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Silk protein dental implant and preparation method thereof

A technology of silk protein and dental implants, applied in dental implants, dental preparations, dentistry, etc., can solve the problems of low human tissue compatibility and insufficient strength of dental implants, and achieve the effect of good human affinity and good compatibility

Active Publication Date: 2017-05-17
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, the purpose of the present invention is to provide a silk protein dental implant and its preparation method, which is used to solve the problems of insufficient dental implant strength and low compatibility with human tissue in the prior art

Method used

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  • Silk protein dental implant and preparation method thereof
  • Silk protein dental implant and preparation method thereof
  • Silk protein dental implant and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Such as figure 1 As shown, the present invention provides a kind of preparation method of silk protein-based capsule, and concrete preparation steps are:

[0043] First, step S1 is performed to prepare a silk protein solution.

[0044] The specific method for preparing the silk protein microneedle is:

[0045] 1) Heat the cocoons in sodium carbonate solution to degumming and form silk.

[0046] As an example, the concentration of the sodium carbonate solution is 0-100 g / L, and the mass ratio of the added cocoon to the sodium carbonate solution is 10:(1-100) g / L. The heating method is electric furnace heating or pressure cooker heating, the heating temperature is 50-120°C, and the heating time is 1s-1000h. By adjusting the process parameters of the degumming process, the molecular weight of silk protein can be controlled.

[0047] 2) Washing the silk in ultrapure water, repeating several times, and drying.

[0048] As an example, the washing in this step may be stirri...

Embodiment 2

[0068] What this embodiment prepares is silk protein dental implant.

[0069] Such as Figure 2 to Figure 7 As shown, 1 is the silk protein solution, 2 is the anhydrous silk protein, 3 is the hexafluoroisopropanol solution of the silk protein, 4 is the silk protein rod, 5 is the silk protein implant body, 6 is the tooth crown containing the ceramic Silk protein dental implants. The specific implementation steps include:

[0070] First execute step S1: figure 2 As indicated, silk protein solution 1 was prepared.

[0071] Specifically, in this embodiment, first, each portion of 10g silkworm cocoon is cut into pieces and placed in 4L of sodium carbonate solution with a concentration of 2g / L, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time is 0.5h .

[0072] Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 2...

Embodiment 3

[0085] The difference between this example and Example 1 is that in step S2 of this example, after the anhydrous silk protein is formed, zirconia ceramic powder is added to the anhydrous silk protein to form anhydrous silk protein and solid phase Reinforced Granular Mixed Powder.

[0086] Next, the mixed powder of anhydrous silk protein and solid phase reinforcement particles was dissolved in hexafluoroisopropanol. The finally formed fibroin rod is a composite material rod of fibroin and solid-phase reinforced particles.

[0087] In summary, the present invention provides a silk protein dental implant and a preparation method thereof, comprising the following steps: firstly preparing a silk protein solution; then converting the silk protein solution into anhydrous silk protein by a freeze-drying process; then converting the silk protein solution into anhydrous silk protein The anhydrous silk protein is dissolved in hexafluoroisopropanol to obtain a hexafluoroisopropanol solut...

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Abstract

The invention provides a silk protein dental implant and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a silk protein solution; secondly, transforming the silk protein solution into anhydrous silk protein according to a freeze-drying process; thirdly, dissolving an anhydrous silk protein solution into hexafluoroisopropanol to obtain a hexafluoroisopropanol solution of the silk protein; fourthly, injecting the hexafluoroisopropanol solution of the silk protein into the die, and obtaining a silk protein bar by a methanol treatment and air drying process; fifthly, cutting the silk protein bar into the dental implant, and also bonding a high-hardness dental crown on the surface of the dental implant. By controlling preparation parameters of the silk protein solution, and drying and curing parameters and the like as well as doping solid-phase reinforced particles, mechanical properties of silk protein can be controlled and the dental implant which is matched with mechanical parameters of human skeletons and dental occlusion and is well compatible with human biological tissues is obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a silk protein dental implant and a preparation method thereof. Background technique [0002] Dental implants, also known as the third set of teeth in humans, are a way to restore missing teeth based on the lower structure implanted in bone tissue to support and retain the upper tooth restoration. It consists of two parts, the lower supporting implant and the upper dental restoration. Artificial materials (such as metal, ceramics, etc.) are used to make implants (generally similar to tooth roots), which are surgically implanted into tissues (usually the upper and lower jaws) and obtain firm retention support of bone tissue, through special devices and methods Connection to support the upper dental restoration. Dental implants can achieve a restoration effect that is very similar to natural teeth in terms of function, structure, and aesthetics, and have become the pre...

Claims

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Application Information

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IPC IPC(8): A61C8/00A61K6/02
Inventor 不公告发明人
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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