Anti-alcohol drink used for protecting liver and gastric mucosa

A gastric mucosa and anti-alcoholic technology, applied in the field of anti-alcoholic drinks for protecting the liver and gastric mucosa and its preparation, can solve the problems of lack of pharmacological experimental examples of anti-alcoholic drugs, lack of liver and gastric mucosa protective effects of anti-alcoholic drugs, etc. , to achieve the effect of protecting gastric mucosa, promoting liver microcirculation, and protecting liver and gastric mucosa

Inactive Publication Date: 2017-05-03
庞晓军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing anti-alcoholic medicines have the effect of sobering up and hangover, but they are only limited to delaying the drunken time of the drinker, relieving the symptoms such as headache and nausea of ​​the drunken, shortening the time of drunken sleep, and lack of anti-alcoholic drugs For the protective ef...

Method used

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  • Anti-alcohol drink used for protecting liver and gastric mucosa
  • Anti-alcohol drink used for protecting liver and gastric mucosa
  • Anti-alcohol drink used for protecting liver and gastric mucosa

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0030] preparation of hangover drink

[0031] The anti-alcoholic drink for protecting the liver and gastric mucosa of the present invention is composed of the following raw materials in weight ratio: 20 parts by weight of Fructus Hoveniae Fructus, 10 parts by weight of Salvia Miltiorrhiza, 15 parts by weight of Radix Puerariae, 10 parts by weight of Codonopsis pilosula, 10 parts by weight of orange peel 10 parts by weight, 10 parts by weight of medlar, 10 parts by weight of kudzu flower, 5 parts by weight of hawthorn, 10 parts by weight of licorice, 10 parts by weight of privet fruit;

[0032] Wherein, the proportioning is calculated by dry weight with a moisture content of no more than 7%;

[0033] The preparation method of the Danshen nourishing heart teabag of the present invention comprises the following steps:

[0034]The Hovenia chinensis, Danshen, Pueraria lobata, Codonopsis pilosula, Tangerine peel, hawthorn, and licorice are pulverized through a coarse powder machin...

example 2

[0035] Experiment of the protective effect of Jiejiu drink on acute liver injury in mice

[0036] 1. Materials and Methods

[0037] 1.1 Experimental animals

[0038] 60 healthy Kunming mice: SPF grade, half male and half female, body weight 18-22g, provided by the Animal Center of Guangxi Medical University, license for use of experimental animals: SCXK Gui 2014-0002, and the temperature of the breeding environment is (23±2) ℃, and the humidity is 40% to 60%.

[0039] 1.2 Test drugs

[0040] The anti-alcoholic drink prepared by the method of the present invention

[0041] Bifendate dripping pills: Wanbangde Pharmaceutical Group Co., Ltd., batch number: A02141148, specification: 1.5mg / pill.

[0042] 1.3 Reagents and instruments

[0043] CCl 4 : Mulan Town Industrial Development Zone, Xindu District, Chengdu, batch number: 2014061301;

[0044] Coomassie brilliant blue detection kit: Nanjing Jiancheng Institute of Bioengineering, batch number: 20151008;

[0045] SOD kit ...

example 3

[0178] Experiment on the protective effect of Jiejiu Decoction on acute gastric mucosal injury in mice

[0179] 1. Materials and Methods

[0180] 1.1 Experimental animals

[0181] 60 healthy Kunming mice: SPF grade, half male and half female, body weight 18-22g, provided by the Animal Center of Guangxi Medical University, license for use of experimental animals: SCXK Gui 2014-0002, and the temperature of the breeding environment is (23±2) ℃, and the humidity is 40% to 60%.

[0182] 1.2 Test drugs

[0183] The anti-alcoholic drink prepared by the method of the present invention

[0184] Sucralfate chewable tablets: Jiangsu Pengyao Pharmaceutical Co., Ltd., batch number: 1501152, specification: 0.25g / tablet.

[0185] 1.3 Reagents and instruments

[0186] 95% ethanol: Industrial Development Zone, Mulan Town, Xindu District, Chengdu, batch number: 2014041801;

[0187] NO one-step kit: Nanjing Jiancheng Institute of Bioengineering, batch number: 20151104;

[0188] TNF-α kit...

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PUM

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Abstract

The invention provides an anti-alcohol drink used for protecting liver and gastric mucosa, and a preparation method of the drink. The method comprises the steps of mixing semen hoveniae, radix salviae miltiorrhizae, radix puerariae, radix codcnopsitis pilosulas, pericarpium citri reticulatae, fructus lycii, flos puerariae, fructus crataegi, radix glycyrrhizae and fructus ligustri lucidi according to a weight ratio, and decocting a mixture twice by using water with the weight 8 times that of the mixture; and combining filter liquors and performing reduced pressure concentration to prepare fluid extract. By building models of acute liver injury and gastric mucosal lesion of mice, tissue forms of the liver and the gastric mucosa are checked, and indexes such as ALT, AST, ALB and the like in serum are measured; an immunohistochemical method is used for detecting expression situations of MnSOD, BCL-2 and Caspase-3 of the liver; a fluorescent PCR method is used for detecting gene expression levels of Nrf2 and SOD of liver tissues; gastric mucosal lesion indexes, inhibition rates and content of endothelin-1 and the like of the gastric mucosa of each group of mice are measured; the protection effect of the drink on the liver and gastric mucosa of a mouse is comprehensively researched; and experimental data proves that the drink can improve oxidation resistance of the liver and inhibit liver cell apoptosis, and has the effect of protecting gastric mucosal lesion.

Description

technical field [0001] The invention relates to a prescription of traditional Chinese medicine for hangover. More specifically, the present invention relates to a hangover drink for protecting the liver and gastric mucosa and a preparation method thereof. Background technique [0002] With the improvement of living standards, changes in dietary structure and increasing alcohol consumption, the incidence of alcoholic liver disease is increasing year by year worldwide. According to some data, the daily ethanol intake of adult men > 40g, and the intake of ethanol > 20-30g in women can lead to liver damage. Only 2-10% of ethanol entering the body is excreted through the lungs and kidneys, and most of the rest is catabolized in the liver. Ethanol metabolism causes oxidative stress in the body, oxidative stress can damage mitochondria, and ethanol can also directly lead to endoplasmic reticulum stress, which in turn leads to mitochondrial dysfunction, lipid accumulation, i...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P1/04A61P39/02A61P1/16A23L33/105
CPCA61K36/72A23V2002/00A61K9/0095A61K36/344A61K36/48A61K36/484A61K36/488A61K36/537A61K36/638A61K36/734A61K36/752A61K36/815A61K2300/00A23V2200/32A23V2250/21
Inventor 庞晓军洪燕坪
Owner 庞晓军
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