereof
  • A kind of bone repair scaffold and preparation method thereof
  • A kind of bone repair scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Preparation of autologous bone meal and autologous bone glue

[0051] 1. Put the autogenous bone into a freeze-drying grinder and pulverize it fully to prepare superfine bone powder with a particle size of 30 μm;

[0052] 2. Put the bone meal into a mixed solution containing acetic acid, trypsin, NaCl and Tween 80, stir well, the concentration of acetic acid is 0.3 M, the concentration of trypsin is 50 mg / L, and the concentration of NaCl is 0.5 M. The concentration of Tween 80 is 20 ml / L;

[0053] 3. Put the above mixture into the container and keep stirring during the process;

[0054] 4. Take out the liquid in the container, put it into a freeze-drying box, and freeze-dry to prepare the freeze-dried powder of autologous bone glue;

[0055] 5. Take out the remaining bone meal in the container, and freeze-dry to obtain the autologous bone meal.

[0056] 2. Prepare the scaffold body conforming to the bone defect site by 3D printing

[0057] 1. Mix autologous bone ...

Embodiment 2

[0065] 1. Preparation of autologous bone meal and autologous bone glue

[0066] 1. Put the autogenous bone into a freeze-drying grinder and pulverize it fully to prepare superfine bone powder with a particle size of 5 μm;

[0067] 2. Put the bone meal into a mixed solution containing acetic acid, trypsin, NaCl and Tween 80, stir well, the concentration of acetic acid is 0.1M, the concentration of trypsin is 10mg / L, and the concentration of NaCl is 0.1M, spit out The concentration of Wen 80 is 1ml / L;

[0068] 3. Put the above mixture into the container and keep stirring during the process;

[0069] 4. Take out the liquid in the container, put it into a freeze-drying box, and freeze-dry to prepare the freeze-dried powder of autologous bone glue;

[0070] 5. Take out the remaining bone meal in the container, and freeze-dry to obtain the autologous bone meal.

[0071] 2. Prepare the scaffold body conforming to the bone defect site by 3D printing

[0072] In this embodiment, th...

Embodiment 3

[0077] 1. Preparation of autologous bone meal and autologous bone glue

[0078] 1. Put the autogenous bone into a freeze-drying grinder and pulverize it fully to prepare superfine bone powder with a particle size of 500 μm;

[0079] 2. Put the bone meal into a mixed solution containing acetic acid, trypsin, NaCl and Tween 80, stir well, the concentration of acetic acid is 1M, the concentration of trypsin is 200mg / L, the concentration of NaCl is 1M, Tween 80 The concentration is 50ml / L;

[0080] 3. Put the above mixture into the container and keep stirring during the process;

[0081] 4. Take out the liquid in the container, put it into a freeze-drying box, and freeze-dry to prepare the freeze-dried powder of autologous bone glue;

[0082] 5. Take out the remaining bone meal in the container, and freeze-dry to obtain the autologous bone meal.

[0083] 2. Prepare the scaffold body conforming to the bone defect site by 3D printing

[0084] In this embodiment, the preparation ...

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Abstract

The invention provides a bone restoration support and a preparation method thereof. The bone restoration support comprises a support main body prepared from autologous bone powder and autologous bone glue, a nano calcium phosphate coating deposited on the surface of the support main body, and the autologous bone glue covering the surface of the nano calcium phosphate coating and / or filled in pores of the support main body. The support main body has good biological compatibility and bone cell inductive activity, so that a bone defect portion is better restored, the bone restoration support has large specific surface area by virtue of the nano calcium phosphate coating, so that the adhesion, crawling and growth of cells are facilitated; and moreover, due to the existence of the autologous bone glue, at a preliminary period when the bone restoration support is implanted into a human body, a great number of active factors can be released, and osteoclast and osteoblast can be absorbed to induce the formation of new bones. In addition, by adopting a 3D (three dimensional) printing technology, the prepared bone restoration support is highly matched with the bone defect portion of a patient.

Description

technical field [0001] The present invention relates to the field of bone restorations, more specifically, to a bone restoration scaffold and a preparation method thereof. Background technique [0002] Bone defect is a common disease in orthopedic clinic. In clinical operations, bone repair materials are usually used to fill the defect to promote the regeneration of autologous bone tissue, thereby achieving the purpose of bone repair. [0003] Existing bone repair materials can be divided into synthetic artificial bone and autologous bone. Among them, synthetic artificial bone has a wide range of sources, but usually has the following disadvantages: (1) The biocompatibility is not superior. The materials used in the existing synthetic artificial bone are mainly mineral materials (such as calcium phosphate, hydroxyapatite) and biodegradable Polymers, etc., although artificial bone can gradually decompose with the growth of autologous bone tissue, there are still shortcoming...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/32A61L27/56B29C64/10B33Y70/00
CPCA61L27/32A61L27/3608A61L27/365A61L27/3683A61L27/3687A61L27/3691A61L27/56A61L2300/412A61L2430/02B33Y70/00
Inventor 王国帅袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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