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A core-shell double-layer microsphere with polydioxanone as the core and its preparation method and application

A polydioxanone and microsphere technology, which is applied in the field of biomedicine, can solve the problems of single-layer microsphere burst release and low encapsulation rate, unable to control the slow release time, slow degradation time, etc., to achieve low cost, Good repeatability and slow degradation effect

Active Publication Date: 2018-10-02
重庆瑞凡德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the microspheres prepared by these materials either degrade very quickly, or degrade very slowly or cannot degrade
[0003] Therefore, there is an urgent need for a material and its preparation method that can solve the problems of low burst release and encapsulation rate of single-layer microspheres and the inability to control the sustained release time.

Method used

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  • A core-shell double-layer microsphere with polydioxanone as the core and its preparation method and application
  • A core-shell double-layer microsphere with polydioxanone as the core and its preparation method and application
  • A core-shell double-layer microsphere with polydioxanone as the core and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) According to the mass volume ratio (g / mL) of polydioxanone and hexafluoroisopropanol as 8:100, add polydioxanone to hexafluoroisopropanol to the polydioxanone Dioxanone is completely dissolved, and after adding chloroform and stirring, it is added dropwise in the polyvinyl alcohol aqueous solution to obtain a mixed solution. At this time, the volume ratio of hexafluoroisopropanol and chloroform in the mixed solution is 2.5:1. The mass ratio of polydioxanone and polyvinyl alcohol in the aqueous solution of polyvinyl alcohol is 1:1, and the mixed solution is homogeneously stirred at 6000 rpm until the emulsification is complete, and then water solidified with a volume twice the volume of the mixed solution is added. Microspheres, the temperature of the water is 2°C, and an emulsion containing polydioxanone microspheres is prepared;

[0035] (2) Distill the emulsion prepared in step (1) at 55° C. and 0.08 MPa for 30 minutes until the hexafluoroisopropanol and chlorofor...

Embodiment 2

[0041] (1) According to the mass volume ratio (g / mL) of polydioxanone and hexafluoroisopropanol as 1:100, add polydioxanone to hexafluoroisopropanol to the polydioxanone Dioxanone was completely dissolved, then added dichloromethane and stirred, then added dropwise to polyethylene glycol aqueous solution to obtain a mixed solution. At this time, the volume ratio of hexafluoroisopropanol and dichloromethane in the mixed solution was 1:1 , the mass ratio of polydioxanone and polyethylene glycol in aqueous solution of polyethylene glycol is 2:1, the mixed solution is homogeneously stirred at 4000rpm until the emulsification is complete, and the added volume is 3 times of the mixed solution water-cured microspheres, the temperature of the water is 5°C, and an emulsion containing polydioxanone microspheres is obtained;

[0042] (2) Distill the emulsion prepared in step (1) at 55° C. and 0.08 MPa for 50 minutes until the hexafluoroisopropanol and dichloromethane in the emulsion are ...

Embodiment 3

[0048] (1) According to the mass volume ratio (g / mL) of polydioxanone and hexafluoroisopropanol as 4:100, add polydioxanone to hexafluoroisopropanol to the polydioxanone Dioxanone is completely dissolved, and after adding dichloromethane and stirring, it is added dropwise in the polyvinyl alcohol aqueous solution to obtain a mixed solution. At this time, the volume ratio of hexafluoroisopropanol and dichloromethane in the mixed solution is 1:1. The mass ratio of polydioxanone and polyvinyl alcohol in the aqueous polyvinyl alcohol solution is 1:2, and the mixed solution is homogeneously stirred at 7000 rpm until the emulsification is complete, and then water solidified with a volume 4 times that of the mixed solution is added. Microspheres, the temperature of the water is 1°C, and an emulsion containing polydioxanone microspheres is prepared;

[0049] (2) Distill the emulsion prepared in step (1) at 55° C. and 0.06 MPa for 60 minutes until the hexafluoroisopropanol and dichloro...

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Abstract

The invention relates to core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method and application of the core-shell double-layer microspheres, belongs to the technical field of biological medicines, and provides core-shell double-layer microspheres employing poly(p-dioxanone) as cores and a preparation method of the core-shell double-layer microspheres. The method mainly comprises preparation of poly(p-dioxanone) microspheres and preparation of the double-layer microspheres with a core-shell structure by using the poly(p-dioxanone) microspheres. The method is simple in operation, good in repeatability and low in cost, and the preparation process is friendly to environment. The prepared microspheres are uniform and controllable are in particle size, safe, biodegradable, good in histocompatibility and slow in degradation; the degradation time can be regulated and controlled according to the type of a shell material and the adding ratios of core-shell materials. The microspheres can be widely applied to the fields of sustained release or controlled release drugs, and bioactive substance, cosmetic and soft tissue filling and repairing.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a core-shell double-layer microsphere with polydioxanone as the core, a preparation method and application thereof. Background technique [0002] Green B.X. and Wurster D.E. in the United States are the pioneers of microsphere technology. It has a history of 60 years since 1957. At first, microsphere technology was used to manufacture pressure-sensitive carbon copy paper, and then gradually expanded to food, medicine, and cosmetics. In the fields of photosensitive materials and textiles, with the continuous development of science and technology, people's requirements for pharmaceutical preparations are gradually increasing. Application, after the drug is microsphered and microencapsulated, it can prevent its oxidation and decomposition in the air, reduce the stimulation to human organs, and through slow release, it can reduce the drug dosage and prolong the drug ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/34A61L27/58A61L27/54A61L27/18A61K8/85A61K8/02A61Q19/00
CPCA61K8/025A61K8/85A61K9/5031A61K47/34A61K2800/10A61L27/18A61L27/54A61L27/58A61L2300/60A61L2300/802A61L2430/34A61Q19/00C08L67/04
Inventor 王秋玉李世荣
Owner 重庆瑞凡德生物科技有限公司
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