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IP10 and interleukin combined cytokine for diagnosis of tuberculosis and kit thereof

A cytokine and IP-10 technology, applied in the field of disease diagnosis, can solve problems such as low accuracy of tuberculosis, sensitivity and specificity that cannot meet clinical requirements, and insufficient detection performance of IFN-γ, so as to improve diagnostic ability and high Effects of Sensitivity and Specificity

Inactive Publication Date: 2017-04-19
SHANGHAI RONGSHENG BIOLOGICAL PHARM CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as the only detection target of IFN-γ in the existing commercial Mycobacterium tuberculosis infection cell immunoassay reagents, its sensitivity and specificity cannot meet the clinical requirements. The reason may be the detection performance of IFN-γ on the one hand. Not high enough, some studies have shown that its accuracy in diagnosing tuberculosis is low
On the other hand, for a disease with high heterogeneity such as tuberculosis, the detection performance of a single target has certain limitations. Scholars at home and abroad are also looking for better biomarkers for the diagnosis of tuberculosis, exploring the combination of multiple cell Likelihood of diagnosis

Method used

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  • IP10 and interleukin combined cytokine for diagnosis of tuberculosis and kit thereof
  • IP10 and interleukin combined cytokine for diagnosis of tuberculosis and kit thereof
  • IP10 and interleukin combined cytokine for diagnosis of tuberculosis and kit thereof

Examples

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Embodiment 1

[0042] In this study, the plasma levels of five cytokines including IFN-γ, IL-6, IP-10, Eotaxin and RANTES were detected in the plasma of newly diagnosed tuberculosis patients and healthy persons.

[0043] IFN-γ, IL-6, Eotaxin, IP-10 and RANTES five cytokines in plasma levels (mean ± standard deviation) of 213 cases of newly diagnosed pulmonary tuberculosis patients and plasma of 29 healthy persons (see Table 1). Make a scatterplot of the two groups based on the data. The levels of IL-6, Eotaxin, IP-10 and RANTES in the plasma of tuberculosis patients were significantly higher than those of healthy people (Pfigure 1 B. figure 1 C. figure 1 D and figure 1 E), the difference of IFN-γ between the two groups was not statistically significant ( figure 1 A).

[0044] Table 1 The levels of cytokines in the plasma of patients with newly diagnosed pulmonary tuberculosis and healthy subjects (mean ± standard deviation)

[0045]

[0046] ROC curve of plasma cytokines in patients ...

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Abstract

The invention relates to application of cytokines IP-10 and IL-6 as a combined marker in preparation of a kit for diagnosis or monitoring of tuberculosis. The cytokines and a combination thereof provided by the invention can realize detection of cytokines in the plasma of newly diagnosed tuberculosis patients, can significantly improve the diagnosibility of pulmonary tuberculosis, and are conducive to prognosis of diseases and treatment situations thereof.

Description

technical field [0001] The invention relates to a disease diagnosis technique, in particular to a cytokine for diagnosing tuberculosis and a kit for detecting these cytokines. Background technique [0002] Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB). According to the statistics of WHO in 2014, there were 930,000 new cases of tuberculosis in my country, among the 22 countries with a high burden of tuberculosis. Ranked third after India and Indonesia, tuberculosis is the chronic infectious disease with the highest single-factor fatality rate in my country. Epidemiology shows that about 1 / 3 of the world's population is a carrier of Mycobacterium tuberculosis, and about 10% of the carriers can develop active tuberculosis [2]. With the prevalence of multidrug resistance tuberculosis cle bacillus (MDR-TB) and the increase of human immunodeficiency virus (Human immunodeficiency vinus, HIV) infection, the infection of Mycobacterium tu...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2333/522G01N2333/5412G01N2333/7155G01N2333/7158G01N2800/12
Inventor 冯晓燕张贺秋朱绍荣杨锡琴
Owner SHANGHAI RONGSHENG BIOLOGICAL PHARM CO LTD
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