Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof

A technology of chloroethyl and derivatives, which is applied in the preparation of carboxylic acid amides, amino compounds, and organic compounds. It can solve the problems of blocking and killing, reducing the defense function of the body, and achieves enhanced therapeutic index and reduced complications. The risk of disease and the effect of reducing toxic side effects

Inactive Publication Date: 2017-05-10
CHANGAN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Nitrogen mustards are commonly used anti-tumor drugs with particularly good anti-tumor activity. However, as traditional cytotoxic drugs, they still have the unique disadvantages of bioalkylating agents. At the same time, it also has an inhibitory effect on other normal cells that proliferate rapidly, for example, it also has the effect of blocking and killing some bone marrow cells, intestinal epithelial cells, and some hair cells, which will cause nausea, vomiting, Hair loss and other serious adverse reactions; in addition, nitrogen mustard drugs also have immunosuppressive effects, which will reduce the body's defense function, allowing bacteria and viruses to enter and cause various infections

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof
  • Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof
  • Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0038] The preparation method of the above-mentioned nitrogen mustard derivative N,N-bis(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine comprises the following steps:

[0039] Step 1, preparing N,N-bis(2-chloroethyl)-1,4-phenylenediamine;

[0040] Substep 1a, first prepare N,N-bis(2-hydroxyethyl)-4-nitroaniline according to the following steps: 4-chloronitrobenzene, diethanolamine, potassium carbonate and 1% CuSO 4 The solution is added to the reactor in turn, and stirred evenly, the CuSO 4For the solution, when the temperature is raised to 82°C, add toluene into the reactor, continue to heat up to 115-120°C, and stir at a constant temperature for 6-9 hours. Use thin-layer chromatography to track the reaction process. After the reaction is complete, distill to remove the toluene. Pour the remaining liquid after distillation into hot water at 50°C-70°C, stir, and after standing overnight, filter the water layer to obtain the crude product. Use absolute ethanol to recrysta...

Embodiment 1

[0045] 1.1 Synthesis of N,N-bis(2-hydroxyethyl)-4-nitroaniline

[0046]

[0047] Add 12.64g (0.080mol) of 4-chloronitrobenzene, 10.99g (0.104mol) of diethanolamine and 7.18g (0.052mol) of potassium carbonate to a 250mL three-necked flask, and finally add 1.2mL of CuSO with a mass concentration of 1%. 4 solution, mix well. Heat to raise the temperature. When the temperature reaches 82°C, add 5.0mL of toluene to the reaction liquid, continue to raise the temperature to control the reaction temperature to 117°C, use thin-layer chromatography to track the reaction progress, and stir at constant temperature for 6h. After the reaction is complete, toluene is removed by distillation, and the remaining liquid after distillation is poured into hot water at 50°C, stirred vigorously, left to stand overnight, and the water layer is removed by suction filtration to obtain a crude product, which is recrystallized with absolute ethanol to obtain a yellow needle 11.39 g of N,N-bis(2-hydro...

Embodiment 2

[0058] 1.1 Synthesis of N,N-bis(2-hydroxyethyl)-4-nitroaniline

[0059]

[0060] Add 4-chloronitrobenzene, diethanolamine and potassium carbonate at a molar ratio of 1:1.2:0.6 to a 250mL three-necked flask, and finally add CuSO with a mass concentration of 1%. 4 solution, and the mass concentration is 1% CuSO 4 The dosage ratio of the solution to 4-chloronitrobenzene is 0.5mL:3g, mix well; heat up the temperature, when the temperature reaches 82°C, add toluene to the reaction solution, and the dosage of toluene and 4-chloronitrobenzene The ratio was 1mL:2g; continue to increase the temperature to control the reaction temperature to 120°C, use thin-layer chromatography to track the reaction progress, and stir the reaction at constant temperature for 9h. After the reaction is complete, toluene is removed by distillation, and the mother liquor after distillation is poured into hot water at 60°C, stirred vigorously, left to stand overnight, and the water layer is removed by su...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Boiling pointaaaaaaaaaa
Densityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a structural formula of a nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine, and a preparation method thereof. The preparation method comprises the following steps: preparing N,N-di(2-chloroethyl)-1,4-phenylenediamine; putting the reaction raw materials comprising the N,N-di(2-chloroethyl)-1,4-phenylenediamine, dichloromethane and triethylamine into a reactor, cooling in ice-water bath, stirring, dropwise adding a mixed solution of hexadecanoyl chloride and dichloromethane into the reactor, removing the ice-water bath after addition, conducting reaction at room temperature for 12 to 14 hours, sequentially performing washing, drying and normal-pressure distillation on the reaction liquid after the reaction is conducted completely, and purifying the distilled filter cake to obtain the product. The arylamine nitrogen mustard derivative provided by the invention can effectively reduce the toxic and side effects of nitrogen mustard on the premise of enhancing the treatment index of the nitrogen mustard, and has sterilization and inflammation-diminishing curative effects to reduce the risk of complication caused by the fact that the immunity is reduced after a patient is subjected to chemical therapy.

Description

technical field [0001] The invention relates to the technical field of nitrogen mustard antitumor drugs, in particular to a nitrogen mustard derivative N,N-bis(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and its Preparation. Background technique [0002] Nitrogen mustards are commonly used anti-tumor drugs with particularly good anti-tumor activity. However, as traditional cytotoxic drugs, they still have the unique disadvantages of bioalkylating agents. At the same time, it also has an inhibitory effect on other fast-proliferating normal cells, such as some bone marrow cells, intestinal epithelial cells, and some hair cells, which can cause nausea, vomiting, Hair loss and other serious adverse reactions; in addition, nitrogen mustard drugs also have an immunosuppressive effect, which will reduce the body's defense function, allowing bacteria and viruses to enter and cause various infections. [0003] Nitrogen mustard anti-tumor drugs are composed of two parts in t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C233/43C07C231/02A61P35/00A61P37/06A61P31/00A61P29/00
CPCC07C209/36C07C231/02C07C233/43
Inventor 李春荣李发明邓红章郭靖茹王广华姬雨
Owner CHANGAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com