Calcium salt bone cement and preparation method thereof

Abstract

The invention provides calcium salt bone cement and a preparation method thereof. The calcium salt bone cement comprises powder and a liquid; the powder comprises calcium sulfate hemihydrate and calcium phosphate; and the liquid is 0.05 to 5% of a sodium chloride solution or water. The calcium sulfate hemihydrates is prepared by crystal transformation, induced by calcium sulfate itself as a template, of calcium sulphate dehydrate, the hardening and difficult treatment problems of the calcium sulfate after the crystal transformation reaction can be improved, pressure is discharged rapidly, the temperature of the prepared calcium sulfate hemihydrate is kept not lower than the drying temperature, and the compressive strength of the calcium sulfate hemihydrate is enhanced. In the bone cement powder, a certain amount of calcium sulphate dehydrate powder is introduced into the prepared hemihydrate calcium sulfate powder, the percentage mass content of tricalcium phosphate in the bone cement is controlled for balancing, improvement and optimization of the injection and curing properties of the absorbable bone cement, the injection time of the bone cement is prolonged, the curing of the bone cement is accelerated, the compressive strength of the prepared bone cement is more than 15MPa, and the prepared bone cement can meet the needs of human cancellous bone repair, and is an excellent bone repair material.

Description

technical field [0001] The invention relates to an inorganic calcium salt degradable bone cement for bone tissue repair and a preparation method, which is mainly used in the fields of biomedical materials and the like. Background technique [0002] Artificial bone repair is an ideal method for the treatment of bone defects. As a traditional bone repair material, calcium sulfate has a good application prospect in bone repair because of its good biocompatibility and osteoconductivity. Since Dressman first used calcium sulfate to successfully heal bone defects, calcium sulfate bone repair materials have gradually developed. In 1996, Wright Company of the United States developed surgical grade calcium sulfate bone cement. And passed the US FDA and European certification; recently produced a new generation of injectable bone graft material MIIG bone cement, which not only has clinical curative effect, but also has more accurate and stable biological properties, and provides an ...

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Problems solved by technology

[0005] But the calcium sulfate hemihydrate that adopts conventional method to prepare, owing to change from pressure environment to normal pressure environment, because the discharge of pressure in the middle, causes the reduction of calcium sulfate temperature, after drying at certain temperature, grinding its crystallinity has defect, so its The strength cannot reach the ideal strength, and the combination of calcium phosphate and organic matter leads to a decrease in the mechanical properties of the related bone cement. The present invention adopts a specific air-permeable and water-impermeable distillation device to increase the contact area between calcium sulfate and the steam environment, so that The calcium sulfate crystallization reaction is completed as soon as possible, and in the pressure relief stage, the pressure is quickly discharged, and it is quickly transferred to the oven environment at the set drying temperature for drying to prepare high-strength calcium sulfate hemihydrate, and add calcium phosphate and select a certain liquid, to prepare high-strength absorbable bone cement, and to improve bone cement injection performance and water collapse resistance, and there is no report on the research on the relevant content of the present invention

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