Mouse obesity and alcohol synergistic interaction hepatopathy full-stomach nutrient solution

Abstract

The invention discloses a mouse obesity and alcohol synergistic interaction hepatopathy full-stomach nutrient solution which comprises the components in every 100 g of the mouse normal full-stomach nutrient liquid: 4.22 g of compound trace elements, 0.44 g of supplementary minerals, 2.5 g of fat-soluble vitamins, 20 UL of a complementary vitamin E, 1 ml of 0.1% folic acid and 0.2 g of a complementary vitamin, namely choline bitartrate. The mouse obesity and alcohol synergistic interaction hepatopathy full-stomach nutrient solution is characterized by further comprising the following components by weight: 19-20 g of protein powder, 22-23 g of fat, 49-50 g of carbohydrate and 0.21 g of cholesterol. The components are mixed, 15-18.4 ml of absolute ethyl alcohol and 160-165 ml of water are added to dissolve the components, and thus the mouse obesity and alcohol synergistic interaction hepatopathy full-stomach nutrient solution can be prepared. When the solution is injected into a mouse, a great number of lipid droplets can be generated inside liver cells within two weeks, and fatty degeneration and infection focus punctiform liver cell necrosis can be caused, resulting in formation of mouse fatty liver hepatitis, and thus pathological change that alcohol liver damage can be acutely exacerbated by obesity can be very well reproduced.

Description

technical field [0001] The invention relates to an animal nutrient solution, in particular to a whole stomach nutrient solution for mouse obesity and alcohol synergistic liver disease. Background technique [0002] With the improvement of people's living standards and sanitary conditions, overnutrition and alcohol intake are increasing rapidly. For liver disease, overnutrition and alcohol can be two independent causative factors, which cause non-alcoholic liver disease (NALD) and alcoholic liver disease (ALD), respectively. 20-30% of ALD will develop into hepatitis (SH), 10%-20% of NALD will develop into SH, and the incidence of liver cirrhosis in the latter is as high as 25% within 5-10 years. Epidemiological data show that obese drinkers are 2-3 times more likely to suffer from SH or liver cirrhosis than obese non-drinkers or normal weight drinkers. Therefore, domestic and foreign scholars have begun to pay attention to the synergistic aggravation of liver damage when th...

AI Technical Summary

Problems solved by technology

This kind of normal feed cannot be used as a whole stomach nutrient solution for mouse obesity and alcohol synergistic liver disease. Therefore, a kind of nutrition solution that not only ensures the normal nutritional needs of mice, but also can be closer to the obesity and drinking caused by modern people's living habits and diet culture Natural etiology, well reproduce the pathological changes of obese mice with acute aggravation of alcoholic liver damage Obese and alcohol synergistic liver disease Whole gastric nutrient solution is very necessary