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Compound probiotic preparation for dialysis patients to adjust body fluid acid-base balance and reduce blood potassium ion and preparation method thereof

A technology of compound probiotics and preparations, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, metabolic diseases, etc., can solve the problem of inability to achieve regulatory effects, fail to meet the rehabilitation needs of dialysis patients, and do not consider the regulation of probiotic metabolites function and other issues, to achieve the effect of solving constipation problems, accelerating emptying, and activating the immune system

Active Publication Date: 2020-04-03
北京伯恩世纪科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the application of probiotics with the ability to decompose urea toxins can achieve multiple effects at one stroke. However, the existing probiotic products do not consider the regulation of probiotic metabolites on the body fluids of patients, but only consider the role of probiotics themselves. Bacterial colonization is affected by many factors. Simply considering the role of probiotics often does not achieve a good regulatory effect and cannot meet the rehabilitation needs of dialysis patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The compound probiotic preparation described in this embodiment is made from the following raw materials (by weight): 18 parts of mixed bacteria liquid, 15 parts of fructooligosaccharide, 20 parts of glucose, 1 part of salt, 390 parts of demineralized water; The bacteria liquid is made by mixing Lactobacillus bulgaricus, Bifidobacterium, Acetobacter, Bacillus and Lactobacillus acidophilus, the ratio between them is 2:3:5:3:3, and the Lactobacillus bulgaricus , the live bacteria content of Bifidobacterium, Acetobacter, Bacillus and Lactobacillus acidophilus is 2 billion / ml.

[0022] The preparation method adopted in this embodiment is: sequentially add the mixed bacterial liquid, fructooligosaccharide, glucose, salt, and demineralized water in the fermenter; ferment at 28 degrees for 250 hours, then cool down to 19 degrees, Ferment for another 12 hours, release the bacterial liquid, and then pack the finished product.

[0023] Select 50 patients with the following sympt...

Embodiment 2

[0026]The compound probiotic preparation described in this embodiment is made from the following raw materials (by weight): 13 parts of mixed bacterial liquid, 6 parts of fructooligosaccharide, 22 parts of glucose, 2 parts of salt, 390 parts of demineralized water; The bacterial liquid is made by mixing Lactobacillus bulgaricus, Bifidobacterium, Acetobacter, Bacillus and Lactobacillus acidophilus, the ratio between them is 2:3:4:4:3, and the Lactobacillus bulgaricus , the live bacteria content of Bifidobacterium, Acetobacter, Bacillus and Lactobacillus acidophilus is 2.2 billion / ml.

[0027] The preparation method adopted in this embodiment is: sequentially add the mixed bacterial liquid described in claim 1, fructooligosaccharide, glucose, salt and demineralized water into the fermenter; ferment at 25 degrees for 240 hours, then cool down to 18 degrees , and then ferment for 10 hours, release the bacterial liquid, and then pack the finished product.

[0028] Select 50 patien...

Embodiment 3

[0031] The compound probiotic preparation described in this embodiment is made from the following raw materials (by weight): 15 parts of mixed bacteria liquid, 10 parts of fructooligosaccharide, 22 parts of glucose, 3 parts of salt, 390 parts of demineralized water; The bacteria solution is made by mixing Lactobacillus bulgaricus, Bifidobacterium, Acetobacter, Bacillus and Lactobacillus acidophilus, the ratio between them is 4:3:3:5:4, and the Lactobacillus bulgaricus , the live bacteria content of Bifidobacterium, Acetobacter, Bacillus and Lactobacillus acidophilus is 2.4 billion / ml.

[0032] The preparation method adopted in this embodiment is: sequentially add the mixed bacterial liquid described in claim 1, fructooligosaccharide, glucose, salt and demineralized water into the fermenter; ferment at 30 degrees for 270 hours, then cool down to 22 degrees , and then ferment for 14 hours, release the bacterial liquid, and then pack the finished product.

[0033] Select 50 pati...

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PUM

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Abstract

The invention discloses a complex probiotic preparation for regulating fluid acid-base equilibrium and reducing serum potassium ions of patients with hemodialysis. The complex probiotic preparation is prepared from the following raw materials in parts by weight: 12-18 parts of mixed bacteria liquor, 5-15 parts of fructo-oligosaccharide, 12-22 parts of glucose, 1-3 parts of edible salt and 390 parts of softened water; and the mixed bacteria liquor is prepared by mixing two or more than two out of lactobacillus bulgaricus, Bifidobacterium, Acetobacter aceti, bacillus and lactobacillus acidophilus. By adopting the prepared complex probiotic preparation, the fluid acid-base equilibrium can be regulated and serum potassium ions can be reduced through metabolite generated during fermentation; in addition, the probiotic can decompose harmful toxics such as urea nitrogen and creatinine in intestinal tract in vivo, dry and hard faeces can be rapidly softened by fermented product acetic acid and lactic acid so as to stimulate intestinal trace movement to solve the problem of constipation, the emptying of harmful toxics can be accelerated, and the immune system can be activated.

Description

technical field [0001] The invention relates to a compound probiotic preparation, in particular to a compound probiotic preparation for dialysis patients to regulate body fluid acid-base balance and reduce blood potassium ions and a preparation method thereof. Background technique [0002] Chronic renal failure refers to a clinical syndrome composed of a series of symptoms and metabolic disorders caused by various kidney diseases leading to progressive irreversible decline in kidney function until the loss of function. There are many primary diseases leading to chronic renal failure, mainly including chronic nephritis, hypertension and diabetes. With the advent of my country's aging society, the high incidence of hypertension, hyperglycemia and other diseases has led to a continuous increase in the incidence of chronic kidney disease. The incidence of chronic kidney disease in my country is as high as 11%, and it is increasing year by year; different from European and Ameri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/747A61P3/12A61K35/741A61K35/742A61K35/745
CPCA61K9/0095A61K35/741A61K35/742A61K35/745A61K35/747A61K2236/19A61K2300/00
Inventor 王楚璇曹军周雷
Owner 北京伯恩世纪科技发展有限公司
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