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Resurrection and consolidation method for TSH (Thyroid Stimulating Hormone) immunological competence ligand

A technology of immune activity and ligands, which is applied in the field of diagnosis and treatment of thyroid diseases, can solve the problems of secondary damage to the thyroid gland, difficulty in introduction, difficulty in finding biological immune active ligands, etc., and achieve the effect of improving qi and blood function

Inactive Publication Date: 2017-05-24
吴福勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, it is very difficult to find the above-mentioned biological immune active ligands. Finding a suitable ligand will generally cause other immune reactions, or other side effects, or difficult introduction, which needs to be completed through traumatic surgery, causing secondary damage to the thyroid gland , therefore, there is an urgent need for an active ligand and its introduction method without any side reactions

Method used

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  • Resurrection and consolidation method for TSH (Thyroid Stimulating Hormone) immunological competence ligand
  • Resurrection and consolidation method for TSH (Thyroid Stimulating Hormone) immunological competence ligand
  • Resurrection and consolidation method for TSH (Thyroid Stimulating Hormone) immunological competence ligand

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Experimental program
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Effect test

Embodiment 1

[0022] A TSH immunoactive ligand, comprising an active biological ligand and a conjugated compound; the active biological ligand is a hexamer of an IgG antibody Fab fragment or a tetramer of an F(ab')2 fragment, and the conjugated The combined compound is a compound of the following molecular formula:

[0023]

[0024] In the formula, R 2 represents the active biological ligand, X 1 means OH, R 1 means heptyl, X 2 represents a branched alkyl group having 12 carbon atoms, and m is 12.

[0025] The TSH immunoactive ligand also includes a Chinese medicine auxiliary composition, which is an oral medicine, and is composed of the following components by weight: 22 parts of Huang Du, 2 parts of psyllium, 55 parts of Tuckahoe, 6 parts of thistle extract, 6 parts of chickweed extract.

[0026] The extraction method of the artichoke extract is as follows: pulverize the artichoke, put it into a decoction bag and soak for 5 hours, move it into a decoction tank, decoct for 7 hours ...

Embodiment 2

[0030] A TSH immunoactive ligand, comprising an active biological ligand and a conjugated compound; the active biological ligand is a hexamer of an IgG antibody Fab fragment or a tetramer of an F(ab')2 fragment, and the conjugated The combined compound is a compound of the following molecular formula:

[0031]

[0032] In the formula, R 2 represents the active biological ligand, X 1 means SH, R 1 represents a branched chain alkyl group with 10 carbon atoms, X 2 represents a branched alkyl group having 20 carbon atoms, and m is 11.

[0033] The TSH immunoactive ligand also includes an auxiliary Chinese medicine composition, which is an oral medicine and consists of the following components by weight: 20 parts of Huang Du, 1 part of psyllium, 40 parts of Tuckahoe, 5 parts of thistle extract, 5 parts of chickweed extract.

[0034] The extraction method of the artichoke extract is as follows: pulverize the artichoke, put it into a decoction bag and soak for 2 hours, move i...

Embodiment 3

[0038] A TSH immunoactive ligand, comprising an active biological ligand and a conjugated compound; the active biological ligand is a hexamer of an IgG antibody Fab fragment or a tetramer of an F(ab')2 fragment, and the conjugated The combined compound is a compound of the following molecular formula:

[0039]

[0040] In the formula, R 2 represents the active biological ligand, X 1 means OH, R 1 represents a substituted alkyl, X 2 represents a branched alkyl group having 15 carbon atoms, and m is 19.

[0041] The TSH immunoactive ligand also includes an auxiliary Chinese medicine composition, which is an oral medicine and is composed of the following components by weight: 25 parts of Huang Du, 3 parts of psyllium, 80 parts of Tuckahoe, 8 parts of thistle extract, 8 parts of chickweed extract.

[0042] The extraction method of the artichoke extract is as follows: pulverize the artichoke, put it into a decoction bag and soak for 10 hours, move it into a decoction tank, ...

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Abstract

The invention discloses a resurrection and consolidation method for a TSH (Thyroid Stimulating Hormone) immunological competence ligand, belonging to the technical field of diagnosis and treatment of thyroid diseases. The TSH immunological competence ligand comprises an active biological ligand and a coupling compound, wherein the active biological ligand is a hexamer of a Fab fragment of an IgG (Intravenous Gamma Globulin) antibody or a tetramer of an F(ab')2 fragment. The active biological ligand disclosed by the invention competitively occupies a position of a TSH ligand of a thyroid disease patient in a body, so that an own ligand cannot be combined with a receptor, a physiological and biochemical reaction in a cell can be prevented, and further change of thyroid pathological tissues and the secretion of hyperthyroxycin are prevented; the secretion of follicular hyperthyroxycin is closed and blocked off, but the influence on normal beneficial hormones of a human body is avoided, and Qi and blood functions of the body are improved; by combining with traditional Chinese medicines, target acupuncture points are dredged to adjust a Yin-Yang balance mechanism of five internal organs, damaged thyroid follicle is repaired, and the balance and the stability of a human immune system is rebuilt.

Description

technical field [0001] The invention belongs to the technical field of diagnosis and treatment of thyroid diseases, and in particular relates to a TSH immune active ligand revitalization and solidification therapy. Background technique [0002] Biology emerged in the 1950s, and it has a very close relationship with medical engineering and biotechnology, and has become one of the main fields of competition in the world. As a key construction discipline of the national "211 Project" and "985 Revitalization Plan", biomedicine has received extensive attention from the society in recent years. Thyroid disease is a type of immune disease. The appearance of thyroid disease is that there are some abnormal immune substances against the thyroid gland in the body, such as abnormal ligands or antibodies. The existence of these substances will cause extreme effects on the thyroid gland. Large damage and destruction, through a substance that is more active than its own harmful antibody, ...

Claims

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Application Information

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IPC IPC(8): A61K47/59A61K39/395A61K36/8945A61P5/14
CPCA61K39/395A61K9/0019A61K9/0095A61K36/28A61K36/36A61K36/68A61K36/8945A61K36/896A61K36/90A61K2236/331A61K2300/00
Inventor 吴福勤
Owner 吴福勤
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