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Supramolecular assembly and preparation method and morphological control method thereof

A technology of supramolecular assembly and morphology, applied in the field of supramolecular, to avoid the effect of shielding effect

Active Publication Date: 2017-05-24
HUAIYIN TEACHERS COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the electrostatic interaction between molecules is an important non-covalent driving force for the construction of supramolecular self-assembled structures. The supramolecular assemblies prepared by electrostatic interactions are more likely to achieve morphology regulation and then controllable functions, and further expand the scope of supramolecular materials. However, there is no definite report on the method of modulating the morphology of supramolecular assemblies

Method used

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  • Supramolecular assembly and preparation method and morphological control method thereof
  • Supramolecular assembly and preparation method and morphological control method thereof
  • Supramolecular assembly and preparation method and morphological control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Synthesis of α-lysine-N-carboxy-anhydride (Lys(Z)-NCA)

[0038] (1) L-lysine (H-Lys(Z)-OH) and 20% excess triphosgene were reacted in tetrahydrofuran (THF) solvent at 50°C until clarified and then reacted for one hour to convert into L - Structure of lysine-N-carboxy-cyclic anhydride (Lys(Z)-NCA).

[0039] (2) The obtained L-lysine-N-carboxy-cyclic acid anhydride (Lys(Z)-NCA) monomer crude product was recrystallized and purified three times from THF and n-hexane in a glove box to obtain the final product for use.

Embodiment 2

[0040] Embodiment 2: synthetic polyethylene glycol-b-poly-L-lysine (PEG-b-PLL)

[0041] (1) First monomethoxypolyethylene glycol primary amine (mPEG-NH 2 ,M n =2000g mol -1 ) Vacuum-dried in a Schlenk bottle at 50°C in an oil bath for about 6 hours, and then cooled to room temperature;

[0042] (2) The L-lysine-N-carboxyl-cyclic anhydride (Lys(Z)-NCA) of Example 1 was dissolved in dry dimethylformamide (DMF) in a glove box, and then extracted with a syringe Then transfer to the Schlenk bottle and react under nitrogen protection and room temperature; after using FT-IR (Fourier Transform Infrared Spectrometer) spectrum to confirm that the reaction is complete, get a small amount of sample and prepare 5mg / mL for SEC / LLS (Size Exclusion Chromatography / laser scattering) test to determine polydispersity (PDI) and molecular weight (M n );

[0043] (3) After excessive ether precipitation, dissolve the product with a small amount of trifluoroacetic acid (TFA), add 5 times the equ...

Embodiment 3

[0045] Embodiment 3: prepare polyethylene glycol-b-poly-L-lysine (PEG 45 -b-PLL 109 ) solution

[0046] The PEG of embodiment 2 45 -b-PLL 109 Dissolved in water, configured into a solution with a molar concentration of 9.175 μM, and the measured molar concentration of the positive charge of the protonated amino group of the polylysine side chain in the solution is 1 mM.

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Abstract

The invention provides a supramolecular assembly based on a polyethylene glycol-b-poly-L-lysine and polyaliphatic ether dendrimer-b-DNA hybrid and a preparation method. Morphological control of the supramolecular assembly is realized by changing the charge proportion of polyethylene glycol-b-poly-L-lysine and polyaliphatic ether dendrimer-b-DNA hybrid in the supramolecular assembly, so that a new concept for researching and developing the property and assembling mechanism of the supramolecular assembly structure is provided, and further expansion of the application field of the supramolecular material becomes possible.

Description

technical field [0001] The application belongs to the field of supramolecular technology, and relates to a bio-organic hybrid structure formed by combining biomacromolecules and organic macromolecules, in particular to a supramolecular assembly and methods for its preparation and morphology regulation. Background technique [0002] In recent years, the bio-organic diblock hybrid structure formed by combining biomacromolecules and organic polymers has become a new research hotspot in the field of polymer materials. The respective properties of each block make them often exhibit various self-assembly behaviors in the solution. At the same time, the biomacromolecule block can also maintain the unique biological properties of biomacromolecules, making it suitable for use in bionanotechnology. It has broad application prospects in drug transportation and other aspects. In particular, DNA-synthetic polymer block copolymers formed by combining nucleic acid (DNA) with synthetic pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L77/04C08L87/00C08J3/00C08G69/40C08G83/00
CPCC08G69/40C08G83/004C08J3/00C08J2377/04C08J2387/00C08J2477/04C08J2487/00C08L77/04C08L87/00
Inventor 陈平王翔行岳真
Owner HUAIYIN TEACHERS COLLEGE
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