Anti-alcohol drink used for protecting liver and gastric mucosa

Abstract

The invention provides an anti-alcohol drink used for protecting liver and gastric mucosa, and a preparation method of the drink. The method comprises the steps of mixing semen hoveniae, radix salviae miltiorrhizae, radix puerariae, radix codcnopsitis pilosulas, pericarpium citri reticulatae, fructus lycii, flos puerariae, fructus crataegi, radix glycyrrhizae and fructus ligustri lucidi according to a weight ratio, and decocting a mixture twice by using water with the weight 8 times that of the mixture; and combining filter liquors and performing reduced pressure concentration to prepare fluid extract. By building models of acute liver injury and gastric mucosal lesion of mice, tissue forms of the liver and the gastric mucosa are checked, and indexes such as ALT, AST, ALB and the like in serum are measured; an immunohistochemical method is used for detecting expression situations of MnSOD, BCL-2 and Caspase-3 of the liver; a fluorescent PCR method is used for detecting gene expression levels of Nrf2 and SOD of liver tissues; gastric mucosal lesion indexes, inhibition rates and content of endothelin-1 and the like of the gastric mucosa of each group of mice are measured; the protection effect of the drink on the liver and gastric mucosa of a mouse is comprehensively researched; and experimental data proves that the drink can improve oxidation resistance of the liver and inhibit liver cell apoptosis, and has the effect of protecting gastric mucosal lesion.

Description

technical field [0001] The invention relates to a prescription of traditional Chinese medicine for hangover. More specifically, the present invention relates to a hangover drink for protecting the liver and gastric mucosa and a preparation method thereof. Background technique [0002] With the improvement of living standards, changes in dietary structure and increasing alcohol consumption, the incidence of alcoholic liver disease is increasing year by year worldwide. According to some data, the daily ethanol intake of adult men > 40g, and the intake of ethanol > 20-30g in women can lead to liver damage. Only 2-10% of ethanol entering the body is excreted through the lungs and kidneys, and most of the rest is catabolized in the liver. Ethanol metabolism causes oxidative stress in the body, oxidative stress can damage mitochondria, and ethanol can also directly lead to endoplasmic reticulum stress, which in turn leads to mitochondrial dysfunction, lipid accumulation, i...

AI Technical Summary

Problems solved by technology

[0003] Most of the existing anti-alcoholic medicines have the effect of sobering up and hangover, but they are only limited to delaying the drunken time of the drinker, relieving the symptoms such as headache and nausea of ​​the drunken, shortening the time of drunken sleep, and lack of anti-alcoholic drugs For the protective effect of the liver and gastric mucosa of drunken people; although there is a disclosed anti-alcoholic composition with liver-protecting effect, the pharmacology of anti-alcoholic drugs in the prevention or treatment of liver and gastric mucosal damage caused by drunkenness is lacking in the disclosed examples Science experiment example

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